A5000136988- Meningioma and schwannoma management
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Neurofibromatosis and Schwannoma Cases
- Glioma Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Head and Neck Surgical Oncology
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrospinal fluid and hydrocephalus
- Pituitary Gland Disorders and Treatments
- Vascular Malformations Diagnosis and Treatment
- Spinal Fractures and Fixation Techniques
- Acute Ischemic Stroke Management
- Cerebral Venous Sinus Thrombosis
- Epilepsy research and treatment
- Brain Metastases and Treatment
- Ear and Head Tumors
- Pharmacological Effects and Toxicity Studies
- Peripheral Nerve Disorders
- Neurological Complications and Syndromes
- Pain Management and Treatment
- Facial Nerve Paralysis Treatment and Research
- Management of metastatic bone disease
- Migraine and Headache Studies
- Transcranial Magnetic Stimulation Studies
University Hospital Leipzig
2023-2025
University Hospital Bonn
2015-2023
University of Bonn
2015-2020
Abstract To assess the predictive accuracy of advanced AI language models and established clinical scales in prognosticating outcomes for patients with aneurysmal subarachnoid hemorrhage (aSAH). This retrospective cohort study included 82 suffering from aSAH. We evaluated efficacy AtlasGPT ChatGPT 4.0 by examining area under curve (AUC), sensitivity, specificity, Youden’s Index, comparison to grading such as World Federation Neurological Surgeons (WFNS) scale, Simplified Endovascular Brain...
Cerebral venous sinus thrombosis (CVST) is a known complication of posterior fossa surgery near the sigmoid and transverse sinus. The incidence treatment postoperative asymptomatic CVST are controversial.To analyze incidence, risk factors, management after tumor surgery.In this retrospective, single-center study, we included all patients who underwent in semisitting position between January 2013 December 2020. All preoperative imaging using MRI with/without additional computed tomography...
Background: Although the initial functional outcome findings of International Subarachnoid Aneurysm Trial (ISAT) study favored coiling at one year after aneurysmal subarachnoid hemorrhage (aSAH), concerns arose regarding limited long-term rerupture data. This meta-analysis is first to analyze longitudinal individual patient data (IPD) target aneurysm in terms treatment modality. Methods: The present included studies that compared clipping with ruptured aneurysms rerupture. Rerupture rates'...
Both pre- and postoperative seizures comprise common side effects that negatively impact patient quality of life in those suffering from intracranial meningioma. Therefore, seizure freedom represents an important outcome measure meningioma surgery. In the current study authors analyzed their institutional database to identify risk factors for occurrence after surgical therapy patients with preoperative symptomatic epilepsy.
Abstract Background Acute subdural hematoma is a critical condition, leading to significant morbidity and mortality. Despite advancements in surgical techniques, portion of patients only show limited clinical improvement post-evacuation. Surgical intervention decisions are critically important, as they can either improve or worsen patient’s condition. Radiomics offers potential by extracting complex patterns from digital medical images transforming them into high-dimensional data that...
To investigate the release of proinflammatory damage-associated molecular pattern molecule "high-mobility group box-1" in serum patients after aneurysmal subarachnoid hemorrhage and its association with cerebral vasospasm.Retrospective observational study.University hospital.Aneurysmal admitted within 24 hours ictus.Standard treatment clipping or coiling aneurysm.We enrolled 53 from which peripheral venous blood was withdrawn on days 1, 3, 5, 7, 9, 11, 13 once controls to obtain serum. Serum...
Gap junctions have recently been shown to interconnect glioblastoma cells a multicellular syncytial network, thereby allowing intercellular communication over long distances as well enabling form routes for brain microinvasion. Against this backdrop gap junction-targeted therapies might provide an essential contribution isolate cancer within the brain, thus increasing tumor cells' vulnerability standard chemotherapeutic agent temozolomide. By utilizing INI-0602-a novel junction inhibitor...
OBJECTIVE Cavernoma-related epilepsy (CRE) is a frequent symptom in patients with cerebral cavernous malformations (CCMs). Reports on surgical management and seizure outcome of epileptogenic CCM often focus intracranial cavernoma general. Therefore, data CCMs within the temporal lobe are scarce. The authors therefore analyzed their institutional data. METHODS From 2003 to 2018, 52 suffering from located underwent surgery for CRE at University Hospital Bonn. Information patient...
Emerging evidence emphasizes the prognostic importance of meningioma location. The present investigation evaluates whether progression-free survival (PFS), proliferative potential, World Health Organization (WHO) grades, and inflammatory burden differ between anatomical locations (skull base, non-skull spinal) meningiomas. Five-hundred-forty-one patients underwent Simpson grade I or II resection for WHO 1 2 Univariable analysis revealed that spinal are significantly older, had a worse...
Objective: The present study investigates a score based on baseline C-reactive protein (CRP) and fibrinogen values (FC score) in 173 consecutive glioblastoma (GBM) patients. Methods: optimal cut-off value for CRP was defined as 3.5 g/dl 3.0 mg/L, respectively, according to previous reports. Patients with elevated were classified of 2, those an elevation only one these parameters allocated 1, without any abnormalities assigned 0. Results: No significant differences age, gender, tumor area,...
Background Occipital nerve stimulation (ONS) has been reported to diminish pain levels in intractable chronic headache syndromes of different origin. No reliable objective markers exist predict ONS responsiveness. This study investigated the predictive value occipital percutaneous field (PENS) prior ONS. Methods trial included 12 patients (CCH, CM, PTH, CH) with refractory eligible for Repetitive PENS (3 × /10 days) was performed and severity/frequency monitored over four weeks before...
Abstract Background Facial nerve palsy is a severe morbid condition that occurs after vestibular schwannoma (VS) surgery. The objective of this study was to evaluate facial outcomes based on surgical techniques, tumour size, and immunohistochemical factors. Methods One hundred eighteen patients with VS were retrospectively analysed. Gross total resection (GTR) achieved in 83 patients, subtotal (STR) 35 patients. Follow-up 60 months (median). assessed for 24 Analysis the MIB-1 index performed...
Objective: Tumor-associated proptosis comprises a frequent phenomenon that negatively impacts quality of life in patients suffering from spheno-orbital meningioma (SOM). Therefore, outcome represents an important measure surgery. In the current study, we analyzed our institutional database order to evaluate recovery tumor-associated with SOM. Methods: Between 2009 and 2019, 32 SOM underwent surgical treatment at authors' institution. The exophthalmos index (EI) was calculated by means...