Umesh D. Parashar

ORCID: 0000-0002-9684-9425
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About
Contact & Profiles
Research Areas
  • Viral gastroenteritis research and epidemiology
  • Hepatitis Viruses Studies and Epidemiology
  • Viral Infections and Immunology Research
  • Animal Virus Infections Studies
  • Congenital Anomalies and Fetal Surgery
  • Respiratory viral infections research
  • Gastrointestinal disorders and treatments
  • Vaccine Coverage and Hesitancy
  • Child Nutrition and Water Access
  • Virus-based gene therapy research
  • Advanced Thermodynamic Systems and Engines
  • Animal Disease Management and Epidemiology
  • Clostridium difficile and Clostridium perfringens research
  • SARS-CoV-2 and COVID-19 Research
  • Virology and Viral Diseases
  • Infection Control and Ventilation
  • COVID-19 epidemiological studies
  • Viral Infections and Vectors
  • Influenza Virus Research Studies
  • Food Security and Health in Diverse Populations
  • Data-Driven Disease Surveillance
  • Infant Nutrition and Health
  • Pneumonia and Respiratory Infections
  • Salmonella and Campylobacter epidemiology
  • Biomedical and Engineering Education

National Center for Immunization and Respiratory Diseases
2016-2025

Centers for Disease Control and Prevention
2016-2025

University of California, Irvine
2013-2024

National Center for Emerging and Zoonotic Infectious Diseases
2023-2024

Government of the United States of America
2024

Christian Medical College & Hospital
2024

Global Viral
2007-2022

The Centers
2010-2022

CDC Foundation
2010-2021

Hyattsville Community Development Corporation
2021

Studies published between 1986 and 1999 indicated that rotavirus causes approximately 22% (range 17%-28%) of childhood diarrhea hospitalizations. From 2000 to 2004, this proportion increased 39% 29%-45%). Application the recent World Health Organization estimates diarrhea-related deaths gave an estimated 611,000 454,000-705,000) rotavirus-related deaths.

10.3201/eid1202.050006 article EN cc-by Emerging infectious diseases 2006-02-01

Background. Rotavirus vaccine is recommended for routine use in all countries globally. To facilitate decision making on rotavirus adoption by countries, help donors prioritize investments health interventions, and monitor impact, we estimated mortality children <5 years of age from 2000 to 2013. Methods. We searched PubMed using the keyword "rotavirus" identify studies that met each following criteria: data collection midpoint year 1998 or later, study period a 12-month increment, detection...

10.1093/cid/civ1013 article EN public-domain Clinical Infectious Diseases 2016-04-08

<h3>Importance</h3> Rotavirus infection is the global leading cause of diarrhea-associated morbidity and mortality among children younger than 5 years. <h3>Objectives</h3> To examine extent rotavirus years by country number deaths averted because vaccine. <h3>Design, Setting, Participants</h3> This report builds on findings from Global Burden Disease Study 2016, a cross-sectional study that measured diarrheal diseases their etiologic agents. Models were used to estimate burden in data-sparse...

10.1001/jamapediatrics.2018.1960 article EN cc-by JAMA Pediatrics 2018-08-13

In February 2006, a live, oral, human-bovine reassortant rotavirus vaccine (RotaTeq) was licensed for use among U.S. infants. The Advisory Committee on Immunization Practices recommends routine vaccination of infants with 3 doses this administered orally at ages 2, 4, and 6 months. first dose should be between 6-12 weeks. Subsequent 4-10 week intervals, all by age 32 Rotavirus can co-administered other childhood vaccines. is contraindicated serious allergic reaction to any component or...

10.1037/e531952006-001 article EN PsycEXTRA Dataset 2006-01-01

Between July 1997 and June 2000, fecal specimens from 284 outbreaks of nonbacterial gastroenteritis were submitted to the Centers for Disease Control Prevention testing "Norwalk-like viruses" (NLVs). Specimens examined by reverse-transcription polymerase chain reaction direct electron microscopy presence NLVs. Adequate descriptive data available 233 outbreaks, and, these, 217 (93%) positive Restaurants events with catered food most common settings, contaminated was mode transmission....

