A5068189064- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Venous Thromboembolism Diagnosis and Management
- Cerebral Venous Sinus Thrombosis
- Autoimmune Neurological Disorders and Treatments
- Moyamoya disease diagnosis and treatment
- Stroke Rehabilitation and Recovery
- Neurosurgical Procedures and Complications
- Peripheral Neuropathies and Disorders
- Neurological Complications and Syndromes
- Vasculitis and related conditions
- Cerebrovascular and genetic disorders
- S100 Proteins and Annexins
- Protease and Inhibitor Mechanisms
- Vascular Malformations Diagnosis and Treatment
- Genetics and Neurodevelopmental Disorders
- RNA regulation and disease
- Neurological and metabolic disorders
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Issues in Pregnancy
- Neuroscience of respiration and sleep
- Renal and Vascular Pathologies
Klinikum Ingolstadt
2014-2024
St. Josef-Hospital
2022
Ruhr University Bochum
2022
Ludwig-Maximilians-Universität München
2009-2021
Universitätsklinikum Würzburg
2021
University Hospital Regensburg
2021
University Hospital Bonn
2021
Kiel University
2021
Goethe University Frankfurt
2021
Medizinische Hochschule Hannover
2021
<h3>Background and Objectives</h3> To determine the real-world use of rituximab in autoimmune encephalitis (AE) to correlate treatment with long-term outcome. <h3>Methods</h3> Patients NMDA receptor (NMDAR)-AE, leucine-rich glioma-inactivated-1 (LGI1)- AE, contactin-associated protein-like-2 (CASPR2)-AE, or glutamic acid decarboxylase 65 (GAD65) disease from GErman Network for Research on AuToimmune Encephalitis who had received at least 1 dose a control cohort non–rituximab-treated patients...
Intravenous recombinant tissue plasminogen activator (rtPA) can be beneficial in ischemic stroke despite an increased risk of hemorrhage and potential neurotoxic effects. We hypothesized that rtPA-mediated adverse effects depend on the timing reperfusion injury to blood-brain barrier (BBB).Male Wistar rats had middle cerebral artery occlusion (MCAO) by intraluminal thread placement. Intervals ischemia/reperfusion, respectively, hours were 0/18, 1.5/16.5, 3/15, 6/12, 18/0, 6/1. Animals...
Background and Purpose— The frequent use of a longer time window for recanalization therapy in patients with basilar artery occlusion (BAO) daily practice is not supported by any scientific evidence. We investigated the relationship between to functional outcome BAO data from Basilar Artery International Cooperation Study (BASICS). Methods— BASICS prospective multicenter registry (n=619) radiologically confirmed BAO. analyzed receiving intravenous thrombolysis or intra-arterial treatment....
Decompressive craniectomy is an effective therapy to relieve intractable intracranial hypertension following acute brain injury. However, little known about the optimal timing for cranioplasties in sub-acute phase. The objective of present study was analyse effect cranioplasty on neurological outcomes.Single-centre observational study.One hundred and forty-seven consecutive patients with decompressive during course inpatient neurorehabilitation were identified by means a retrospective...
<b>BACKGROUND AND PURPOSE:</b> With its highly variable clinical presentation, the diagnosis of cerebral venous sinus thrombosis (SVT), and especially deep (DVT), as rare but important causes stroke is challenging. Because noncontrast cranial CT (NCCT) still imaging technique choice in most emergency departments, we aimed to investigate value SVT DVT. <b>MATERIALS METHODS:</b> Screening our patient data base, identified 8 patients with DVT 25 SVT. We also included a control group 36 who had...
Background and Purpose— Suboccipital decompressive craniectomy (SDC) is a life-saving intervention for patients with malignant cerebellar infarction. However, long-term outcome has not been systematically analyzed. Methods— In this monocentric retrospective study we analyzed mortality, functional outcome, quality of life all consecutive that were treated by SDC infarction in our institution between 1995 2006. Results— A total 57 identified. All them bilateral SDC. An external ventricular...
Background and Purpose— The posterior circulation Acute Stroke Prognosis Early CT Score (pc-ASPECTS) quantifies the extent of early ischemic changes in with a 10-point grading system. We hypothesized that pc-ASPECTS applied to angiography source images predicts functional outcome patients Basilar Artery International Cooperation Study (BASICS). Methods— BASICS was prospective, observational registry consecutive acute symptomatic basilar artery occlusion. Functional assessed at 1 month. for...
Intracranial vascular complications are an important complication of acute bacterial meningitis. Ischemic stroke in meningitis is reported as a result vasculitis, vasospasm, endocarditis or intraarterial thrombosis. The aim the study was to identify value measuring cerebral blood flow velocity (CBFv) on transracranial doppler (TCD) identification patients at risk for meningitis-associated stroke.We retrospectively studied with who were treated our university hospital from 2000 2009. Data...
