A5083688199- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Traumatic Brain Injury and Neurovascular Disturbances
- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Intensive Care Unit Cognitive Disorders
- Cerebrospinal fluid and hydrocephalus
- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Mechanical Circulatory Support Devices
- Anesthesia and Sedative Agents
- Management of metastatic bone disease
- Acute Ischemic Stroke Management
- Meningioma and schwannoma management
- Epilepsy research and treatment
- Crystallography and molecular interactions
- Intracranial Aneurysms: Treatment and Complications
- Inflammatory Biomarkers in Disease Prognosis
- Electrolyte and hormonal disorders
- Palliative Care and End-of-Life Issues
- Bacterial Infections and Vaccines
- Lung Cancer Treatments and Mutations
- Respiratory Support and Mechanisms
University Hospital Bonn
2019-2025
University of Bonn
2019-2023
Unfallkrankenhaus Berlin
2023
Ortenau Klinikum
2022
Zimmer Biomet (Germany)
2022
Goethe University Frankfurt
2014
Kantonsspital Baselland
1996
Abstract Background Recently, a randomized controlled trial (RCT) demonstrated rapid but individually variable hemodynamic improvement with therapeutic plasma exchange (TPE) in patients septic shock. Prediction of clinical efficacy specific sepsis treatments is fundamental for individualized therapy. Methods In the original RCT, shock < 24 h duration and norepinephrine (NE) requirement ≥ 0.4 μg/kg/min received standard care (SOC) or SOC + one single TPE. Here, we report all biological...
Neurosurgical resection represents an important therapeutic pillar in patients with brain metastasis (BM). Such extended treatment modalities require preoperative assessment of patients’ physical status to estimate individual success. The aim the present study was analyze predictive value frailty and sarcopenia as tools for physiological integrity non-small cell lung cancer (NSCLC) who had undergone surgery BM. Between 2013 2018, 141 were surgically treated BM from NSCLC at authors’...
Given the ongoing global SARS-CoV-2-vaccination efforts, clinical awareness needs to be raised regarding possibility of an increased incidence SARS-CoV-2-vaccine-related immune-mediated thrombocytopenia in patients with intracerebral hemorrhage (ICH) secondary cerebral sinus and vein thrombosis (CVT) requiring (emergency) neurosurgical treatment context vaccine-induced immune thrombotic (VITT). Only recently, association vaccinations has been described. In a number cases, is warranted for...
Abstract Background We aimed to determine the association between seizure termination and side effects of isoflurane for treatment refractory status epilepticus (RSE) super-refractory (SRSE) in neurointensive care units (neuro-ICUs). Methods This was a multicenter retrospective study patients with RSE/SRSE treated admitted neuro-ICUs nine German university centers during 2011–2018. Results identified 45 who received RSE/SRSE. During treatment, electroencephalograms showed no epileptiform...
Surgical resection is a key treatment modality for brain metastasis (BM). However, peri- and postoperative adverse events (PAEs) might be associated with detrimental impact on outcome. We retrospectively analyzed our institutional database regard to patient safety indicators (PSIs), hospital-acquired conditions (HACs) specific cranial surgery-related complications (CSCs) as high-quality metric profiles PAEs in patients who had undergone surgery BM department between 2013 2018. The...
Intra-tumoral hemorrhage is considered an imaging characteristic of advanced cancer disease. However, data on the influence intra-tumoral in patients with brain metastases (BM) remains scarce. We aimed at investigating BM who underwent neurosurgical resection metastatic lesion for a potential impact preoperative hemorrhagic transformation overall survival (OS).Between 2013 and 2018, 357 were surgically treated authors' neuro-oncological center. Preoperative magnetic resonance (MRI)...
Patients with brain metastasis (BM) from solid tumors are in an advanced stage of cancer. BM may occur during a known oncological disease (metachronous BM) or be the primary manifestation previously unknown cancer (synchronous BM). The time diagnosis might decisively impact patient prognosis and further treatment stratification. In present study, we analyzed prognostic synchronous versus (vs.) metachronous occurrence following resection BM.Between 2013 2018, 353 patients had undergone...
Sepsis is as a life-threatening organ dysfunction caused by dysregulated host response to an infection. The mortality of sepsis and particular septic shock very high. Treatment mostly focuses on infection control but specific intervention that targets the underlying pathological lacking present time. investigators hypothesize early therapeutic plasma exchange (TPE) will dampen maladaptive removing injurious mediators thereby limiting improving survival in patients with shock. Although small...
Abstract Postoperative intensive care unit (ICU) monitoring is an established option to ensure patient safety after resection of newly diagnosed glioblastoma. In contrast, secondary unplanned ICU readmission following complicating events during the initial postoperative course might be associated with severe morbidity and impair initially intended surgical benefit. present study, we assessed prognostic impact aimed identify preoperatively ascertainable risk factors for development such...
Abstract Background Sepsis and septic shock, defined by a profound immune dysregulation, are among the leading causes of death in intensive care unit (ICU). Despite advances understanding underlying pathophysiology, evidence for specific immunomodulatory treatment does not exist to date. Therapeutic plasma exchange (TPE) represents an adjunctive approach rebalance homeostasis. In EXCHANGE-1 trial, we recently demonstrated rapid hemodynamic improvement, possibly caused removal harmful...
