A5023744824- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Vascular Malformations Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Cardiovascular Health and Disease Prevention
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological Disease Mechanisms and Treatments
- Cerebral Venous Sinus Thrombosis
- Cerebrovascular and genetic disorders
- Peripheral Artery Disease Management
- Spinal Fractures and Fixation Techniques
- Neurological Disorders and Treatments
- Neurosurgical Procedures and Complications
- Meningioma and schwannoma management
- RNA regulation and disease
- Stroke Rehabilitation and Recovery
- MRI in cancer diagnosis
- Cerebrospinal fluid and hydrocephalus
- Moyamoya disease diagnosis and treatment
- Cardiac Imaging and Diagnostics
- Bone and Joint Diseases
- Neonatal and fetal brain pathology
University Hospital Heidelberg
2002-2021
Heidelberg University
1980-2021
Universität Hamburg
2003-2015
University Medical Center Hamburg-Eppendorf
2002-2015
University Hospital Münster
2006-2010
Medizinische Hochschule Hannover
2010
University of Münster
2010
Kiel University
2010
Klinik und Poliklinik für Neurologie
2003-2006
Boehringer Ingelheim (Germany)
2006
In this retrospective analysis we report our treatment experience in 65 consecutive patients with clinical signs of severe brainstem ischemia angiographically demonstrated thrombotic vertebrobasilar artery occlusions who received either local intra-arterial thrombolytic therapy (urokinase or streptokinase) (43 patients) conventional (antiplatelet agents anticoagulants) (22 patients). We analyzed the data respect to cerebral occlusion patterns, posttreatment arterial recanalization, and...
The possibility that intra-arterial local infusion of fibrinolytic agents may achieve recanalization previously occluded carotid territory arteries in acute stroke was tested a prospective angiography-based open pilot study at two centers. Fifteen 20 patients with symptoms (mean treatment-onset interval 7.6 hours) demonstrated complete recanalization; 10 the 15 exhibited clinical improvement varying degree by time hospital discharge. Four suffered hemorrhagic transformation infarcted without...
Background and Purpose— The goals of this study were to examine MRI baseline characteristics patients with acute ischemic stroke (AIS) the influence intravenous tissue plasminogen activator (tPA) on MR parameters functional outcome using a multicenter approach. Methods— In open-label, nonrandomized AIS suspected anterior circulation stroke, subjects received multiparametric protocol (diffusion- perfusion-weighted imaging angiography) within 6 hours after symptom onset follow-up. Patients...
Background and Purpose — A mismatch between diffusion- perfusion-weighted MRI is thought to define tissue at risk of infarction. This concept based on the assumption that diffusion slowing decreases in apparent coefficient (ADC) serve as indicator proceeding We tested this hypothesis. Methods (diffusion weighted, perfusion MRA, T2 weighted) was performed 15 patients with acute stroke within 2.9±0.8 hours (mean±SD) onset days 1 7. After intraindividual realignment ADC maps, development range...
Background and Purpose— We compared outcome symptomatic bleeding complications of intravenous tissue plasminogen activator (IV-tPA) within 6 hours symptom onset in MRI-selected patients with acute middle cerebral artery infarction the pooled data large stroke tPA trials. Methods— Patients were examined by perfusion-weighted diffusion-weighted imaging ≤6 hours. Within 3 hours, treated according to Second European-Australasian Acute Stroke Study (ECASS II) criteria. After treatment IV-tPA was...
In order to relate clinical, angiologic and brain-morphological findings, 107 patients with internal carotid artery occlusion were examined clinically by Doppler sonography, computerized tomography cerebral angiography. During tomography, haemodynamically induced infarctions could be differentiated from those, caused periocclusive embolism towards the major brain arteries. This differentiation was based on an integration of angiological as well data implicates some important diagnostic,...
Background and Purpose— We sought to describe the frequency of normalization apparent diffusion coefficient (ADC) values that are decreased in hyperacute stroke identify characteristics tissue demonstrating normalization. Methods— Sixty-eight acute ischemic patients underwent MRI examination (including diffusion/perfusion imaging MR angiography) within 6 hours (mean, 2.8 hours) after symptom onset, 24 hours, again 4 7 days later. Lesion volumes with ADC delayed time peak perfusion were...
We tested the hypothesis that early diffusion- and perfusion-weighted MRI (DWI PWI, respectively) allows prediction of malignant middle cerebral artery (MCA) infarction (MMI).Thirty-seven patients with acute MCA proximal vessel occlusion (carotid-T, main stem) were studied by DWI, MR angiography within 6 hours symptom onset. Eleven developed MMI, defined decline consciousness radiological signs space-occupying brain edema. Lesion volumes retrospectively as apparent diffusion coefficient <80%...
Background and Purpose— A combined therapy of local recombinant tissue plasminogen activator (rtPA) fibrinolysis intravenous Abciximab platelet inhibition with additional percutaneous transluminal angioplasty (PTA)/stenting may improve recanalization neurological outcome in patients acute vertebrobasilar occlusion. MethodsCombined FAST consisted on bolus (0.25 mg/kg) followed by a 12-hour infusion (0.125 μg/kg per minute) low-dose intra-arterial rtPA (median dosage: 20 mg, cohort: N=47). The...
The purpose of this study was to analyze angiographic and clinical results before after additional endovascular therapy in patients with previously coiled but reopened cerebral aneurysms identify possible risk factors for retreatment an aneurysm.Follow-up selective digital subtraction angiography performed 323/596 (54.2%) harboring 342 a mean follow-up time 28.6 months. were divided into 3 groups: group A, who remained stable initial treatment; B, showed minor morphologic changes; C,...
Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
Background Treatment of individuals with asymptomatic carotid artery stenosis is still handled controversially. Recommendations for treatment endarterectomy (CEA) are based on trials having recruited patients more than 15 years ago. Registry data indicate that advances in best medical (BMT) may lead to a markedly decreasing risk stroke stenosis. The aim the SPACE-2 trial (ISRCTN78592017) was compare preventive effects BMT alone combination CEA or stenting (CAS), respectively, ≥70% European...
Purpose: To prospectively evaluate whether diffusion-tensor magnetic resonance (MR) imaging depicts differences in World Health Organization (WHO) grade II and III glial brain tumors on the basis of tumor architecture peritumoral tract invasion. Materials Methods: The study protocol was approved by local ethics committee, written informed consent obtained. Diffusion-tensor MR performed 23 patients (15 men, eight women; mean age, 47 years) with histologically confirmed gliomas. Eleven were...
In view of the poor prognosis for patients with acute intracranial vertebrobasilar occlusion (VBO), factors were sought that predict survival and good neurologic outcome after endovascular treatment by means local intra-arterial fibrinolysis (LIF) percutaneous transluminal angioplasty (PTA). LIF was performed in 83 angiographically established VBO. A significant residual stenosis treated additional PTA 8 patients. The types classified as either embolic (EO) or atherothrombotic (AO). Outcome...