A5016878392- Ocular Diseases and Behçet’s Syndrome
- Neuroendocrine Tumor Research Advances
- Immunodeficiency and Autoimmune Disorders
- Sarcoidosis and Beryllium Toxicity Research
- Retinal Diseases and Treatments
- Systemic Lupus Erythematosus Research
- Glaucoma and retinal disorders
- Ophthalmology and Eye Disorders
- Retinal and Optic Conditions
- Pituitary Gland Disorders and Treatments
- Neuroblastoma Research and Treatments
- Immune Cell Function and Interaction
- Infectious Diseases and Tuberculosis
- Lung Cancer Research Studies
- Systemic Sclerosis and Related Diseases
- IgG4-Related and Inflammatory Diseases
- Retinal Development and Disorders
- Myasthenia Gravis and Thymoma
- COVID-19 Clinical Research Studies
- Vasculitis and related conditions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Monoclonal and Polyclonal Antibodies Research
- Salivary Gland Disorders and Functions
- Chronic Lymphocytic Leukemia Research
- SARS-CoV-2 and COVID-19 Research
Erasmus MC
2016-2025
Chulalongkorn University
2019-2025
University of Indonesia
2025
Erasmus University Rotterdam
2012-2022
Azienda Ospedaliera Universitaria Pisana
2022
University of Pisa
2022
United States Nuclear Regulatory Commission
2022
Misgav Ladach
2022
Universidad de Salamanca
2022
Rotterdam University of Applied Sciences
1991-2021
Obesity is associated with local T-cell abnormalities in adipose tissue. Systemic obesity-related the peripheral blood compartment are not well defined. In this study, we investigated of morbidly obese and lean subjects. We determined all major subpopulations via six-color flow cytometry, including CD8+ CD4+ T cells, T-helper (Th) subpopulations, natural CD4+CD25+FoxP3+ T-regulatory (Treg) cells. Moreover, molecular analyses to assess thymic output, proliferation (T-cell receptor excision...
The soluble interleukin 2 receptor (sIL-2R) has been proposed as a marker of disease activity in patients with sarcoidosis. However, no studies have evaluated whether serum sIL-2R measurement is use establishing the diagnosis sarcoidosis who are suspected among other diseases.A cohort study was conducted, consisting new visited immunology outpatient clinic and whose levels were available before definitive established between February 2011 2016. All underwent standard diagnostic testing for...
Patients with inborn errors of immunity (IEI) are at increased risk severe coronavirus disease-2019 (COVID-19). Effective vaccination against COVID-19 is therefore great importance in this group, but little known about the immunogenicity vaccines these patients.We sought to study humoral and cellular immune responses after mRNA-1273 adult patients IEI.In a prospective, controlled, multicenter study, 505 IEI (common variable immunodeficiency [CVID], isolated or undefined antibody...
Increasing evidence suggests that neuropeptides play a role in the regulatory mechanisms between neuroendocrine and immune systems. A differential expression of five known somatostatin (SS) receptors (sst 1–5 ) has been demonstrated human cells tissues. However, little is concerning regulation sst peptide SS. Therefore, we investigated time-dependent , SS, cortistatin (CST), novel SS-like peptide, monocytes (MO), monocyte-derived macrophages (MP), dendritic (DC) basal lipopolysaccharide...
Tumours depend on sufficient blood supply for their growth. They are able to promote new vessel formation (neoangiogenesis) via angiogenic factors. Inhibition of this process results in tumour involution or necrosis. RGD (Arg-Gly-Asp) peptides described antagonise neoangiogenesis, e.g., by binding alpha(v)beta(3) receptors vessels. In order visualise neoangiogenesis tumours vitro and vivo, we introduced tested an analogue [c(Arg-Gly-Asp-D-Tyr-Lys)], coupled the chelator...
Platelet-derived growth factors (PDGF) are regulators of fibroblast activity that may be involved in the pathophysiology Graves' ophthalmopathy (GO). We unraveled expression and origin PDGF family members GO orbital tissue investigated effect isoforms on IL-6 hyaluronan production proliferation by fibroblasts. PDGF-A, PDGF-B, PDGF-C, PDGF-D, PDGF-Rα, PDGF-Rβ was determined real-time quantitative PCR PDGF-A PDGF-B protein Western blot tissues. Orbital tissues were immunohistochemically...
Introduction The etiology of Behçet's disease (BD) is unknown, but widely considered an excessive T-cell mediated inflammatory response in a genetically susceptible host. Recent genome-wide association studies (GWAS) have shown limited number novel loci-associations. rarity and unequal distribution the prevalence amongst different ethnic backgrounds hampered use GWAS cohorts mixed ethnicity sufficient sample size. However, statistical approaches now enabled admixed cohorts. Methods We ran on...
To test the hypothesis that ROSAH (retinal dystrophy, optic nerve oedema, splenomegaly, anhidrosis and headache) syndrome, caused by dominant mutation in
High-dose i.v. Ig (IVIg) is a prominent immunomodulatory therapy for various autoimmune and inflammatory diseases. Recent mice studies suggest that IVIg inhibits myeloid cell function by inducing cascade of IL-33-Th2 cytokine production causing upregulation the inhibitory FcγRIIb, as well modulating IFN-γ signaling. The purpose our study was to explore whether how these mechanisms are operational in IVIg-treated patients. We show patients results increases plasma levels IL-33, IL-4, IL-13...
Patients with hypogammaglobulinemia who do not fulfill all the classical diagnostic criteria for common variable immunodeficiency (reduction of two immunoglobulin isotypes and a reduced response to vaccination) constitute therapeutic dilemma, because information concerning clinical immunological characteristics these patients idiopathic primary is available. In 44 21 we determined phenotypes performed flow cytometric immunophenotyping assess pathophysiological B-cell patterns memory subset...
Mastocytosis is characterized by the accumulation of aberrant mast cells (MC). Patients suffering from mastocytosis suffer a wide range symptoms due to increased levels MC mediators. It would therefore be great benefit inhibit mediator release. However, date there are few drugs available that known effectively lower levels. The evidence for involvement janus kinase 2 (JAK2)-signal transducer and activation transcription 5 (STAT5) signalling pathway in slowly accumulating. Interference with...