A5102777330- Nitric Oxide and Endothelin Effects
- Peripheral Artery Disease Management
- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Metabolism and Genetic Disorders
- Eicosanoids and Hypertension Pharmacology
- Cancer, Hypoxia, and Metabolism
- Cardiac, Anesthesia and Surgical Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Lipoproteins and Cardiovascular Health
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Health and Disease Prevention
- Vascular Procedures and Complications
- Renin-Angiotensin System Studies
- Cardiac Valve Diseases and Treatments
- Amino Acid Enzymes and Metabolism
- Cancer-related gene regulation
- Cardiovascular Issues in Pregnancy
- Antiplatelet Therapy and Cardiovascular Diseases
- Pulmonary Hypertension Research and Treatments
- Adenosine and Purinergic Signaling
- Medical Practices and Rehabilitation
- Cardiac Arrhythmias and Treatments
- Genomics and Phylogenetic Studies
Technische Universität Dresden
2015-2024
University Hospital Carl Gustav Carus
2015-2024
Klinik und Poliklinik für Psychotherapie und Psychosomatik
2010-2021
Center for Vascular Biology Research
2014
Leibniz Institute DSMZ – German Collection of Microorganisms and Cell Cultures
1984-2003
Cardiovascular Institute of the South
2002
Boston University
2001
Ludwig-Maximilians-Universität München
1999
München Klinik
1995
Homocyst(e)ine (Hcy) inhibits the expression of antioxidant enzyme cellular glutathione peroxidase (GPx-1) in vitro and vivo , which can lead to an increase reactive oxygen species that inactivate NO promote endothelial dysfunction. In this study, we tested hypothesis overexpression GPx-1 restore normal phenotype hyperhomocyst(e)inemic states. Heterozygous cystathionine β-synthase-deficient (CBS (−/+) ) mice their wild-type littermates (+/+) were crossbred with overexpress [GPx-1 (tg+)...
Cellular glutathione peroxidase (GPx-1) is the most abundant intracellular isoform of GPx antioxidant enzyme family. In this study, we hypothesized that GPx-1 deficiency directly induces an increase in vascular oxidant stress, with resulting endothelial dysfunction. We studied function a murine model homozygous (GPx-1 −/− ). Mesenteric arterioles mice demonstrated paradoxical vasoconstriction to β-methacholine and bradykinin, whereas wild-type (WT) showed dose-dependent vasodilation response...
Worldwide, rivaroxaban is increasingly used for stroke prevention in atrial fibrillation (SPAF) but little known about the rates of or reasons discontinuations daily care. Using data from a prospective, non-interventional oral anticoagulation (NOAC) registry, we analysed treatment persistence. Persistence with SPAF was assessed an ongoing, registry >2600 NOAC patients care using Kaplan–Meier time-to-first-event analysis. Reasons and management discontinuation were assessed. Potential...
A collection of 47 strains obligately anaerobic, gram-negative, rod-shaped bacteria that were isolated mainly from spoiled beer and pitching yeast was studied to learn more about their taxonomic positions. new species the genus Pectinatus, Pectinatus frisingensis, a Selenomonas, Selenomonas lacticifex, comprising two species, Zymophilus raffinosivorans paucivorans, are described. All contained directly cross-linked meso-diaminopimelic acid-containing peptidoglycan in addition diamine...
Abstract Aims Drug-coated balloons (DCBs) for femoropopliteal interventions have not been tested against each other. We aimed to directly compare efficacy and safety of a high-dose (In.Pact™) vs. low-dose (Ranger™) DCB with nominal paclitaxel densities 3.5 2.0 μg/mm2. Methods results Within prospective, multicentre, non-inferiority, clinical trial 414 patients symptomatic lesions (Rutherford classification 2–4) were randomly assigned in 1:1 ratio endovascular treatment either high- or after...
Abstract Background Revascularization is the primary treatment modality for chronic limb-threatening ischaemia (CLTI), but not feasible in all patients. PLX-PAD an off-the-shelf, placental-derived, mesenchymal stromal cell-like cell therapy. This study aimed to evaluate whether would increase amputation-free survival people with CLTI who were candidates revascularization. Methods People and minor tissue loss (Rutherford 5) unsuitable revascularization entered into a randomized,...
Vitamin-K antagonists (VKA) and non-vitamin-K dependent oral anticoagulants (NOAC) have been approved for anticoagulation in venous thromboembolism (VTE) atrial fibrillation patients previously treated with VKA are switched to NOAC therapy. Safety data this switching urgently needed.Using from a large regional prospective registry of daily care patients, we evaluated the safety dabigatran or rivaroxaban. Switching procedures cardiovascular bleeding events occurring within 30 days after were...
Abstract Dimethylarginine dimethylaminohydrolase 1 (DDAH1) protects against cardiovascular disease by metabolising the risk factor asymmetric dimethylarginine (ADMA). However, question whether second DDAH isoform, DDAH2, directly metabolises ADMA has remained unanswered. Consequently, it is still unclear if DDAH2 may be a potential target for ADMA-lowering therapies or drug development efforts should focus on DDAH2’s known physiological functions in mitochondrial fission, angiogenesis,...
In a previous study the authors reported characterization of some facultatively anaerobic, Gram-positive, non-sporeforming rods which were found in mixed cultures from various infectious processes, including patients with otitis, empyema, perianal abscesses and decubitus ulcers. Phenotypically these organisms closely resembled Actinomyces pyogenes although their precise taxonomic position remained unknown. present investigation have determined 16S rRNA gene sequences representative strains...
Percutaneous devices for creation of native arteriovenous fistulae offer an alternative to traditional open surgical techniques. The 4F WavelinQ EndoAVF System was developed as a lower profile facilitate access through smaller vessels and minimize site complications; current report is the original first experience this device, assessing outcome in 120 patients followed 6 months.The use system three studies, EASE (32 patients), EASE-2 (24 EU postmarket clinical follow-up study (64 patients)...
Background Homoarginine ( hA rg) has been shown to be cardioprotective in a model of ischemic heart failure; however, the mechanism remains unknown. rg can inhibit tissue-nonspecific alkaline phosphatase TNAP ), an enzyme that promotes vascular calcification. We hypothesized will exert beneficial effects by reducing calcification mouse coronary artery disease associated with overexpression and hypercholesterolemia. Methods Results was overexpressed endothelium mice homozygous for low-density...
Abstract Low plasma concentrations of L-homoarginine are associated with an increased risk cardiovascular events, while homoarginine supplementation is protective in animal models metabolic syndrome and stroke. Catabolism still poorly understood. Based on the recent findings from a Genome Wide Association Study we hypothesized that can be metabolized by alanine:glyoxylate aminotransferase 2 (AGXT2). We purified human AGXT2 tissues transgenic mice demonstrated its ability to metabolize...
5-Lipoxygenase (5-LO) and its downstream leukotriene products have been implicated in the development of pulmonary hypertension. In this study, we examined effects 5-LO overexpression rat lungs on hypertension using a recombinant adenovirus expressing (Ad5-LO). Transthoracic echocardiography right heart catheterization data showed that lung did not cause normal rats; however, it markedly accelerated progression rats treated with monocrotaline (MCT). An increase artery pressure occurred...