A5086027330- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrospinal fluid and hydrocephalus
- Optical Imaging and Spectroscopy Techniques
- Neurosurgical Procedures and Complications
- Traumatic Brain Injury Research
- Cardiac Arrest and Resuscitation
- S100 Proteins and Annexins
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Intracranial Aneurysms: Treatment and Complications
- Acute Ischemic Stroke Management
- Fetal and Pediatric Neurological Disorders
- Hemodynamic Monitoring and Therapy
- Trauma and Emergency Care Studies
- Cerebral Venous Sinus Thrombosis
- Sepsis Diagnosis and Treatment
- Neonatal and fetal brain pathology
- Non-Invasive Vital Sign Monitoring
- Heart Rate Variability and Autonomic Control
- Advanced MRI Techniques and Applications
- Radiation Dose and Imaging
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiac, Anesthesia and Surgical Outcomes
- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
University of Cambridge
2016-2025
Warsaw University of Technology
2016-2025
Addenbrooke's Hospital
2016-2025
Cambridge University Hospitals NHS Foundation Trust
2009-2025
Universidade Nove de Julho
2023
Université de Picardie Jules Verne
2023
Universidade de São Paulo
2023
Charles University
2023
Military University Hospital Prague
2023
University of Groningen
2012-2022
The effect of decompressive craniectomy on clinical outcomes in patients with refractory traumatic intracranial hypertension remains unclear.
OBJECTIVE: Cerebrovascular vasomotor reactivity reflects changes in smooth muscle tone the arterial wall response to transmural pressure or concentration of carbon dioxide blood. We investigated whether slow waves blood (ABP) and intracranial (ICP) may be used derive an index that vessels ABP. METHODS: A method for continuous monitoring association between spontaneous ICP was adopted a group 82 patients with head injuries. ABP, ICP, transcranial doppler flow velocity middle cerebral artery...
Objectives To define optimal cerebral perfusion pressure (CPPOPT) in individual head-injured patients using continuous monitoring of cerebrovascular reactivity. test the hypothesis that with poor outcome were managed at a (CPP) differing more from their CPPOPT than good outcome. Design Retrospective analysis prospectively collected data. Setting Neurosciences critical care unit university hospital. Patients A total 114 admitted between January 1997 and August 2000 mean arterial blood (MAP)...
Objectives: We have sought to develop an automated methodology for the continuous updating of optimal cerebral perfusion pressure (CPPopt) patients after severe traumatic head injury, using monitoring cerebrovascular reactivity. then validated CPPopt algorithm by determining association between outcome and deviation actual CPP from CPPopt. Design: Retrospective analysis prospectively collected data. Setting: Neurosciences critical care unit a university hospital. Patients: A total 327...
Background and Purpose— Statins may improve cerebral vasomotor reactivity through cholesterol-dependent -independent mechanisms. A phase II randomized controlled trial was conducted to examine the hypothesis that acute pravastatin treatment could cerebrovascular autoregulation reduce vasospasm-related complications after aneurysmal subarachnoid hemorrhage (SAH). Methods— total of 80 SAH (aSAH) patients (18 84 years age) within 72 hours from ictus were equally receive either oral (40 mg) or...
Background and Purpose Disturbed cerebral autoregulation has been reported to correlate with an unfavorable outcome after head injury. Using transcranial Doppler ultrasonography, we investigated whether hemodynamic responses spontaneous variations of perfusion pressure (CPP) provide reliable information on autoregulatory reserve. Methods We studied 82 patients injury daily. Waveforms intracranial (ICP), arterial pressure, flow velocity (FV) were captured during 2-hour periods. Time-averaged...
Secondary insults can adversely influence outcome following severe traumatic brain injury. Monitoring of cerebral extracellular chemistry with microdialysis has the potential for early detection metabolic derangements associated such events. The objective this study was to determine relationship between fundamental biochemical markers and neurological in a large cohort patients Prospectively collected observational neuromonitoring data from 223 were analysed. modalities included digitally...
Background and Purpose— Assessment of autoregulation in the time domain is a promising monitoring method for actively optimizating cerebral perfusion pressure (CPP) critically ill patients. The ability to detect loss autoregulatory vasoreactivity spontaneous fluctuations CPP was tested with new time-domain that used near-infrared spectroscopic measurements tissue oxyhemoglobin saturation an infant animal model. Methods— Piglets were made progressively hypotensive over 4 5 hours by inflation...
Background and Purpose— Individualizing mean arterial blood pressure targets to a patient’s cerebral flow autoregulatory range might prevent brain ischemia for patients undergoing cardiopulmonary bypass (CPB). This study compares the accuracy of real-time autoregulation monitoring using near-infrared spectroscopy with that transcranial Doppler. Methods— Sixty adult CPB had Doppler middle artery velocity monitoring. The index (Mx) was calculated as moving, linear correlation coefficient...
Microdialysis enables the chemistry of extracellular interstitial space to be monitored. Use this technique in patients with acute brain injury has increased our understanding pathophysiology several neurological disorders. In 2004, a consensus document on clinical application cerebral microdialysis was published. Since then, there have been significant advances use neurocritical care. The objective review is report International Forum held Cambridge, UK, April 2014 and produce revised...
Delayed cerebral ischemia (DCI) is a recognized contributor to unfavorable outcome after subarachnoid hemorrhage (SAH). Recent data challenge the concept of vasospasm as sole cause and suggest multifactorial process with dysfunctional autoregulation component. We tested hypothesis that early autoregulatory failure, detected using near-infrared spectroscopy-based index, TOxa transcranial Doppler-based Sxa, can predict DCI.In this prospective observational study we enrolled consecutive...
Background The invasive nature of the current methods for monitoring intracranial pressure (ICP) has prevented their use in many clinical situations. Several attempts have been made to develop monitor ICP non-invasively. aim this study is assess relationship between ultrasound-based non-invasive (nICP) and measurement neurocritical care patients. Methods findings This was a prospective, single-cohort observational patients admitted tertiary unit. Patients with brain injury requiring were...