A5022740866- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- S100 Proteins and Annexins
- Traumatic Brain Injury and Neurovascular Disturbances
- Atrial Fibrillation Management and Outcomes
- Glioma Diagnosis and Treatment
- Dysphagia Assessment and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Tracheal and airway disorders
- Esophageal and GI Pathology
- Chromatin Remodeling and Cancer
- Intensive Care Unit Cognitive Disorders
- Cancer, Stress, Anesthesia, and Immune Response
- Venous Thromboembolism Diagnosis and Management
- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- Mechanisms of cancer metastasis
- Botulinum Toxin and Related Neurological Disorders
- Bacterial Infections and Vaccines
- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- Anesthesia and Sedative Agents
- History and Developments in Astronomy
- Blood Coagulation and Thrombosis Mechanisms
- Long-Term Effects of COVID-19
Klinikum Ludwigsburg
2023-2025
University Hospital Frankfurt
2014-2023
Goethe University Frankfurt
2014-2023
University Hospital Augsburg
2021
German Cancer Research Center
2014
Deutschen Konsortium für Translationale Krebsforschung
2013
Significance N -myc downstream regulated gene 1 (NDRG1) is a central and druggable molecular hub integrating diverse therapy-induced microenvironmental factors to promote resistance toward alkylating chemotherapy. We suggest that NDRG1-mediated chemoprotection achieved via binding stabilizing methyltransferases, such as O 6 -methylguanine-DNA methyltransferase.
Recent studies have suggested that glial fibrillary acidic protein (GFAP) serum concentrations distinguish between intracerebral hemorrhage (ICH) and ischemic stroke (IS) shortly after symptom onset. In this prospective multicenter trial we validated GFAP in an independent patient cohort assessed the quantitative relationship release, bleeding size, localization.We included patients with a persistent neurological deficit (NIH Stroke Scale ≥4) suggestive of within 6 h Blood samples were drawn...
<b><i>Background:</i></b> The novel direct oral anticoagulants (NOA), dabigatran (a thrombin inhibitor), rivaroxaban and apixaban (factor Xa inhibitors) have shown at least noninferiority compared to warfarin concerning the prevention of stroke systemic embolism as well risk hemorrhagic complications in large phase III trials patients with atrial fibrillation (AF). These results been obtained under regular monitoring side effects reinforcement medication adherence...
Abstract Background We aimed to determine the association between seizure termination and side effects of isoflurane for treatment refractory status epilepticus (RSE) super-refractory (SRSE) in neurointensive care units (neuro-ICUs). Methods This was a multicenter retrospective study patients with RSE/SRSE treated admitted neuro-ICUs nine German university centers during 2011–2018. Results identified 45 who received RSE/SRSE. During treatment, electroencephalograms showed no epileptiform...
Abstract Background and objectives In 2020, a wide range of hygiene measures was implemented to mitigate infections caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). consequence, pulmonary due other pathogens also decreased. Here, we evaluated number bacterial viral meningitis encephalitis cases during disease 2019 (COVID-19) pandemic. Methods multicentre retrospective analysis data from January 2016 until December numbers patients diagnosed with types CNS (such as...
Rapid identification and treatment of stroke is crucial for the outcome patient. We aimed to determine performance glial fibrillary acidic protein (GFAP) independently in combination with Prehospital Stroke Score (PreSS) differentiation acute within 4.5 h after symptom onset. Clinical data serum samples were collected from Treat-Norwegian Acute Project (Treat-NASPP). Patients suspected symptoms lasting ≤ had blood evaluated National Institutes Health Scale prospectively. In this sub study,...
Abstract Background Prehospital triage and treatment of patients with acute coma is challenging for rescue services, as the underlying pathological conditions are highly heterogenous. Recently, glial fibrillary acidic protein (GFAP) has been identified a biomarker intracranial hemorrhage. The aim this prospective study was to test whether prehospital GFAP measurements on point-of-care device have potential rapidly differentiate hemorrhage from other causes coma. Methods This conducted at RKH...
Introduction: The rapid identification of acute intracerebral hemorrhage (ICH) in patients with symptoms stroke is decisive for prehospital triage and initiation targeted therapies. Glial fibrillary acidic protein (GFAP) a highly promising blood biomarker indicating ICH. In this study we investigated the potential new GFAP point-of-care test rapidly distinguishing ICH from ischemic (IS) mimics phase. Methods: Acute admitted within 6 hours symptom onset were enrolled. Blood samples collected...
Background: The astroglial protein GFAP (glial fibrillary acidic protein) is a promising biomarker candidate for prehospital differentiation between intracerebral hemorrhage (ICH) and ischemic stroke. rapidly released into plasma from disrupted astrocytes in expanding ICH, but increases more slowly following cell necrosis. Besides hematoma volume, factors associated with release acute ICH have not been explored. It has noted previous studies that certain proportion of patients did show...
Little is known about the frequency and clinical characteristics of neurogenic dysphagia in pontine strokes. In this study, we sought to identify predictors for a cohort patients with isolated infarctions.We included all admitted our department between 2008 2014 having an acute (<48 hours after symptom onset) ischemic stroke pons, as documented by means diffusion-weighted magnetic resonance imaging. Precise infarct localization was stratified according established vascular territories. The...
