Karol P. Budohoski

ORCID: 0000-0003-2866-1380
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About
Contact & Profiles
Research Areas
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Intracranial Aneurysms: Treatment and Complications
  • Cerebrovascular and Carotid Artery Diseases
  • Meningioma and schwannoma management
  • Acute Ischemic Stroke Management
  • Neurosurgical Procedures and Complications
  • Cerebrospinal fluid and hydrocephalus
  • Vascular Malformations Diagnosis and Treatment
  • Neurofibromatosis and Schwannoma Cases
  • Head and Neck Surgical Oncology
  • Pituitary Gland Disorders and Treatments
  • Optical Imaging and Spectroscopy Techniques
  • Moyamoya disease diagnosis and treatment
  • Glioma Diagnosis and Treatment
  • Cardiac Arrest and Resuscitation
  • Spinal Fractures and Fixation Techniques
  • Trigeminal Neuralgia and Treatments
  • S100 Proteins and Annexins
  • Cardiovascular Health and Disease Prevention
  • Cerebral Venous Sinus Thrombosis
  • Traumatic Brain Injury Research
  • Stroke Rehabilitation and Recovery
  • Trauma and Emergency Care Studies
  • Venous Thromboembolism Diagnosis and Management
  • Spine and Intervertebral Disc Pathology

University of Utah
2021-2025

University of Cambridge
2015-2024

Addenbrooke's Hospital
2014-2024

University of Utah Health Care
2024

Cambridge University Hospitals NHS Foundation Trust
2015-2023

University of California, San Francisco
2021-2022

National Institute for Health Research
2020-2022

Neurological Surgery
2021

Stony Brook University
2021

Shinshu University
2021

Objectives: We have sought to develop an automated methodology for the continuous updating of optimal cerebral perfusion pressure (CPPopt) patients after severe traumatic head injury, using monitoring cerebrovascular reactivity. then validated CPPopt algorithm by determining association between outcome and deviation actual CPP from CPPopt. Design: Retrospective analysis prospectively collected data. Setting: Neurosciences critical care unit a university hospital. Patients: A total 327...

10.1097/ccm.0b013e3182514eb6 article EN Critical Care Medicine 2012-05-23

Delayed cerebral ischemia (DCI) is a recognized contributor to unfavorable outcome after subarachnoid hemorrhage (SAH). Recent data challenge the concept of vasospasm as sole cause and suggest multifactorial process with dysfunctional autoregulation component. We tested hypothesis that early autoregulatory failure, detected using near-infrared spectroscopy-based index, TOxa transcranial Doppler-based Sxa, can predict DCI.In this prospective observational study we enrolled consecutive...

10.1161/strokeaha.112.669788 article EN Stroke 2012-11-14
David Clark Alexis Joannides Amos O. Adeleye Abdul Hafid Bajamal Tom Bashford and 95 more Hagos Biluts Karol P. Budohoski Ari Ercole Rocío Fernández‐Méndez Anthony Figaji Deepak Gupta Roger Härtl Corrado Iaccarino Tariq Khan Tsegazeab Laeke Andrés M. Rubiano Hamisi K. Shabani Kachinga Sichizya Manoj Kumar Tewari Abenezer Tirsit Myat Thu Manjul Tripathi Rikin Trivedi Bhagavatula Indira Devi Franco Servadei David Menon Angelos G. Kolias Peter J. Hutchinson Ghayur Abbas Omar Ibrahim Abdallah Ahmed Abdel-Lateef Khalif Abdifatah Awfa Abdullateef Ruvini Abeygunaratne Mostafa Aboellil Abass Adam Robert J. Adams Amos O. Adeleye Augustine A. Adeolu Novan Krisno Adji Nur Fitriah Afianti Sudarsan Agarwal Ifeanyi Kene Aghadi Paúl Martín Méndez Aguilar Syeda Rida Ahmad Daniyal Ahmed Nafees Ahmed Haider Aizaz Yunus Kuntawi Aji Alexander Alamri Augusto Jacinto Mussindo Alberto Luis Alcocer Alcocer Lesly Gonzales Alfaro Amro Al-Habib Ahmad Alhourani Syed Muhammad Rafay Ali Fahad Alkherayf Ahmed AlMenabbawy Aliyah Alshareef Muhammad Adil s o Aminullah Madeha Amjad Robson Luís Oliveira de Amorim Sathiaprabhu Anbazhagan Almir Ferreira de Andrade Waleed Antar Theophilus Teddy Kojo Anyomih Salah G. Aoun Tedy Apriawan Daniele Armocida Paul M. Arnold Miguel Ángel Escribano Arráez Temesgen Assefa Gelaw Andres Asser S.P. Athiththan Deepal Attanayake Maung Maung Aung Allan Avi Victor Enrique Antolinez Ayala Mohammed Azab Gaousul Azam Mohd Azharuddin Olukemi Badejo Mohamed Badran Azam Ali Baig Rehman Ali Baig Ankur Bajaj Paul Baker R. Bala Artur Balasa Ross Balchin James A. Balogun Vin Shen Ban Bharath Kumar Reddy Bandi Soham Bandyopadhyay Matthew Bank Ernest J. Barthélemy Mohammed Talha Bashir Luciano Silveira Basso Surajit Basu Auricelio Batista

