A5035911840- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Meningioma and schwannoma management
- Neurosurgical Procedures and Complications
- Neurofibromatosis and Schwannoma Cases
- Spinal Fractures and Fixation Techniques
- Cerebrospinal fluid and hydrocephalus
- Management of metastatic bone disease
- Intracerebral and Subarachnoid Hemorrhage Research
- Brain Metastases and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Pituitary Gland Disorders and Treatments
- Vascular Malformations Diagnosis and Treatment
- Neurological Complications and Syndromes
- Cerebral Venous Sinus Thrombosis
- Amoebic Infections and Treatments
- Bone and Joint Diseases
- Head and Neck Surgical Oncology
- Fetal and Pediatric Neurological Disorders
- Bone health and treatments
- Pain Management and Opioid Use
- COVID-19 and healthcare impacts
- Acute Kidney Injury Research
- Spine and Intervertebral Disc Pathology
- Acute Ischemic Stroke Management
University Hospital Bonn
2021-2025
Spinal dorsal instrumentation (SDI) is an established treatment for degenerative spinal diseases. Adequate and immediate postoperative pain control important patient recovery may be compromised by uncertainty about its efficacy concern early surgical complications or adverse events. The aim of the current study was to compare use epidural analgesia (EA) with systemic (SA) as regards reduction after SDI. Pain management in patients undergoing SDI posterior approach between January 2019 July...
Abstract Background Poor-grade aneurysmal subarachnoid hemorrhage (SAH) is associated with poor neurological outcome and high mortality. A major factor influencing morbidity mortality brain swelling in the acute phase. Decompressive craniectomy (DC) currently used as an option order to reduce intractably elevated intracranial pressure (ICP). However, execution optimal timing of DC remain unclear. Methods PICASSO resembles a multicentric, prospective, 1:1 randomized standard...
Abstract Introduction Bone mineral density (BMD) plays a crucial role in diagnosing and treating various systemic chronic diseases. Patients with multiple or singular spinal metastasis (SM) are typically advanced stages of cancer, often leading to significant alterations BMD. The present study investigated the prognostic value perioperative Hounsfield units (HU) as surrogate independent marker for estimated BMD patients SM after surgical treatment (ST). Methods HU values, serving BMD, were...
Emerging evidence emphasizes the prognostic importance of meningioma location. The present investigation evaluates whether progression-free survival (PFS), proliferative potential, World Health Organization (WHO) grades, and inflammatory burden differ between anatomical locations (skull base, non-skull spinal) meningiomas. Five-hundred-forty-one patients underwent Simpson grade I or II resection for WHO 1 2 Univariable analysis revealed that spinal are significantly older, had a worse...
Rationale: Aneurysmal subarachnoid hemorrhage (SAH) has high morbidity and mortality. While the primary injury results from initial bleeding cannot currently be influenced, secondary through vasospasm delayed cerebral ischemia worsens outcome might a target for interventions to improve outcome. To date, beside aneurysm treatment prevent re-bleeding administration of oral nimodipine, there is no therapy available, so novel concepts are needed. Evidence suggests that inflammation contributes...
The best time for cranioplasty (CP) after decompressive craniectomy (DC) is controversial, and there are no authoritative guidelines yet. Both complications as well outcome may depend on the timing of CP. aim this single-center study was to evaluate impact late CP procedural safety patient outcome.
The MIB-1 index is an essential predictor of progression-free-survival (PFS) in meningioma. To date, the not available preoperative treatment planning. A score estimating patients with intracranial meningiomas has been investigated so far. Between 2013 and 2019, 208 tumor morphology data, plasma fibrinogen serum C-reactive protein (CRP) data underwent surgery for WHO grade I II An optimal cut-off value (≥6/<6) prediction recurrence was determined by ROC curve analysis (AUC: 0.71; 95% CI:...
Delayed cerebral ischemia (DCI) is a predictor of poor outcome after aneurysmal subarachnoid hemorrhage (SAH). Treatment strategies vary and include induced hypertension invasive endovascular treatment. After the IMCVS trial (NCT01400360), which failed to demonstrate benefit treatment for vasospasm (CVS) resulted in significantly worse outcome, we changed our policy patients with diagnosed CVS only, present prospective results subgroup SAH meeting inclusion criteria trial. All underwent...
Acute kidney injury (AKI) is a known predictor of unfavorable outcome in patients treated at the ICU, irrespective disease. However, data on potential influence serum creatinine (sCr) hospital admission suffering from aneurysmal subarachnoid hemorrhage (SAH) scarce. A total 369 consecutive SAH were included this retrospective cohort study. Patients divided into good-grade (WFNS I−III) versus poor-grade IV−V). Outcome was assessed according to modified Rankin Scale (mRS) after 6 months and...
Surgical treatment of intracranial aneurysm requires advanced technologies to achieve optimal results. Recently, rapid ventricular pacing (RVP) has been described be an elegant technique that facilitates clip reconstruction complex unruptured (uIA). However, there is also a growing need for intraoperative tools ensure safe ruptured (rIA). We conducted retrospective analysis 17 patients who underwent RVP during surgical aneurysms. Nine had uIA while eight surgery rIA suffering from...
Abstract Purpose Patients with spinal metastases (SM) from solid neoplasms typically exhibit progression to an advanced cancer stage. Such can either develop concurrently existing diagnosis (termed metachronous SM) or emerge as the initial indication of undiagnosed malignancy (referred synchronous SM). The present study investigates prognostic implications compared SM following surgical resection. Methods From 2015 2020, a total 211 individuals underwent intervention for at our...
