A5062036823- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Rheumatoid Arthritis Research and Therapies
- Long-Term Effects of COVID-19
- Biosimilars and Bioanalytical Methods
- Vaccine Coverage and Hesitancy
- Inflammasome and immune disorders
- Systemic Lupus Erythematosus Research
- Dermatological and COVID-19 studies
- SARS-CoV-2 detection and testing
- Heparin-Induced Thrombocytopenia and Thrombosis
- Anesthesia and Sedative Agents
- Neonatal Respiratory Health Research
- Monoclonal and Polyclonal Antibodies Research
- Veterinary Orthopedics and Neurology
- Empathy and Medical Education
- Autoimmune and Inflammatory Disorders Research
- Injury Epidemiology and Prevention
- Anesthesia and Pain Management
- Musculoskeletal Disorders and Rehabilitation
- Pregnancy-related medical research
- Spine and Intervertebral Disc Pathology
- Reproductive Health and Contraception
- Hepatitis C virus research
- Preterm Birth and Chorioamnionitis
Reade
2020-2024
Amsterdam University Medical Centers
2019-2024
Center for Rheumatology
2024
University of Amsterdam
2020-2022
Ghent University Hospital
2017
Rijnstate Hospital
2011
Abstract Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 infections often cause only mild disease that may evoke relatively low Ab titers compared with patients admitted to hospitals. Generally, total bridging assays combine good sensitivity high specificity. Therefore, we developed sensitive for detection of SARS-CoV-2 Abs the receptor-binding domain (RBD) and nucleocapsid protein in addition conventional isotype-specific assays. kinetics was assessed PCR-confirmed, hospitalized...
There is a continuous debate about the risks of increased incidence COVID-19 in vulnerable patient groups, which includes patients with rheumatic diseases and especially those treated immunosuppressive antirheumatic drugs, including biologics. So far, results on outcomes these groups are reassuring: to date, neither presence disease nor use medication have shown associations higher infection rates or worse course COVID-19.1Favalli EG Ingegnoli F Cimaz R Caporali What true diseases?.Ann Rheum...
Background Research on the disease severity of COVID-19 in patients with rheumatic immune-mediated inflammatory diseases (IMIDs) has been inconclusive, and long-term prospective data development SARS-CoV-2 antibodies these are lacking. Methods Adult IMIDs from Amsterdam Rheumatology Immunology Center, were invited to participate. All asked recruit their own sex-matched age-matched control subject. Clinical collected via online questionnaires (at baseline, after 1–4 5–9 months follow-up)....
SUMMARY Despite the increased prevalence of hepatitis B and C in most migrant groups The Netherlands, a national screening policy for these infections is not available. In order to estimate largest group first-generation migrants (FGM) we conducted project Turkish community Arnhem. separate identified patients from target population with chronic hospital records (1990–2008). Educational meetings concerning were organized, all participants being offered blood test. Participants tested surface...
Tocilizumab in the treatment of rheumatoid arthritis (RA) is a potential candidate for concentration-guided tapering because standard dose tocilizumab results wide range serum concentrations, usually above presumed therapeutic window, and an exposure-response relationship has been described. However, no clinical trials have published to date on this subject. Therefore, objective study was assess feasibility intravenous (iv) with use pharmacokinetic model-based algorithm RA patients.
During the COVID-19 pandemic, we developed a digital research platform to longitudinally investigate COVID-19-related outcomes in patients with rheumatic diseases and healthy controls. We used home finger-prick testing order collect serum samples remotely increase overall efficiency of platform. The aim present study was evaluate success rate finger prick patients' perspective towards prick. Serum were collected up five times during follow-up, either via venepuncture at institute or from...
<h3>Background:</h3> The latest European and American recommendations support tapering of biological DMARDs (bDMARDs) in patients with persistent remission or low disease activity. Most clinicians use activity scores to monitor dose tapering. Considering the inter-individual variation serum concentration biologics, this trial-and-error approach is inevitably associated increased risk flare. Dose bDMARDs concentrations could lead too consequently ineffective flares. There compelling evidence...