10.1086/341085 article EN The Journal of Infectious Diseases 2002-07-01

Cases of rotavirus-associated acute gastroenteritis have declined since the introduction rotavirus vaccines, but burden norovirus-associated in children remains to be assessed.We conducted active surveillance for laboratory-confirmed cases norovirus among younger than 5 years age with hospitals, emergency departments, and outpatient clinical settings. The resided one three U.S. counties during 2009 2010. Fecal specimens were tested rotavirus. We calculated population-based rates reviewed...

10.1056/nejmsa1206589 article EN New England Journal of Medicine 2013-03-20

We retrospectively investigated two outbreaks of encephalitis in Meherpur and Naogaon, Bangladesh, which occurred 2001 2003. collected serum samples from persons who were ill, their household contacts, randomly selected residents, hospital workers, various animals. Cases classified as laboratory confirmed or probable. identified 13 cases (4 confirmed, 9 probable) Meherpur; 7 households. Patients more likely than nonpatients to have close contact with other patients a sick cow. In we 12 8...

10.3201/eid1012.040701 article EN cc-by Emerging infectious diseases 2004-12-01

Although recognized as the leading cause of epidemic acute gastroenteritis across all age groups, norovirus has remained poorly characterized with respect to its endemic disease incidence. Use different methods, including attributable proportion extrapolation, population-based surveillance, and indirect modeling, in several recent studies considerably improved incidence estimates for United States. Norovirus causes an average 570-800 deaths, 56,000-71,000 hospitalizations, 400,000 emergency...

10.3201/eid1908.130465 article EN cc-by Emerging infectious diseases 2013-07-10

From April through June 1997, 29 previously healthy children aged <6 years (median, 1.5 years) in Sarawak, Malaysia, died of rapidly progressive cardiorespiratory failure during an outbreak hand, foot, and mouth disease caused primarily by enterovirus 71 (EV71). The case were hospitalized after a short illness (median duration, 2 days) that usually included fever (in 100% children), oral ulcers (66%), extremity rashes (62%). progressed to include seizures (28%), flaccid limb weakness (17%),...

10.1086/314032 article EN Clinical Infectious Diseases 2000-09-01

The widespread use of a second dose mumps vaccine among U.S. schoolchildren beginning in 1990 was followed by historically low reports cases. A 2010 elimination goal established, but 2006 the largest outbreak two decades occurred United States.We examined national data on cases reported during 2006, detailed case from most highly affected states, and vaccination-coverage three nationwide surveys.A total 6584 were with 76% occurring between March May. There 85 hospitalizations, no deaths...

10.1056/nejmoa0706589 article EN New England Journal of Medicine 2008-04-09

Because postlicensure surveillance determined that a previous rotavirus vaccine, RotaShield, caused intussusception in 1 of every 10,000 recipients, we assessed the association new monovalent vaccine (RV1) with after routine immunization infants Mexico and Brazil.We used case-series case-control methods to assess between RV1 intussusception. Infants were identified through active at 69 hospitals (16 53 Brazil), age-matched from same neighborhood enrolled as controls. Vaccination dates...

10.1056/nejmoa1012952 article EN New England Journal of Medicine 2011-06-15

A phased introduction of a monovalent rotavirus vaccine occurred in Mexico from February 2006 through May 2007. We assessed the effect vaccination on deaths diarrhea Mexican children 2008 and 2009.We obtained data diarrhea, regardless cause, January 2003 2009 under 5 years age. compared diarrhea-related mortality during seasons with at baseline (2003-2006), before vaccine. Vaccine coverage was estimated administrative data.By December 2007, an 74% who were 11 months age or younger had...

10.1056/nejmoa0905211 article EN New England Journal of Medicine 2010-01-27

Background. Globally, gastroenteritis is recognized as an important contributor to mortality among children, but population-based data on deaths adults and the contributions of specific pathogens are limited. We aimed describe trends in across all ages United States specifically estimate Clostridium difficile norovirus.

10.1093/cid/cis386 article EN Clinical Infectious Diseases 2012-04-04
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