A5029019028- Inflammatory Bowel Disease
- Microscopic Colitis
- Immune Cell Function and Interaction
- Gastrointestinal motility and disorders
- Gut microbiota and health
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Liver Disease and Transplantation
- Mass Spectrometry Techniques and Applications
- Helicobacter pylori-related gastroenterology studies
- Microtubule and mitosis dynamics
- Pancreatitis Pathology and Treatment
- Eosinophilic Esophagitis
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Hemodynamic Monitoring and Therapy
- Metabolomics and Mass Spectrometry Studies
- Pancreatic and Hepatic Oncology Research
- Renal function and acid-base balance
- Liver Disease Diagnosis and Treatment
- Digestive system and related health
- Clostridium difficile and Clostridium perfringens research
- IL-33, ST2, and ILC Pathways
- Gastrointestinal disorders and treatments
- Analytical Chemistry and Chromatography
University Medical Centre Mannheim
2016-2025
Heidelberg University
2016-2025
University Hospital Heidelberg
2016-2025
Medizinische Fakultät Mannheim
2015-2023
Boehringer Ingelheim (Germany)
2019-2023
Evotec (Germany)
2014-2019
University of Mannheim
2017
Lawrence Berkeley National Laboratory
2009-2015
Max Planck Institute of Biochemistry
2008-2015
Klinikum rechts der Isar
2005-2014
Obesity and its associated comorbidities represent a global health challenge with need for well-tolerated, effective, mechanistically diverse pharmaceutical interventions. Oxyntomodulin is gut peptide that activates the glucagon receptor (GCGR) glucagon-like peptide-1 (GLP-1R) reduces bodyweight by increasing energy expenditure reducing intake in humans. Here we describe pharmacological profile of novel (GCGR)/GLP-1 dual agonist BI 456906.BI 456906 was characterized using cell-based vitro...
Dendritic cells (DCs)**Abbreviations used in this paper: BM, bone marrow; CHS, contact hypersensitivity; cLN, cutaneous lymph node; CRP, C-reactive protein; DC, dendritic cell; DNFB, dinitrofluorobenzene; EGFP, enhanced green fluorescent LC, Langerhans LP, lamina propria; MACS, magnetic-activated cell sorting; mLN, mesenteric ODN, oligodeoxynucleotide; PFA, paraformaldehyde; PP, Peyer's patch; TLR, Toll-like receptor; TRITC, tetramethylrhodamine-5-(and-6-)-isothiocyanate. fulfill an...
In this STARDUST substudy, the effect of ustekinumab on transmural bowel inflammation was assessed in adults with moderate-to-severe Crohn's disease (CD) by using intestinal ultrasound (IUS), a noninvasive imaging procedure.STARDUST an international, multicenter, phase 3b, interventional, randomized controlled trial specifically designed to compare treat-to-target and standard-of-care treatment strategies ustekinumab-treated CD patients. most affected segment at baseline IUS used for all...
Abstract Background Extraintestinal symptoms (EIS) in inflammatory bowel diseases, including fatigue, depression and anxiety, are highly prevalent, but poorly understood. Alterations of brain function may contribute to EIS, their association with disease activity is unclear. This study analyzed intrinsic neural (INA) individuals Crohn’s (CD) different states examined the relationship between INA EIS. Methods Patients CD (n = 92) healthy controls 41) underwent functional magnetic resonance...
Expression of the Helicobacter pylori outer membrane protein HopH is regulated by phase variation within a CT dinucleotide repeat motif hopH gene.To investigate importance for bacterial pathogenicity, we performed detailed functional genomic and population-based genetic characterization this contingency locus.Sequencing in H. strains from 58 patients revealed that "on" genotype linked to virulence determinants, such as vacAs1, vacAm1, babA2, and, most strongly, cagA genotypes. mutagenesis...