Abstract SARS-CoV-2 infections often cause only mild disease that may evoke relatively low antibody titers compared to patients admitted hospitals. Generally, total bridging assays combine good sensitivity with high selectivity. Therefore, we developed sensitive for detection of antibodies the receptor-binding domain (RBD) and nucleocapsid protein (NP), in addition conventional isotype-specific assays. Antibody kinetics was assessed PCR-confirmed hospitalized COVID-19 (n=41) three...
Background: Patients with inflammatory rheumatic diseases such as rheumatoid arthritis (RA), psoriatic (PsA) and ankylosing spondylitis (AS) are at a higher risk for developing cardiovascular (CVD) than the general population. This increased is partly due to incidence of traditional (CV) factors, hypertension dyslipidemia, underlying systemic inflammation. During past two decades, burden inflammation has been reduced by more efficacious anti-inflammatory treatment, which somewhat attenuated...
Tocilizumab targets the interleukin-6 receptor, and dosing is complex owing to its nonlinear clearance related target binding. Therefore, tapering tocilizumab requires a different approach than that of tumor necrosis factor inhibitors (TNFi). This study aimed identify these differences enable personalized treatment rheumatoid arthritis (RA) beyond TNFi therapy.
<h3>Background</h3> Studies on long-term consequences of COVID-19, commonly referred to as long-COVID, in patients with inflammatory rheumatic diseases (iRD) are still scarce, and available data heterogeneous largely inconclusive. In addition, it is unknown whether correctly classifying iRD long-COVID cases complicated by increased background noise due the occurrence persistent symptoms that could be attributed both iRD. <h3>Objectives</h3> The primary objective was compare risk developing...
<h3>Background</h3> Previous studies have shown that using a finger prick as the primary method for blood withdrawal is an efficient way to collect samples remotely, and data on levels from are directly comparable obtained by venepuncture. During COVID-19 pandemic, we therefore complemented our large digital research platform with serum collection via home testing in order without need of visits hospital. This repeatedly enabled us rapidly answer new relevant clinical questions about...
<h3>Background and aims</h3> In ambulatory lower limb surgery, spinal anaesthesia with rapid onset a short duration of block is preferable. We hypothesized that the use 2-chloroprocaine would be associated faster full recovery from motor compared to prilocaine. difference 15 minutes was considered as clinically relevant. <h3>Methods</h3> 150 patients were randomly allocated receive either 40 mg or Primary outcome time complete blockade. Secondary parameters included regression sensory block,...
Background: The primary objective of this study was to compare the incidence and severity SARS-CoV-2 breakthrough infections between vaccinated patients with immune-mediated inflammatory diseases (IMIDs) using immunosuppressants, controls (IMID without immunosuppressants healthy controls). secondary explore determinants infections, including humoral immune responses after vaccination.Methods: In we pooled data collected in two large ongoing prospective multi-center cohort studies (Target...
Background Therapeutic Drug Monitoring (TDM) is a tool to determine the optimal dose of drug for individual patients using measurement blood concentrations and, optionally, anti-drug antibodies (ADA). In field rheumatology interest in applying TDM increasing. A recent study by Syversen et al., NOR-DRUM B trail, supports as treatment strategy. This showed that with proactive was more effective then without TDM. Applying creates personalized patients, therefore it relevant understand...
Background: Research on the disease severity of COVID-19 in patients with rheumatic immune-mediated inflammatory diseases (IMIDs) has been inconclusive, and long-term prospective data development SARS-CoV-2 antibodies these are lacking. We conducted an investigator-driven cohort study to compare COVID-19, over time between IMIDs healthy controls.Methods: Adult from Amsterdam Rheumatology & immunology Center, were invited participate. All asked recruit their own sex- age-matched control...