A5062170314- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Psoriasis: Treatment and Pathogenesis
- Autoimmune and Inflammatory Disorders Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Systems, Economic Evaluations, Quality of Life
- Musculoskeletal pain and rehabilitation
- Workplace Health and Well-being
- Musculoskeletal Disorders and Rehabilitation
- Tryptophan and brain disorders
- Chronic Disease Management Strategies
- Spine and Intervertebral Disc Pathology
- Liver Diseases and Immunity
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer, Hypoxia, and Metabolism
- Multiple Sclerosis Research Studies
- Inflammasome and immune disorders
- Pregnancy and Medication Impact
- Mitochondrial Function and Pathology
- Adolescent and Pediatric Healthcare
- Patient Satisfaction in Healthcare
- COVID-19 and healthcare impacts
- Innovations in Medical Education
- COVID-19 and Mental Health
- Systemic Sclerosis and Related Diseases
Maastricht University Medical Centre
2018-2025
Maastricht University
2016-2025
University Medical Center
2014-2023
Center for Rheumatology
2022
University Hospital and Clinics
2016
Centre Hospitalier Chrétien
2016
To update the Assessment of SpondyloArthritis international Society (ASAS)-EULAR recommendations for management axial spondyloarthritis (axSpA).Following EULAR Standardised Operating Procedures, two systematic literature reviews were conducted on non-pharmacological and pharmacological treatment axSpA. In a task force meeting, evidence was presented, discussed, overarching principles updated, followed by voting.Five 15 with focus personalised medicine agreed: eight remained unchanged from...
Objectives. To investigate gender-attributable differences regarding clinical outcome [disease activity, physical function and quality of life (QoL)] radiographic damage in patients with AS over time. Methods. Data from the Outcome International Study were used. Disease activity was assessed by BASDAI, ASDAS CRP; BASFI; QoL Short Form-36, Ankylosing Spondylitis Quality Life (ASQoL) score European Of scale; modified Stoke Spine Score (mSASSS). Cross-sectional comparative analyses done at...
To compare the benefits of a tight-control/treat-to-target strategy (TC/T2T) in axial spondyloarthritis (axSpA) with those usual care (UC).Pragmatic, prospective, cluster-randomised, controlled, open, 1-year trial (NCT03043846). 18 centres were randomised (1:1). Patients met Axial Spondylo Arthritis International Society (ASAS) criteria for axSpA, had an Ankylosing Spondylitis Disease Activity Score (ASDAS) ≥2.1, received non-optimal treatment by non-steroidal anti-inflammatory drugs and...
To establish reference intervals (RIs) for work ability, at-work productivity loss and overall in the general working population to compare ability of patients with inflammatory rheumatic musculoskeletal disease (iRMD) this population. Cross-sectional analysis among iRMDs controls without having paid participating a Dutch cohort study. They reported on three outcomes: (0-10), (0%-100%). A generalised additive model location, shape scale parameters was used age-specific RIs percentile curves...
Aim As part of its strategic objectives for 2023, EULAR aims to improve the work participation people with rheumatic and musculoskeletal diseases (RMDs). One initiative focused on development overarching points consider (PtC) support RMDs in healthy sustainable paid participation. Methods EULAR’s standardised operating procedures were followed. A steering group identified six research areas Three systematic literature reviews, several non-systematic reviews two surveys conducted....
Patients with ankylosing spondylitis (AS) have a higher prevalence of depression compared to the general population. Comorbid in AS likely has multifactorial origin. While several disease-related and contextual factors been associated depressive symptoms AS, comprehensive model their interrelations is currently lacking. Such could help understand mechanisms leading to, or maintaining, AS. The objectives current study were determine which are underlying relationships.Data from cross-sectional...
Abstract Objective During the coronavirus disease 2019 (COVID-19) crisis, people with inflammatory rheumatic diseases (iRDs) might have been more vulnerable for adverse work outcomes (AWOs) and restrictions in ability performance. Our objectives were to compare AWOs during pandemic current between iRD patients controls, understand which are most these (3) explore role of characteristics on performance while working remotely. Methods Patients population controls a Dutch COVID-19 cohort study...
To explore (1) the prevalence of difficult-to-manage axial spondyloarthritis (D2M axSpA) in clinical practice according to Assessment SpondyloArthritis international Society (ASAS) definition, (2) specific components this definition contributing most its fulfilment, and (3) associated patient characteristics. This cross-sectional study used data from SpA-Net registry. Fulfilling ASAS required: treatment failure, insufficient disease control (any of: [A] high activity (AxSpA Disease Activity...
Objective To develop and test the usability acceptability of a disease-specific integrated electronic health (eHealth) system for spondyloarthritis (SpA) in Netherlands (‘SpA-Net’). Methods SpA-Net was developed four phases. First, content design were discussed with experts on SpA patients. Second, database, medical record (EMR) quality management developed. Third, multiple rounds testing performed. Fourth, eHealth implemented practice feasibility tested among patients through semistructured...
To investigate the occurrence of ankylosing spondylitis (AS)-related sick leave (SL) over 6 12 years and explore factors predicting first recurrent SL.Data from employed patients Outcome in Ankylosing Spondylitis International Study were used. At each visit, indicated SL (yes/no) previous inter-assessment period. Cox regressions predicted a episode SL. Generalised estimating equations (GEE) explored association between (time-lagged) predictors. whether predicts new SL, year was included as...
To update the knowledge on employment and role of mastery, a personal factor reflecting level control over life disease, among Dutch patients with ankylosing spondylitis (AS) compared to general population subjects.Data persons ≤65 years participating in cross-sectional multicentre study social participation AS were used. Being employed was main outcome. Standardised ratios (SERs) calculated using indirect standardisation after adjusting for age, gender education repeated stratification by...
Abstract Objectives To test the psychometric properties of United Kingdom’s Commissioning for Quality in Rheumatoid Arthritis Patient-Reported Experience Measure (CQRA-PREM) patients with spondyloarthritis (SpA) and rheumatoid arthritis (RA) to implement this questionnaire daily practice Netherlands. Methods After a forward-backward translation procedure into Dutch, CQRA-PREM was tested two quality registries practice. Face validity assessed focus group interviews. Feasibility evaluated...
Abstract Background Patients with ankylosing spondylitis (AS) are at increased risk of depression. This has been hypothesized to be solely secondary due AS-related symptoms, or additionally a common inflammatory pathway. From clinical perspective, it is important know whether treatment tumor necrosis factor alpha inhibitors reduces depressive while from pathophysiological point view, would insightful understand such an effect direct result reduced inflammation, the both. The objective this...
To evaluate the extent to which internationally agreed treat-to-target recommendations were applied in clinical practice patients with axial spondyloarthritis.
To investigate which factors are associated with treatment intensification (TI) in axial SpA (axSpA) patients high disease activity (HDA).
To describe the evolution of OMERACT Fellows Program (OM FP) and to evaluate innovative changes implemented in 2023 program.