A5012371664- Clostridium difficile and Clostridium perfringens research
- Nosocomial Infections in ICU
- Microscopic Colitis
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Streptococcal Infections and Treatments
- COVID-19 Clinical Research Studies
- Infection Control and Ventilation
- Urinary Tract Infections Management
- SARS-CoV-2 detection and testing
- Healthcare cost, quality, practices
- COVID-19 epidemiological studies
- Infection Control in Healthcare
- Gut microbiota and health
- Antibiotics Pharmacokinetics and Efficacy
- Helicobacter pylori-related gastroenterology studies
- Patient Satisfaction in Healthcare
- COVID-19 and healthcare impacts
- Pneumonia and Respiratory Infections
- Mycobacterium research and diagnosis
- COVID-19 and Mental Health
Centers for Disease Control and Prevention
2016-2025
CDC Foundation
2014-2025
National Center for Emerging and Zoonotic Infectious Diseases
2015-2024
Centers for Disease Control and Prevention
2009-2024
Great North Children's Hospital
2023
Cleveland Clinic
2021
Saint Luke's Health System
2021
Regional Health
2021
Adventist HealthCare Rehabilitation
2010-2020
University Hospital Waterford
2020
Since publication of the Society for Healthcare Epidemiology America position paper on Clostridium difficile infection in 1995, significant changes have occurred epidemiology and treatment this infection. C. remains most important cause healthcare-associated diarrhea is increasingly as a community pathogen. A more virulent strain has been identified responsible more-severe cases disease worldwide. Data reporting decreased effectiveness metronidazole severe published. Despite increasing...
The magnitude and scope of Clostridium difficile infection in the United States continue to evolve.
A panel of experts was convened by the Infectious Diseases Society America (IDSA) and for Healthcare Epidemiology (SHEA) to update 2010 clinical practice guideline on Clostridium difficile infection (CDI) in adults. The update, which has incorporated recommendations children (following adult epidemiology, diagnosis, treatment), includes significant changes management this reflects evolving controversy over best methods diagnosis. remains most important cause healthcare-associated diarrhea...
Recent reports suggest that the rate and severity of Clostridium difficile-associated disease in United States are increasing increase may be associated with emergence a new strain C. difficile increased virulence, resistance, or both.A total 187 isolates were collected from eight health care facilities six states (Georgia, Illinois, Maine, New Jersey, Oregon, Pennsylvania) which outbreaks had occurred between 2000 2003. The characterized by restriction-endonuclease analysis (REA),...
Abstract A panel of experts was convened by the Infectious Diseases Society America (IDSA) and for Healthcare Epidemiology (SHEA) to update 2010 clinical practice guideline on Clostridium difficile infection (CDI) in adults. The update, which has incorporated recommendations children (following adult epidemiology, diagnosis, treatment), includes significant changes management this reflects evolving controversy over best methods diagnosis. remains most important cause healthcare-associated...
US hospital discharges for which Clostridium difficile-associated disease (CDAD) was listed as any diagnosis doubled from 82,000 (95% confidence interval [CI] 71,000-94,000) or 31/100,000 population in 1996 to 178,000 CI 151,000-205,000) 61/100,000 2003; this increase significant between 2000 and 2003 (slope of linear trend 9.48; 95% 6.16-12.80, p = 0.01). The overall rate during period severalfold higher persons >65 years age (228/100,000) than the group with next highest rate, 45-64...
Efforts to prevent Clostridioides difficile infection continue expand across the health care spectrum in United States. Whether these efforts are reducing national burden of C. is unclear.
Staphylococcus aureus is one of the most common pathogens in health care facilities and community, can cause invasive infections, sepsis, death. Despite progress preventing methicillin-resistant S. (MRSA) infections settings, assessment problem both community settings needed. Further, epidemiology methicillin-susceptible (MSSA) not well described at national level.Data from Emerging Infections Program (EIP) MRSA population surveillance (2005-2016) Premier Cerner Electronic Health Record...
The proportion of Staphylococcus aureus isolates that were methicillin resistant (MRSA) increased from 35.9% in 1992 to 64.4% 2003 for hospitals the National Nosocomial Infections Surveillance system. During same period, there was a decrease resistance rates several non—β-lactam drugs among MRSA isolates.
