A5006223192- Cardiovascular and Diving-Related Complications
- Heme Oxygenase-1 and Carbon Monoxide
- High Altitude and Hypoxia
- Traumatic Brain Injury and Neurovascular Disturbances
- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Restraint-Related Deaths
- Neonatal Health and Biochemistry
- Management of metastatic bone disease
- Obstructive Sleep Apnea Research
- Aortic Disease and Treatment Approaches
- Cardiac Ischemia and Reperfusion
- Neuroscience of respiration and sleep
- Skin and Cellular Biology Research
- Hemodynamic Monitoring and Therapy
- Fatty Acid Research and Health
- Cardiac Fibrosis and Remodeling
- Epilepsy research and treatment
- Congenital Heart Disease Studies
- Vascular Malformations Diagnosis and Treatment
- Macrophage Migration Inhibitory Factor
- Thermal Regulation in Medicine
- Alcohol Consumption and Health Effects
- Venous Thromboembolism Diagnosis and Management
- Cardiac Arrest and Resuscitation
University Hospital Bonn
2015-2025
Helios Hospital Siegburg
2025
University of Bonn
2014-2020
Gesundheitsdienst
2019
Medical University of Sofia
2019
Alexandrovska Hospital
2019
Medizinische Hochschule Hannover
2018
Dr. A. Ramachandran's Diabetes Hospitals
2018
Ohio University
2016
Despite recent advances in resuscitation algorithms, neurological injury after cardiac arrest due to cerebral ischemia and reperfusion is one of the reasons for poor outcome. There currently no adequate means measuring perfusion during arrest. It was aim this study investigate feasibility near infrared spectroscopy (NIRS) as a potential surrogate parameter patients with out-of-hospital resuscitations physician-staffed emergency medical service.An physician responding emergencies equipped...
Neurosurgical resection represents an important therapeutic pillar in patients with brain metastasis (BM). Such extended treatment modalities require preoperative assessment of patients’ physical status to estimate individual success. The aim the present study was analyze predictive value frailty and sarcopenia as tools for physiological integrity non-small cell lung cancer (NSCLC) who had undergone surgery BM. Between 2013 2018, 141 were surgically treated BM from NSCLC at authors’...
Objective: Waterpipe smoking may increasingly account for unintentional carbon monoxide poisoning, a serious health hazard with high morbidity and mortality. We aimed at identifying waterpipe as cause poisoning in large critical care database of specialty referral center.Methods: This retrospective cohort study included patients history exposure to blood gas levels >10% or presence clinical symptoms compatible CO admitted between January 2013 December 2016. Patients’ initial were retrieved...
Surgical resection is a key treatment modality for brain metastasis (BM). However, peri- and postoperative adverse events (PAEs) might be associated with detrimental impact on outcome. We retrospectively analyzed our institutional database regard to patient safety indicators (PSIs), hospital-acquired conditions (HACs) specific cranial surgery-related complications (CSCs) as high-quality metric profiles PAEs in patients who had undergone surgery BM department between 2013 2018. The...
Intra-tumoral hemorrhage is considered an imaging characteristic of advanced cancer disease. However, data on the influence intra-tumoral in patients with brain metastases (BM) remains scarce. We aimed at investigating BM who underwent neurosurgical resection metastatic lesion for a potential impact preoperative hemorrhagic transformation overall survival (OS).Between 2013 and 2018, 357 were surgically treated authors' neuro-oncological center. Preoperative magnetic resonance (MRI)...
Spinal dorsal instrumentation (SDI) is an established treatment for degenerative spinal diseases. Adequate and immediate postoperative pain control important patient recovery may be compromised by uncertainty about its efficacy concern early surgical complications or adverse events. The aim of the current study was to compare use epidural analgesia (EA) with systemic (SA) as regards reduction after SDI. Pain management in patients undergoing SDI posterior approach between January 2019 July...
C-C chemokine receptor type 2 positive monocytes are recruited from the circulation to infiltrate inflamed tissue. Left ventricular (LV) hypertrophy caused by pressure overload presents with a chronic myocardial inflammation in our mouse model of transverse aortic constriction (TAC). Recent analyses demonstrated that deficiency fractalkine CX3CR1 leads pro-inflammatory phenotype characterized increased numbers Ly6C high macrophages myocardium due CCR2 dependent monocyte recruitment...
Prolonged breath-hold causes complex compensatory mechanisms such as increase in blood pressure, redistribution of flow, and bradycardia. We tested whether apnea induces an elevation catecholamine-concentrations well-trained apneic divers.11 divers performed maximal dry a horizontal position. Parameters measured during included ECG, central, addition to peripheral hemoglobin oxygenation. Peripheral arterial oxygenation was detected by pulse oximetry, whereas (abdominal) central (cerebral)...
