Wolf‐Dirk Niesen
A5016972938- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Cardiac Arrest and Resuscitation
- Cerebrospinal fluid and hydrocephalus
- Organ Donation and Transplantation
- Long-Term Effects of COVID-19
- Thermal Regulation in Medicine
- Cerebral Venous Sinus Thrombosis
- Photoacoustic and Ultrasonic Imaging
- Respiratory Support and Mechanisms
- Cardiovascular Health and Disease Prevention
- Vascular Malformations Diagnosis and Treatment
- Tracheal and airway disorders
- Peripheral Neuropathies and Disorders
- Diet and metabolism studies
- Airway Management and Intubation Techniques
- Neurological disorders and treatments
- Head and Neck Surgical Oncology
- Migraine and Headache Studies
University Medical Center Freiburg
2016-2025
University of Freiburg
2016-2025
Klinik und Poliklinik für Neurologie
2019
Essen University Hospital
2015-2017
University Hospital Heidelberg
2017
Heidelberg University
2017
May Institute
2015
Medical University of Vienna
2015
Vrije Universiteit Brussel
2015
Center for Neurosciences
2015
After aneurysmal subarachnoid hemorrhage, the use of lumbar drains has been suggested to decrease incidence delayed cerebral ischemia and improve long-term outcome.To determine effectiveness early cerebrospinal fluid drainage added standard care in patients after hemorrhage.The EARLYDRAIN trial was a pragmatic, multicenter, parallel-group, open-label randomized clinical with blinded end point evaluation conducted at 19 centers Germany, Switzerland, Canada. The first patient entered January...
Many patients with severe stroke have impaired airway protective reflexes, resulting in prolonged invasive mechanical ventilation.To test whether early vs standard tracheostomy improved functional outcome among receiving ventilation.In this randomized clinical trial, 382 acute ischemic or hemorrhagic ventilation were randomly assigned (1:1) to (≤5 days of intubation) ongoing ventilator weaning if needed from day 10. Patients between July 28, 2015, and January 24, 2020, at 26 US German...
We explored the safety of intravenous thrombolysis (IVT) or intra-arterial treatment (IAT) in patients with ischemic stroke on non-vitamin K antagonist oral anticoagulants (NOACs, last intake <48 hours) comparison (1) taking vitamin antagonists (VKAs) (2) without previous anticoagulation (no-OAC).This is a multicenter cohort pilot study. Primary outcome measures were occurrence intracranial hemorrhage (ICH) 3 categories: any ICH (ICHany), symptomatic according to criteria European...
<i>Background:</i> To investigate whether there is: (1) a specific temporal course of cerebral dysautoregulation in acute ischemic stroke, and (2) separate detrimental effect recombinant tissue plasminogen activator (rtPA) on autoregulation dynamics this situation. <i>Methods:</i> We studied 16 patients with middle artery (MCA) occlusion rtPA thrombolysis (intra-arterial or intravenous application, both). Controls were 71 healthy adults 11 minor stroke not receiving...
Background and purpose Cerebral infarction is a frequent serious complication of aneurysmal subarachnoid hemorrhage ( SAH ). This study aimed to identify independent predictors the timing cerebral clarify its impact on disease course patients’ outcome. Methods All consecutive patients with admitted our institution from January 2005 December 2012 were analyzed. Serial computed tomography CT ) scans evaluated for infarctions. Demographic, clinical, laboratory radiological data during...
Cerebral infarction (CI) is a crucial complication of aneurysmal subarachnoid hemorrhage (SAH) associated with poor clinical outcome. We aimed at developing an early risk score for CI based on characteristics available the onset SAH. Out database containing 632 consecutive patients SAH admitted to our institution from January 2005 December 2012, computed tomography (CT) scans up day 42 after ictus were evaluated CIs. Different parameters admission aneurysm treatment collected subsequent...
Background Tracheostomy is a common procedure in long-term ventilated critical care patients and frequently necessary those with severe stroke. The optimal timing for tracheostomy still unknown, it controversial whether early impacts upon functional outcome. Method Stroke-related Early vs. Prolonged Orotracheal Intubation Neurocritical Trial 2 (SETPOINT2) multicentre, prospective, randomized, open-blinded endpoint (PROBE-design) trial. Patients acute ischemic stroke, intracerebral hemorrhage...
Hypercoagulability in Coronavirus Disease 2019 (COVID-19) causes deep vein thrombosis and pulmonary embolism necessitating systemic anticoagulation. Case reports of intracerebral hemorrhages ventilated COVID-19 patients warrant precaution. It is unclear, however, if with acute respiratory distress syndrome (ARDS) or without veno-venous extracorporeal membrane oxygenation therapy (VV-ECMO) have more (ICH) compared to other ARDS patients.
Abstract Background and objectives In 2020, a wide range of hygiene measures was implemented to mitigate infections caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). consequence, pulmonary due other pathogens also decreased. Here, we evaluated number bacterial viral meningitis encephalitis cases during disease 2019 (COVID-19) pandemic. Methods multicentre retrospective analysis data from January 2016 until December numbers patients diagnosed with types CNS (such as...
Background Detecting an anterior circulation large-vessel occlusion (aLVO) as a cause of stroke during emergency calls could optimise dispatch, particularly in rural areas. Numerous severity scales assessing motor and cortical signs have been designed for direct patient contact; however, none purposely calls. This study aimed to prospectively validate the novel Freiburg Neurointerventional Score (FRENS) patients presenting with suspected acute detect aLVO. Methods Patients aged ≥18 years...
Along with subarachnoid hemorrhage (SAH), a ruptured aneurysm may also cause an intracerebral hematoma (ICH), which negatively impacts the functional outcome of SAH.To identify independent risk factors aneurysmal ICH.Six hundred thirty-two consecutive patients SAH treated at our institution from January 2005 to December 2012 were eligible for this study. Demographic parameters and preexisting comorbidities patients, as well various clinical radiographic characteristics correlated incidence...