Background. The epidemiology of Clostridium difficile -associated disease (CDAD) is changing, with evidence increased incidence and severity. However, the understanding magnitude reasons for this change currently hampered by lack standardized surveillance methods. Objective Methods. An ad hoc C. working group was formed to develop interim definitions recommendations based on existing literature expert opinion that can help improve CDAD prevention efforts. Definitions Recommendations. A case...
Abstract US hospital discharges for which Clostridium difficile–associated disease (CDAD) was listed as any diagnosis doubled from 82,000 (95% confidence interval [CI] 71,000–94,000) or 31/100,000 population in 1996 to 178,000 CI 151,000–205,000) 61/100,000 2003; this increase significant between 2000 and 2003 (slope of linear trend 9.48; 95% 6.16–12.80, p = 0.01). The overall rate during period severalfold higher persons >65 years age (228/100,000) than the group with next highest rate,...
Background. This report compares the clinical characteristics, epidemiologic investigations, infection-control evaluations, and microbiologic findings of all 7 cases vancomycin-resistant Staphylococcus aureus (VRSA) infection in United States during period 2002–2006.
Multidrug-resistant (MDR) bacteria that are commonly associated with health care cause a substantial burden. Updated national estimates for this group of pathogens needed to inform public action.
Clostridium difficile infection (CDI) has been increasingly reported among healthy individuals in the community. Recent data suggest that community-associated CDI represents one-third of all C cases. The epidemiology and potential sources community are not fully understood.To determine epidemiological clinical characteristics to explore acquisition community.Active population-based laboratory-based surveillance 8 US states.Medical records were reviewed interviews performed assess outpatient,...
Abstract During the 2003–04 influenza season, 17 cases of Staphylococcus aureus community-acquired pneumonia (CAP) were reported from 9 states; 15 (88%) associated with methicillin-resistant S. (MRSA). The median age patients was 21 years; 5 (29%) had underlying diseases, and 4 (24%) risk factors for MRSA. Twelve (71%) laboratory evidence virus infection. All but 1 patient, who died on arrival, hospitalized. Death occurred in (4 MRSA). isolates available 13 (76%) (11 Toxin genes detected all...
ABSTRACT Using 42 isolates contributed by laboratories in Canada, The Netherlands, the United Kingdom, and States, we compared results of analyses done with seven Clostridium difficile typing techniques: multilocus variable-number tandem-repeat analysis (MLVA), amplified fragment length polymorphism (AFLP), surface layer protein A gene sequence ( slpA ST), PCR-ribotyping, restriction endonuclease (REA), (MLST), pulsed-field gel electrophoresis (PFGE). We assessed discriminating ability...
Background In the 2003 Toronto SARS outbreak, SARS-CoV was transmitted in hospitals despite adherence to infection control procedures. Considerable controversy resulted regarding which procedures and behaviours were associated with greatest risk of transmission. Methods A retrospective cohort study conducted identify factors for transmission during intubation from laboratory confirmed patients HCWs involved their care. All requiring outbreak identified. who provided care intubated treatment...
Background. Globally, gastroenteritis is recognized as an important contributor to mortality among children, but population-based data on deaths adults and the contributions of specific pathogens are limited. We aimed describe trends in across all ages United States specifically estimate Clostridium difficile norovirus.
Abstract To determine the presence of Clostridium difficile, we sampled cooked and uncooked meat products sold in Tucson, Arizona. Forty-two percent contained toxigenic C. difficile strains (either ribotype 078/toxinotype V [73%] or 027/toxinotype III [NAP1 NAP1-related; 27%]). These findings indicate that food may play a role interspecies transmission.
In the 10 months since first confirmed case of coronavirus disease 2019 (COVID-19) was reported in United States on January 20, 2020 (1), approximately 13.8 million cases and 272,525 deaths have been States. On October 30, number new a single day exceeded 100,000 for time, by December 2 had reached daily high 196,227.* With colder weather, more time spent indoors, ongoing U.S. holiday season, silent spread disease, with 50% transmission from asymptomatic persons (2), has entered phase...
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