Obstacles overcome: Gene-specific transcription factors are emerging therapeutic targets, but their direct inhibition is considered to be difficult because of the absence enzymatic activities. This manuscript describes discovery chromone-based inhibitors protein–protein interactions required for activity factor STAT5, a target treatment human cancers. Supporting information this article available on WWW under http://www.wiley-vch.de/contents/jc_2268/2008/z700701_s.pdf or from author. Please...
The detection of high titers antibodies against small nuclear ribonucleoproteins (snRNP) is a diagnostic finding in patients whom systemic lupus erythematosus (SLE) suspected. Endogenous RNA molecules within snRNP trigger Toll-like receptor 7 (TLR-7) activation B cells and dendritic cells, leading to anti-snRNP antibody production, which associated with the development immune complex nephritis SLE. purpose this study was investigate role TLR-7 production renal disease SLE induced by an...
Abstract Helicobacter pylori infection leads to chronic gastric inflammation. The current study determined the response of human APCs, NK cells, and T cells toward bacteria in vitro. Human monocyte-derived dendritic (DC) were incubated with for 48 h. Intact H. at a multitude 5 stimulated expression MHC class II (4- 7-fold), CD80, CD86 B7 molecules (10- 12-fold) CD83 costimulatory molecule (>30-fold) as well IL-12 secretion (>50-fold) DCs, thereby, strongly induced their...
Objective: Volume depletion and/or increased hematocrit are associated with poor prognosis in necrotizing pancreatitis. Several studies suggest that intrathoracic blood volume index (ITBI) might be superior to central venous pressure (CVP) regard preload assessment. Therefore, the aim of our study was evaluate predictive value CVP and ITBI, correlate these parameters cardiac (CI). Design: Prospective study. Setting: Medical intensive care unit, university hospital. Patients Interventions:...
Abstract Introduction Circulatory dysfunction in cirrhotic patients may cause a specific kind of functional renal failure termed hepato-renal syndrome (HRS). It contributes to the high incidence intensive care unit (ICU) patients. Fluid therapy aggravate by increasing ascites and intra-abdominal pressure (IAP). This study investigates short-term effects paracentesis on haemodynamics kidney function volume resuscitated with HRS. Methods Nineteen consecutive HRS were studied. parameters...
Plasmacytoid dendritic cells (PDCs) have been shown to present Ags and contribute peripheral immune tolerance Ag-specific adaptive immunity. However, modulation of responses by selective Ag targeting PDCs with the aim preventing autoimmunity has not investigated. In current study, we demonstrate that in vivo delivery murine via specifically expressed surface molecule sialic acid binding Ig-like lectin H (Siglec-H) inhibits Th cell Ab presence strong stimulation an manner. Correlating...
We present an acoustic ejection mass spectrometry (AEMS) setup for contactless electrospray ionization (ESI-MS)-based sample injection at a sampling rate faster than current ESI and matrix-assisted laser desorption (MALDI) techniques. For the direct transfer of samples out 384-well plates into modified source, open port interface (OPI) was combined with droplet (ADE) system. AEMS has potential to eliminate bottlenecks known from classical MS approaches, such as speed, reproducibility,...
Acoustic droplet ejection (ADE)–open port interface (OPI)–mass spectrometry (MS) has recently been introduced as a versatile analytical method that combines fast and contactless acoustic sampling with sensitive accurate electrospray ionization (ESI)–MS-based analyte detection. The potential of the technology to provide label-free measurements in subsecond cycle times makes it an attractive option for high-throughput screening (HTS). Here, we report first implementation ADE-OPI-MS fully...
Abstract Background Extraintestinal symptoms are common in inflammatory bowel diseases (IBD) and include depression fatigue. These highly prevalent especially active disease, potentially due to inflammation-mediated changes the microbiota-gut-brain axis. The aim of this study was investigate associations between structural functional microbiota characteristics severity fatigue depressive patients with IBD. Methods We included clinical data 62 prospectively enrolled IBD an disease state....