// Anna-Luisa Thiepold 1 , Sebastian Luger 2 Marlies Wagner 3 Natalie Filmann 4 Michael W. Ronellenfitsch Patrick N. Harter 5 Anne K. Braczynski Stephan Dützmann 6 Elke Hattingen Joachim P. Steinbach Christian Senft Johannes Rieger and Oliver Bähr Dr. Senckenberg Institute of Neurooncology, Goethe-University Hospital, Frankfurt, Germany Department Neurology, Neuroradiology, Biostatistics Mathematical Modeling, Edinger Institute, Neurosurgery, Correspondence to: Bähr, email: Keywords :...
Background: Oral anticoagulant therapy (OAT) potently prevents strokes in patients with atrial fibrillation. Vitamin K antagonists (VKA) have been the standard of care for long-term OAT decades, but non-VKA oral anticoagulants (NOAC) recently approved this indication, and raised many questions, among them their influence on medication adherence. We assessed adherence to VKA NOAC secondary stroke prevention. Methods: All treated from October 2011 September 2012 ischemic or transient attack a...
Background Direct oral anticoagulants (DOAC) are alternatives to the use of vitamin K antagonists (VKA) as anticoagulant therapies prevent stroke in patients with atrial fibrillation. Aims We assembled a representative secondary prevention cohort from four tertiary care centers identify factors that independently influence therapeutic decision making 1) not anticoagulate either VKA or DOAC and 2) if patient appears suitable for therapy. Methods identified all discharged diagnoses ‘ischemic...
Despite the efficacy of neuroprotective approaches in animal models stroke, their translation has so far failed from bench to bedside. One reason is presumed be a low quality preclinical study design, leading bias and priori power. In this study, we propose that key read-out experimental stroke studies, volume ischemic damage as commonly measured by free-handed planimetry TTC-stained brain sections, subject an unrecognized inter-rater test-retest reliability with strong implications for...
To establish serum concentration of protein S100B as an objective biomarker surrogate for astroglial tissue damage after mechanical thrombectomy in patients with acute ischemic stroke.This prospective 2-center study recruited middle cerebral artery infarctions caused by large vessel occlusion treated thrombectomy. Blood samples were collected at day 2 intervention and analyzed concentrations using ELISA techniques. Infarct size was determined on follow-up brain imaging functional outcome...
Abstract Dysphagia is common in patients with middle cerebral artery (MCA) infarctions and associated malnutrition, pneumonia, mortality. Besides bedside screening tools, brain imaging findings may help to timely identify swallowing disorders. We investigated whether the Alberta stroke program early CT score (ASPECTS) allows for correlation of distinct ischemic lesion patterns dysphagia. prospectively examined 113 consecutive acute MCA infarctions. Fiberoptic endoscopic evaluation (FEES) was...
Sphingolipids are versatile signaling molecules derived from membrane lipids of eukaryotic cells. Ceramides regulate cellular processes such as proliferation, differentiation and apoptosis involved in stress responses. Experimental evidence suggests a pivotal role sphingolipids the pathogenesis cardiovascular diseases, including ischemic stroke. A neuroprotective effect has been shown for beta-adrenergic antagonists rodent stroke models supported by observational clinical data. However,...
Background: A reliable distinction between ischemic stroke (IS) and intracerebral hemorrhage (ICH) is required for diagnosis-specific treatment effective secondary prevention in patients with stroke. However, resource-limited settings brain imaging, which the current diagnostic gold standard this purpose, not always available time. Hence, an easily accessible broadly applicable blood biomarker-based test differing subtypes would be desirable. Using explorative proteomics approach, pilot...
Background: The rapid differentiation between intracerebral hemorrhage (ICH) and ischemic stroke (IS) in patients with symptoms of acute is decisive for triage initiation targeted therapies. Glial fibrillary acidic protein (GFAP) a highly promising blood biomarker indicating ICH. In this study we investigated the potential new GFAP plasma test on point-of-care (POC) platform rapidly distinguishing ICH from IS prehospital phase. Methods: Patients admitted within 6 hours symptom onset were...
Cytotoxic T lymphocytes take on a leading role in many immune-related diseases. They function as key effector immune cells fighting cancer cells, but they are also considerably involved autoimmune Common to both situations, CD8+ need adapt their metabolism and the harsh nutrient-deprived conditions of disease-associated microenvironment.We used an vitro starvation well rapamycin treatment protocol mimicking nutrient deprivation generate CD8Low versus CD8High performed FACS-Sorting followed...
Patients with glioblastoma are exposed to severe symptoms and organs failures (e.g., coma or acute respiratory failure), that may require intensive care unit (ICU) admission invasive mechanical ventilation (IMV). However, only limited data available concerning the prognosis of patients receiving IMV. We sought describe reasons for ICU admission, outcomes requiring IMV unplanned critical complications.In this retrospective analysis, four certified interdisciplinary brain tumor centers...
Backround: Essential Tremor (ET) is a progressive neurological disorder characterized by postural and kinetic tremor most commonly affecting the hands arms. Medically intractable ET can be treated deep brain stimulation (DBS) of ventral intermediate nucleus thalamus (VIM). We investigated whether location effective contact (most suppression with at least side effects) in VIM-DBS for changes over time, indicating distinct mechanism loss efficacy that goes beyond progression severity, or mere...