Abraham Rutgers
A5064790379- Vasculitis and related conditions
- Cell Adhesion Molecules Research
- Atherosclerosis and Cardiovascular Diseases
- Otitis Media and Relapsing Polychondritis
- SARS-CoV-2 and COVID-19 Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Systemic Lupus Erythematosus Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immunodeficiency and Autoimmune Disorders
- COVID-19 Clinical Research Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- T-cell and B-cell Immunology
- Sarcoidosis and Beryllium Toxicity Research
- Long-Term Effects of COVID-19
- Urticaria and Related Conditions
- Renal Diseases and Glomerulopathies
- Antibiotics Pharmacokinetics and Efficacy
- Cancer Immunotherapy and Biomarkers
- Peripheral Neuropathies and Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Monoclonal and Polyclonal Antibodies Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Antibiotic Resistance in Bacteria
- Autoimmune Bullous Skin Diseases
- Galectins and Cancer Biology
University Medical Center Groningen
2016-2025
University of Groningen
2016-2025
Misgav Ladach
2022
Universidad de Salamanca
2022
Dialyse Centrum Groningen
2011-2020
Center for Rheumatology
2013-2018
RELX Group (United States)
2018
Hôpital Raymond-Poincaré
2017
Université de Versailles Saint-Quentin-en-Yvelines
2017
Inserm
2017
Giant cell arteritis (GCA) is the most frequent form of vasculitis in persons older than 50 years. Cranial and systemic large vessels can be involved. [¹⁸F] fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed (CT) increasingly used to diagnose inflammation arteries GCA. Unfortunately, no consensus exists on preferred scoring method. In present study, we aim define optimal FDG PET/CT method for GCA diagnosis using temporal artery biopsy clinical as reference scans patients...
Several lines of evidence indicate that B cells may be involved in the immunopathology giant cell arteritis (GCA) and polymyalgia rheumatica (PMR). This study was undertaken to examine distribution defined subsets, including effector (Beff) regulatory (Breg) cells, patients with GCA PMR before after corticosteroid treatment.Circulating were analyzed 34 newly diagnosed, untreated or PMR, 44 followup samples from who received corticosteroids for 2 weeks 3 months. For comparison, 40 age-matched...
To compare multiple serum markers for their ability to detect active disease in patients with GCA and those PMR.Twenty-six related immune cells that may be involved PMR were determined by ELISA multiplex assay the of 24 newly diagnosed, untreated GCA/PMR patients, 14 corticosteroid (CS)-treated remission 13 healthy controls. Receiver operating characteristic analysis area under curve Spearman's correlation coefficients performed.Serum B-cell activating factor (BAFF), CXCL9 IL-6 increased...
Patients with inborn errors of immunity (IEI) are at increased risk severe coronavirus disease-2019 (COVID-19). Effective vaccination against COVID-19 is therefore great importance in this group, but little known about the immunogenicity vaccines these patients.We sought to study humoral and cellular immune responses after mRNA-1273 adult patients IEI.In a prospective, controlled, multicenter study, 505 IEI (common variable immunodeficiency [CVID], isolated or undefined antibody...
Abstract Objectives Adult-onset Still’s disease (AOSD) is a rare condition characterized by fevers, rash, and arthralgia/arthritis; most doctors treating AOSD in the Netherlands treat <5 patients per year. Currently, there no internationally accepted treatment guideline for AOSD. The objectives of this study were to conduct Delphi panel aimed at reaching consensus about diagnostic strategies with use outcomes as basis algorithm. Methods brought together 18 experts: rheumatologists,...
Abstract Objectives To compare clinical characteristics, imaging findings and treatment requirements of patients with immune checkpoint inhibitor-mediated polymyalgia rheumatica (ICI-PMR) primary PMR. Methods This single centre, retrospective cohort study compared ICI-PMR in cancer (n = 15) to PMR 37). A comparison was made between symptoms, laboratory markers, ultrasonography, 18F-FDG-PET/CT related Results Patients less frequently fulfilled the EULAR/ACR classification criteria for (66.7%)...
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a prototypic autoimmune disease, with subset of AAV patients manifesting anti-myeloperoxidase (MPO) IgG. Patients respond positively to B cell-targeting and complement-targeting therapies, but disease flares are not uncommon. Here, by comparing samples from healthy individuals MPO+ AVV patients, we show that cell autoreactivity against MPO in the circulation dominated CD27+IgM+ cells whereas MPO-specific IgG+...
Objective. Regulatory B cells (Bregs) constitute a subset of with immunomodulatory properties. Numerical and functional alterations in the Breg compartment have been associated autoimmunity. The aim this study was to assess frequency function Bregs patients ANCA-associated vasculitis (AAV). Methods. cell subsets were determined peripheral blood 48 AAV (12 active, 36 remission) 41 healthy controls (HCs) by flow cytometry. defined within CD19+ population as CD24hiCD38hi or CD24hiCD27+ cells....
Studies have suggested incremental short-term adverse events (AE) after repeated vaccination. In this report, we assessed occurrence and risk factors for AEs following SARS-CoV-2 vaccination in patients with various immune-mediated inflammatory diseases (IMIDs).
Abstract ANCA vasculitis encompasses several autoimmune conditions characterised by destruction of small vessels, inflammation the respiratory tract and glomerulonephritis. Most patients harbour autoantibodies to myeloperoxidase (MPO) or proteinase 3 (PR3). Clinical experimental data suggest that pathogenesis is driven ANCA-mediated activation neutrophils monocytes. We investigated a potential role for distinct monocyte subsets. found relative proportion intermediate monocytes increased in...
Abstract Introduction The present study aimed to explore a possible role for IL-21 producing Th-cells in the immunopathogenesis of granulomatosis with polyangiitis (GPA). Methods Peripheral blood from 42 GPA patients remission and 29 age-matched healthy controls (HCs) were stimulated vitro , frequencies determined by flow cytometry. Since Th17-cells produce low level IL-21, IL-17 was also included analysis. Given that is hallmark cytokine T follicular helper cells (T FH ), we next evaluated...
Post-operative delirium (POD) is associated with increased morbidity and mortality rates in older patients. Neuroinflammation, the activation of intrinsic immune system brain, seems to be one mechanisms behind development POD. The aim this study was explore association between perioperative inflammatory response POD a cohort oncological patients need for surgery.In prospective study, 65 years oncologic surgery were included. Inflammatory markers C-reactive protein (CRP), interleukin-1 beta...
Patients with inborn errors of immunity (IEI) are at increased risk severe coronavirus disease-2019 (COVID-19). Effective long-term protection against COVID-19 is therefore great importance in these patients, but little known about the decay immune response after primary vaccination. We studied responses 6 months two mRNA-1273 vaccines 473 IEI patients and subsequently to a third mRNA vaccine 50 common variable immunodeficiency (CVID).In prospective multicenter study, (including X-linked...
SARS-CoV-2-specific CD8
Granulomatosis with polyangiitis (GPA) is an autoimmune disorder characterized by recurrent relapses that can cause severe tissue damage and life-threatening organ dysfunction. Multiple immune cells cytokines/chemokines are involved in the different stages of disease. Immune profiling patients may be useful for tracking disease activity, however, reliable signatures GPA activity lacking. In this study, we examined circulating profiles during active remission states to identify potential...