The reaction of 1,2-C6H4(P(O)-t-Bu2)(Li) (Ph*Li) with B(OMe)3 furnishes a mixture Li[Ph*B(OMe)3] (Li[2a]) and Ph*B(OMe)2 (2b). Further treatment Li[AlH4] provides the trihydroborate Li[Ph*BH3] (Li[3]), which can subsequently be converted into intramolecular P═O–B adduct Ph*BH2 (4) through hydride abstraction Me3SiCl. Addition C6F5MgBr yields Mg[Ph*BH2(C6F5)]2 (Mg[5]2), is inert toward Me3SiCl but reacts water to give Ph*B(H)C6F5 (6). Upon addition further C6F5MgBr, formed, from crystals...
Object In the light of an aging population and ongoing advances in cancer control, optimal management geriatric patients with brain metastases (BM) poses increasing challenge, especially due to scarce data available. We therefore analyzed our institutional regard factors influencing overall survival (OS) BM. Methods Between 2013 2018, aged ≥ 65 years surgically treated BM were included this retrospective analysis. search preoperatively identifiable risk for poor OS, addition underlying...
Object: Inflammatory response is an important determinant of subsequent brain injury after deep-seated intracerebral hemorrhage (ICH). The ratio red blood cell (RBC) distribution width to platelet count (RPR) has been established as a new index reflect the severity inflammation. To best our knowledge, no association between RPR and prognosis spontaneous ICH yet reported. Methods: In all patients with treated at Neurovascular Center from 2014 2020, initial laboratory values were obtained...
Extra Corporeal Membrane Oxygenation (ECMO) has become an accepted treatment option for severely ill patients. Due to a limited availability of ECMO support therapy, patients must often be transported specialised centre before or after cannulation. According the ELSO guidelines, specialist should present such interventions. Here we describe safety and efficacy reduced team approach involving one anaesthesiologist, experienced in intensive care medicine, critical nurse. This study is 10 years...
While management of patients with deep-seated intracerebral hemorrhage (ICH) is well established, there are scarce data on ICH who require prolonged mechanical ventilation (PMV) during the course their acute disease. Therefore, we aimed to determine influence PMV mortality in and identify associated risk factors. From 2014 May 2020, all were admitted intensive care for >3 days included further analyses. defined as receiving more than 7 days. A total 42 out 94 (45%) suffered from...
Objective Surgical resection represents a common treatment modality in patients with brain metastasis (BM). Postoperative prolonged mechanical ventilation (PMV) might have an enormous impact on the overall survival (OS) of these suffering from advanced cancer disease. We therefore analyzed our institutional database regard to potential PMV OS who had undergone surgery for metastases. Methods 360 surgically treated metastases were included. The definition consisted postoperative lasting more...
Background: Metastatic melanoma disease is accompanied by highly systemic inflammatory responses. The prognostic value of preoperative laboratory inflammation markers in brain metastatic patients has not been adequately investigated so far. Methods: Preoperative blood parameters were correlated to overall survival (OS) rates that underwent surgery for metastasis (BM) between 2013 and 2019 at the authors’ institution. Receiver operating characteristic (ROC) analyses used cutoff determination...
The conception of individual patient-adjusted treatment strategies is constantly emerging in the field neuro-oncology. Systemic laboratory markers may allow insights into needs and estimated benefit at an earliest possible stage. Therefore, present study was aimed analyzing prognostic significance preoperative routine values patients with newly-diagnosed glioblastoma.Between 2014 2019, 257 were surgically treated for glioblastoma Neuro-Oncology Center University Hospital Bonn. Preoperative...
Abstract Object Postoperative intensive care unit (ICU) monitoring is a common regime after neurosurgical resection of brain metastasis (BM). In comparison, unplanned secondary readmission to the ICU initial postoperative treatment course occurs in response adverse events and might significantly impact patient prognosis. present study, we analyzed potential prognostic implications aimed at identifying preoperatively collectable risk factors for development such events. Methods Between 2013...
Delayed cerebral ischemia (DCI) is a predictor of poor outcome after aneurysmal subarachnoid hemorrhage (SAH). Treatment strategies vary and include induced hypertension invasive endovascular treatment. After the IMCVS trial (NCT01400360), which failed to demonstrate benefit treatment for vasospasm (CVS) resulted in significantly worse outcome, we changed our policy patients with diagnosed CVS only, present prospective results subgroup SAH meeting inclusion criteria trial. All underwent...
Although the treatment of glioblastoma patients is well established in neuro-oncological surgery, precious scarce data available on with requiring postoperative prolonged mechanical ventilation (PMV). Therefore, aim present study was to determine influence PMV overall survival (OS) glioblastoma.Patients newly diagnosed who had undergone surgical therapy and complete subsequent at authors' center from January 2013 December 2018 were selected included further analysis. defined as for more than...
Intracerebral hemorrhage (ICH) is a frequently disabling or fatal disease. The localization of ICH often allows an etiological association. However, in atypical/lobar ICH, the cause bleeding less obvious. Therefore, we present prospective histopathological and radiological studies which were conducted within diagnostic workup to identify causes for lobar other than hypertension. From 2016 2018, 198 patients with spontaneous, non-traumatic requiring neurosurgical monitoring enrolled...