Object In the light of an aging population and ongoing advances in cancer control, optimal management geriatric patients with brain metastases (BM) poses increasing challenge, especially due to scarce data available. We therefore analyzed our institutional regard factors influencing overall survival (OS) BM. Methods Between 2013 2018, aged ≥ 65 years surgically treated BM were included this retrospective analysis. search preoperatively identifiable risk for poor OS, addition underlying...
Background Apnea diving has gained worldwide popularity, even though the pathophysiological consequences of this challenging sport on human body are poorly investigated and understood. This study aims to assess influence sustained apnea in healthy volunteers circulating microparticles ( MPs ) microRNAs miRs ), which established biomarkers reflecting vascular function. Hypothesis Short intermittent hypoxia due voluntary breath‐holding affects levels endothelial cell‐derived EMPs . Methods...
To investigate the impact of aortic valve calcification and brain morphology on acute peri-procedural cerebrovascular events (CVEs) in patients undergoing transcatheter implantation (TAVI).Aortic stenosis can be assessed with echocardiography. Cerebral magnetic resonance imaging (MRI) depicts quantifies morphological signs hypoperfusion vascular embolism, which is special interest severe stenosis. Furthermore, subjects who undergo TAVI are prone to suffer clinically silent CVEs.A total 119...
The CX3CL1/CX3CR1 axis mediates recruitment and extravasation of CX3CR1-expressing subsets leukocytes plays a pivotal role in the inflammation-driven pathology cardiovascular disease. cardiac immune response differs depending on underlying causes. This suggests that for development successful immunomodulatory therapy heart failure due to chronic pressure overload induced left ventricular (LV) hypertrophy, patterns must be examined. Here, authors demonstrate Fraktalkine-receptor CX3CR1 is...
Background: Metastatic melanoma disease is accompanied by highly systemic inflammatory responses. The prognostic value of preoperative laboratory inflammation markers in brain metastatic patients has not been adequately investigated so far. Methods: Preoperative blood parameters were correlated to overall survival (OS) rates that underwent surgery for metastasis (BM) between 2013 and 2019 at the authors’ institution. Receiver operating characteristic (ROC) analyses used cutoff determination...
Objective Surgical resection represents a common treatment modality in patients with brain metastasis (BM). Postoperative prolonged mechanical ventilation (PMV) might have an enormous impact on the overall survival (OS) of these suffering from advanced cancer disease. We therefore analyzed our institutional database regard to potential PMV OS who had undergone surgery for metastases. Methods 360 surgically treated metastases were included. The definition consisted postoperative lasting more...
Prolonged breath holding results in hypoxemia and hypercapnia. Compensatory mechanisms help maintain adequate oxygen supply to hypoxia sensitive organs, but burden the cardiovascular system. The aim was investigate human compensatory their effects on system with regard cardiac function morphology, blood flow redistribution, serum biomarkers of adrenergic myocardial injury markers following prolonged apnoea. Seventeen elite apnoea divers performed maximal breath-hold during magnetic resonance...
Research on cardiac hypertrophy and heart failure is frequently based pressure overload mouse models induced by TAC. The standard procedure to perform a partial thoracotomy visualize the transverse aortic arch. However, surgical trauma caused in open-chest changes respiratory physiology as ribs are dissected left unattached after chest closure. To prevent this, we established minimally invasive, closed approach via lateral thoracotomy. Herein arch 2nd intercostal space without entering...
Objective . Myocardial ischemia and reperfusion (I/R) injury is associated with oxidative stress inflammation, leading to scar development malfunction. The marine omega-3 fatty acids ( ω -3 FA), eicosapentaenoic acid (EPA), docosahexaenoic (DHA) are mediating cardioprotection improving clinical outcomes in patients heart disease. Therefore, we tested the hypothesis that supplementation prior LAD occlusion-induced myocardial (MI) confers mice. Methods C57BL/6N mice were placed on DHA or...
Surgical resection is highly effective in the treatment of tumor-related epilepsy (TRE) patients with brain metastases (BM). Nevertheless, some suffer from postoperative persistent which negatively impacts health-related quality life. Therefore, early identification potentially unfavorable seizure outcome after BM important. Patients TRE that had undergone surgery for at authors' institution between 2013 and 2018 were analyzed regard to preoperatively identifiable risk factors outcome. Tumor...
Leksell stereotactic system-based aspiration biopsy is a common procedure in the neurosurgical treatment of deep-seated or multiple brain lesions. This study aimed to evaluate benefit frameless using VarioGuide compared frame-based system (LSS). We analyzed all biopsies LSS at our neurooncological Department Neurosurgery University Hospital Bonn between January 2018 and August 2020. demographic data, duration surgery, size lesion, localization, early complications. Uni-variable analyses were...