Chronic subdural hematoma (cSDH) is a common disease in the neurological and neurosurgical world. The recommended treatment for cSDH patients with moderate or severe symptoms surgical evacuation, but frequently recurs. patient's ABO blood type may influence outcome. This study aims to evaluate correlation between recurrence O. We performed retrospective analysis of data who were surgically treated. Recurrence was defined as need re-operation within first 12 weeks after initial surgery....
Recent studies have demonstrated emerging evidence of the role inflammation in growth and recurrence chronic subdural hematoma (cSDH). Red blood cell distribution width to platelet count ratio (RPR) is a novel biomarker for cancer, cardiac, inflammatory diseases. The present retrospective study investigated impact RPR on after burr hole surgery cSDH 297 patients.The optimal cut-off value was defined as ≥0.0568 according receiver operating characteristic curve (AUC:0.64, 95%CI:0.55-0.72, p =...
A non-convulsive status epilepticus (ncSE) is a potentially fatal complication for patients in neurointensive care. In with aneurysmal subarachnoid hemorrhage (SAH), ncSE remains scarcely investigated. this study, we aim to investigate the frequency and influence of on outcome SAH. We retrospectively analyzed data consecutive evaluated clinical, radiological, demographical electroencephalogram (EEG) data. Outcome was assessed according modified Rankin Scale (mRS) at 6 months stratified into...
More than 50% of atypical meningiomas regrow within 5 years after surgery. FORGE score is a newly created tool to estimate the MIB-1 index in cranial meningiomas. In this investigation, we aimed assess predictive value combination with major diagnostic criteria meningioma (brain invasion, mitotic count ≥ 4) regarding recurrence We included patients operated on primary our center from 2011 2019. The study 71 (58% women, median age 63 years). ROC curves revealed superiority combined...
The MIB-1 index was demonstrated to be significantly correlated meningioma recurrence. However, date, the relationship of intraindividual course and growth fraction, respectively, clinical tumor recurrence has not been in cranial WHO grade 1 2 meningiomas. In present paper, we compare indices 16 solely surgically treated primary meningiomas their recurrent tumors regarding indices, time recurrence, reproducibility factors influencing indices. Regression analyses revealed (1) a strong...
The aim was to evaluate hospitalization rates for aneurysmal subarachnoid hemorrhage (SAH) within an interdisciplinary multicenter neurovascular network (NVN) during the shutdown COVID-19 pandemic along with its modifiable risk factors. In this study, admission SAH were compared period of in Germany (calendar weeks (cw) 12 16, 2020), periods before (cw 6-11) and after 17-21 22-26, as well corresponding cw years 2015-2019. Data on all-cause pre-hospital mortality area NVN retrieved from...
Abstract Study design Retrospective single center cohort study. Purpose Spinal instrumentation in combination with antibiotic therapy is a treatment option for acute or chronic pyogenic spondylodiscitis (PSD). This study compares the early fusion outcome multi-level and single-level PSD after urgent surgical interbody fixation. Methods retrospective Over 10 year period at institution, all surgically treated patients received debridement, und fixation of spine to treat PSD. Multi-level cases...
Cerebrospinal fluid (CSF) metabolites are increasingly recognized as prognostic factors in aneurysmal subarachnoid hemorrhage (SAH). The CSF arginine/ornithine ratio (Arg/Orn) was shown to predict cerebral vasospasms and clinical outcome SAH. additive value of Arg/Orn over established scores has not been investigated. the SAH, FRESH, SAH-PDS, HAIR, Rosen–McDonald, Hunt Hess, WFNS modified Fisher scale were determined a prospective cohort patients with Logistic regression models favorable...
Abstract Purpose Patients with spinal metastases (SM) from solid neoplasms typically exhibit progression to an advanced cancer stage. Such can either develop concurrently existing diagnosis (termed metachronous SM) or emerge as the initial indication of undiagnosed malignancy (referred synchronous SM). The present study investigates prognostic implications compared SM following surgical resection. Methods From 2015 2020, a total 211 individuals underwent intervention for at our...
MIB-1 index is an important predictor of meningioma progression. However, not available in the preoperative tailored medical decision-making process. A scoring sheet independently estimating indices spinal (SM) patients has been investigated so far.Between 2000 and 2020, 128 with clinical data, tumor imaging inflammatory laboratory (plasma fibrinogen, serum C-reactive protein) neuropathological reports (MIB-1, mitotic count, CD68 staining) underwent surgery for WHO grade 1 2 meningioma.An...
Although meningiomas are mainly non-aggressive and slow-growing tumors, there is a remarkable recurrence rate in long-term follow-up. Proliferative activity progression-free survival (PFS) differs significantly among the anatomic location of meningiomas. The aim present study was to investigate predictive power MIB-1 labeling index mitotic count (MC) regarding probability PFS subgroup skull-base A total 145 patients were included this retrospective study. Histopathological examinations...
Introduction: The aim of the study was to analyze risk factors for hematoma expansion (HE) in patients undergoing decompressive hemicraniectomy (DC) with elevated intracranial pressure due spontaneous intracerebral (ICH). Methods: We retrospectively evaluated 72 ICH who underwent DC at our institution. compared pre- and postoperative volumes divided into two groups: first, HE > 6 cm3 (group 1), second, without 2). Additionally, we screened medical history anticoagulant antiplatelet...
Abducens nerve palsy is a severe dysfunction after petroclival meningioma (PC MNG) surgery. The objective of this investigation was to analyze abducens outcomes in patients who underwent the retrosigmoid approach relation MIB-1 index. Thirty-two with primary sporadic PC MNG were retrospectively analyzed. Mean follow-up 28.0 months. Analysis index performed evaluate outcome. An optimal cut-off value (<4/≥4) association postoperative CN VI determined by ROC analysis (AUC: 0.74, 95% CI:...