A5102947216- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Cardiovascular Health and Disease Prevention
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Peptidase Inhibition and Analysis
- Cerebrovascular and genetic disorders
- Bone health and treatments
- Inflammatory Bowel Disease
- Atrial Fibrillation Management and Outcomes
- MRI in cancer diagnosis
- Cell Adhesion Molecules Research
- Protease and Inhibitor Mechanisms
- Bone health and osteoporosis research
- Venous Thromboembolism Diagnosis and Management
- Cerebral Venous Sinus Thrombosis
- Neonatal Respiratory Health Research
- Moyamoya disease diagnosis and treatment
- COVID-19 and healthcare impacts
- Neuroscience and Neuropharmacology Research
- Migraine and Headache Studies
- Medical Imaging Techniques and Applications
- Neurological and metabolic disorders
University Medical Centre Mannheim
2008-2025
Heidelberg University
2013-2025
University Hospital Heidelberg
2012-2025
Hospital de Clínicas de Porto Alegre
2021
Boston University
2021
Grady Memorial Hospital
2021
Boston Medical Center
2021
Universidade Federal do Rio Grande do Sul
2021
Fraunhofer Institute for Digital Medicine
2015
University of Bremen
2015
Diffusion-weighted MRI (DWI) and perfusion (PI) have been mainly applied in acute stroke, but may provide information the peri-ictal phase epilepsy patients. Both transient reductions of brain water diffusion, namely a low apparent diffusion coefficient (ADC), signs hyperperfusion reported experimental human case studies. We studied 10 patients with complex partial status epilepticus (CPSE) serial including DWI PI. All showed regional hyperintensity on DWI, reduction ADC (i) hippocampal...
Diffusion-weighted (DW) MRI is a sensitive method that facilitates early stroke pattern identification. There are limited data about the influence of stenosis grade on development particular patterns in internal carotid artery (ICA) disease. We therefore investigated lesion DW acute patients with ICA disease.DW was analyzed 102 consecutive different degrees ipsilateral Patients were assigned to 1 5 observed patterns: (1) territorial ischemia, (2) subcortical ischemia without or (3) embolus...
Migrainous infarction is considered a rare complication of migraine. Although several studies reported silent brain lesions on neuroimaging in patients with migraine aura, knowledge about lesion patterns acute migrainous scarce. We investigated clinical and MRI characteristics series migraine-associated cerebral ischemia.Seventeen among 8,137 stroke over an 11-year period were included. All had undergone dedicated workup including diffusion-weighted imaging (DWI) detailed assessment features...
To develop a simple prognostic model to predict outcome at 1 month after acute basilar artery occlusion (BAO) with readily available predictors.The Basilar Artery International Cooperation Study (BASICS) is prospective, observational, international registry of consecutive patients who presented an symptomatic and radiologically confirmed BAO. We considered predictors hospital admission in multivariable logistic regression models poor (modified Rankin Scale [mRS] score 4-5 or death) month....
Abstract Background A growing number of neuroimaging studies suggest distinct neural changes in inflammatory bowel diseases (IBDs). Whether such may show similar spatial patterns across features within and between specific IBD is unclear. To address this question, we used multivariate multimodal data fusion analysis to investigate structure/function modulation remitted patients with Crohn's disease (CD) ulcerative colitis (UC). Methods Patients ( n = 46; 31 CD, 15 UC) stable remission 17...
Background and Objective Alterations of brain morphology in Crohn's disease have been reported, but data is scarce heterogenous the possible impact predisposition on development unknown. Assuming a systemic course disease, involvement seems more probable presence extraintestinal manifestations, this question has not yet addressed. The present study examined relationship between structure focused connection with manifestations markers development. Methods In pilot study, brains 15 patients...
Background and Purpose— To evaluate the potential of a new dynamic MRA sequence (DynAngio) based on arterial spin labeling for assessment intracranial collateral flow. Methods— Twelve patients with unilateral internal carotid artery obstruction were investigated. Different patterns flow compared between DynAngio, transcranial color-coded duplex ultrasound, time-of-flight MRA. Results— There was good agreement methods, sensitivities 80% 90%. Small vessels detected more frequently DynAngio to...
Background and Purpose— There are few in vivo data on the pathophysiology of reperfusion during systemic thrombolysis. We monitored time course cerebral perfusion changes patients thrombolysis with repeated arterial spin labeling magnetic resonance imaging. Methods— Ten proximal occlusion within 4.5 hours after symptom onset were prospectively enrolled. All received intravenous imaging examination. Repeated images acquired 60-minute therapy at follow-up 24 to 72 hours. Clinical data,...
ABSTRACT BACKGROUND AND PURPOSE Occlusion of the internal carotid artery (ICA) and stroke may be consequence either local thrombosis due to atherosclerosis or massive embolism. Up date, there are only few reports subsequent recanalization. METHODS We report 12/76 cases acute ICA occlusion leading ischemic stroke, in which early recanalization was identified. Ultrasound MRI findings, therapeutic options, outcome described. RESULTS 10/12 patients showed an‐ hypoechogenic morphology occlusion....
The objectives of this study were to utilise the XCT-2000 pQCT scanner determine mean values and reproducibility in vivo total, trabecular, cortical volumetric bone measurements at distal diaphyseal sites radius tibia, as well calf muscle subcutaneous fat areas, healthy pre- postmenopausal women.Twenty-nine women (14 premenopausal 15 postmenopausal) recruited participate study. Distal (at 4% 20% length radius) tibia 4%, 38%, 66% tibia) examined.The root square coefficient variation for gave...
ABSTRACT BACKGROUND AND PURPOSE Arterial spin labeling (ASL) MRI provides information on tissue perfusion by consecutive readout of labeled blood captured in arteries or the microvasculature without using contrast agents. METHODS We used a single‐shot 3D acquisition and technique for ASL with multiple inflow times (TI) to evaluate hemodynamic compromise dynamics arterial expressed bolus arrival time (BAT). Thirty‐six patients ischemic stroke were examined standard multimodal protocol...
A 37-year-old woman presented 90 minutes after acute onset of mild motor aphasia with word-finding difficulties and hypesthesia the right arm.MRI was immediately performed as she within 3-hour time window for IV thrombolysis.Diffusion-weighted images (DWI) were normal, but perfusion MRI (dynamic susceptibility contrast) sequences showed marked hypoperfusion in left hemisphere affecting both middle cerebral artery posterior (PCA) territories.These findings considered compatible migraine...
<i>Objective: </i>An inflammatory host response in the ischemically injured brain is well documented. However, its pathophysiological relevance uncertain. We investigated whether leukocyte ischemic alters infarct size. <i>Methods:</i> The cellular to cerebral ischemia Wistar-derived rats induced by transient occlusion of middle artery with a thread was pharmacologically upmodulated lipopolysaccharide (LPS) or downmodulated continuous infusion carboxylated sialyl...