Background and Purpose— In acute basilar artery occlusion, intra-arterial thrombolysis or endovascular mechanical recanalization may result in higher rates than intravenous thrombolysis. However, many patients are admitted to community hospitals, where therapy is usually not readily available. We initiated a “drip, ship, retrieve” cooperative treatment protocol 2006, which was the hospital with simultaneous referral our stroke center use of as required. Methods— The outcome all consecutive...
To develop a simple prognostic model to predict outcome at 1 month after acute basilar artery occlusion (BAO) with readily available predictors.The Basilar Artery International Cooperation Study (BASICS) is prospective, observational, international registry of consecutive patients who presented an symptomatic and radiologically confirmed BAO. We considered predictors hospital admission in multivariable logistic regression models poor (modified Rankin Scale [mRS] score 4-5 or death) month....
Following mechanical recanalization of an acute intracranial vessel occlusion, hyperattenuated lesions are frequently found on postinterventional cranial CT. They represent either blood or-more frequently-enhancement contrast agent. Here, we aimed to evaluate the prognostic value these intracerebral lesions.One hundred one consecutive patients with stroke in anterior circulation who underwent were included. Risk factors for assessed, and lesion volume was compared final infarction. Clinical...
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukencephalopathy (CADASIL) is a hereditary angiopathy caused by mutations in Notch3. microvessels show an accumulation of granular osmiophilic material the vicinity degenerating vascular smooth muscle cells. To study cerebrovascular function CADASIL, we performed measurements on cerebral hemodynamics using transcranial Doppler sonography.Middle artery (MCA) mean blood flow velocity (MFV), CO(2) reactivity, resistance...
To define the location and extent of microvascular damage basal lamina after cerebral ischemia reperfusion in rats, authors subjected animals (n = 16) to 3 hours focal 24 using suture middle artery occlusion model; sham-operated served as controls 6). The Western blot technique was used collagen type IV protein content various brain regions, whereas immunohistochemistry identified loss (anticollagen staining). quantified by automatic morphometric video-imaging analysis. Statistical analysis...
The prognosis of acute basilar artery occlusion (BAO) is poor if early recanalization not achieved. Recanalization strategies include intravenous thrombolysis (IVT) and intra-arterial thrombolysis, as well endovascular mechanical thrombectomy (EMT). combination IVT with consecutive on-demand EMT may allow for treatment initiation high rates but has never been systematically tested in patients BAO.Starting January 2006, we treated all eligible BAO admitted to our academic stroke center or one...
Introduction: Differential diagnoses of the reversible cerebral vasoconstriction syndrome (RCVS) include all forms intracranial stenotic disease, such as primary or secondary vasculitis central nervous system. Here, we tested hypothesis that angiographic response to intra-arterial nimodipine application may be helpful in differentiating between RCVS and other entities. Methods: A digital subtraction (DSA) series nine consecutive patients with suspected were treated by due clinical worsening...
Previously proposed classifications for carotid plaque and cerebral parenchymal hemorrhages are used to estimate the age of hematoma according its signal intensities on T1w T2w MR images. Using these classifications, we systematically investigated value cardiovascular magnetic resonance (CMR) in determining vessel wall (VWH) patients with spontaneous cervical artery dissection (sCAD). 35 consecutive (mean 43.6 ± 9.8 years) sCAD received a multi-sequence 3T CMR fat-saturated black-blood T1w-,...
Vessel wall inflammation (VWI) may be a pathogenetic factor in cervical artery dissection (CAD). We used contrast-enhanced high-resolution MRI (hrMRI) and positron emission tomography CT (PET-CT) to systematically investigate VWI spontaneous CAD.In this monocentric, prospective, observational study, all consecutive patients with acute, MRI-confirmed, CAD admitted our center between August 2007 2009 were included. was defined as perivascular contrast enhancement hrMRI increased...
Single case reports suggest that black blood MRI (T1-weighted fat and suppressed sequences with without contrast injection; BB-MRI) may visualize intracranial vessel wall enhancement (CE) in primary angiitis of the central nervous system (PACNS). In this single-center observational pilot study we prospectively investigated value BB-MRI diagnosis large artery PACNS.Patients suspected PACNS received a standardized diagnostic program including BB-MRI. Vessel CE was graded (grade 0-2) by two...
ABSTRACT BACKGROUND AND PURPOSE The posterior circulation Acute Stroke Prognosis Early CT Score (pc‐APECTS) applied to angiography source images (CTA‐SI) predicts the functional outcome of patients in Basilar Artery International Cooperation Study (BASICS). We assessed diagnostic and prognostic impact pc‐ASPECTS perfusion (CTP) BASICS registry population. METHODS CTA‐SI cerebral blood flow (CBF), volume (CBV), mean transit time (MTT) parameter maps with CTA CTP studies performed....