10.1016/s1474-4422(22)00037-0 article EN The Lancet Neurology 2022-03-16

BACKGROUND: Cerebrovascular pressure reactivity is the principal mechanism of cerebral autoregulation. Assessment autoregulation can be performed by using mean flow index (Mx) based on transcranial Doppler ultrasonography. monitored (PRx), which intracranial monitoring. From a practical point view, PRx continuously, whereas Mx only in short periods when probes applied. OBJECTIVE: To assess to what degree impairment (PRx) associated with (Mx). METHODS: A database 345 patients traumatic brain...

10.1227/neu.0b013e318260feb1 article EN Neurosurgery 2012-05-31

Abstract BACKGROUND Intracranial pressure (ICP) is a clinically important variable after severe traumatic brain injury (TBI) and has been monitored, along with clinical outcome, for over 25 yr in Addenbrooke's hospital, Cambridge, United Kingdom. This time period also seen changes management strategies the implementation of protocolled specialist neurocritical care, expansion neuromonitoring techniques, adjustments treatment targets. OBJECTIVE To describe intracranial monitoring variables...

10.1093/neuros/nyy468 article EN Neurosurgery 2018-09-12

In patients after subarachnoid hemorrhage (SAH) failure of cerebral autoregulation is associated with delayed ischemia (DCI). Various methods assessing are available, but their predictive values remain unknown. We characterize the relationship between different indices autoregulation. Patients SAH within 5 days were included in a prospective study. The three was analyzed: two calculated using spontaneous blood pressure fluctuations, Sxa (based on transcranial Doppler) and TOxa near-infrared...

10.1038/jcbfm.2012.189 article EN Journal of Cerebral Blood Flow & Metabolism 2012-12-12

The impulse response (IR)-based autoregulation index (ARI) allows for continuous monitoring of cerebral using spontaneous fluctuations arterial blood pressure (ABP) and flow velocity (FV). We compared three methods assessment in 288 traumatic brain injury (TBI) patients managed the Neurocritical Care Unit: (1) IR-based ARI; (2) transfer function (TF) phase, gain, coherence; (3) mean (Mx). Autoregulation was calculated TF estimation (Welch method) classified according to original Tiecks’...

10.1038/jcbfm.2014.192 article EN Journal of Cerebral Blood Flow & Metabolism 2014-11-19

Critical closing pressure (CCP) is the arterial blood (ABP) at which brain vessels collapse and cerebral flow (CBF) ceases. Using concept of impedance to CBF, CCP can be expressed with brain-monitoring parameters: perfusion (CPP), ABP, velocity (FV), heart rate. The novel multiparameter method (CCPm) was compared traditional transcranial Doppler (TCD) calculations (CCP1). Digital recordings intracranial (ICP), TCD-based FV from previously published studies 29 New Zealand White rabbits were...

10.1038/jcbfm.2012.161 article EN Journal of Cerebral Blood Flow & Metabolism 2012-11-14

In Brief BACKGROUND: A total hemoglobin reactivity index (THx) derived from near-infrared spectroscopy (NIRS) has recently been introduced to assess cerebrovascular noninvasively. Analogously the pressure (PRx), THx is calculated as correlation coefficient with arterial blood (ABP). However, reliability of in injured brain uncertain. Although slow oscillations have described NIRS signals, their significance for assessment autoregulation remains unclear. current study, we investigated role...

10.1213/ane.0b013e3182285dc0 article EN Anesthesia & Analgesia 2011-08-05

Clinical behaviour of atypical meningiomas is not uniform. While, as a group, they exhibit high recurrence rate, some pursue more benign course, whereas others progress early. We aim to investigate the imaging and pathological factors that predict risk early tumour progression determine whether related outcome. Adult patients with WHO grade II meningioma treated in three regional referral centres between 2007 2014 were included. MRI pathology characteristics assessed. Gross total resection...

10.1007/s00701-018-3593-x article EN cc-by Acta Neurochirurgica 2018-06-30
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