Vincent Degos
A5064997820- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Acute Ischemic Stroke Management
- Traumatic Brain Injury Research
- Vascular Malformations Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Trauma and Emergency Care Studies
- Cholinesterase and Neurodegenerative Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Cerebrospinal fluid and hydrocephalus
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Cardiac Arrest and Resuscitation
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Neonatal and fetal brain pathology
- Anesthesia and Sedative Agents
- Spinal Fractures and Fixation Techniques
- S100 Proteins and Annexins
- Advanced Neuroimaging Techniques and Applications
- Long-Term Effects of COVID-19
- Sepsis Diagnosis and Treatment
Sorbonne Université
2016-2025
Assistance Publique – Hôpitaux de Paris
2015-2025
Pitié-Salpêtrière Hospital
2016-2025
Inserm
2015-2025
Biomarqueurs d’urgence et de réanimation
2018-2025
Université Paris 1 Panthéon-Sorbonne
2019-2025
Centre National de la Recherche Scientifique
2025
Laboratoire d’Imagerie Biomédicale
2025
Université Sorbonne Nouvelle
2019-2024
Sorbonne Paris Cité
2013-2024
Microglia mediate multiple facets of neuroinflammation, including cytotoxicity, repair, regeneration, and immunosuppression due to their ability acquire diverse activation states, or phenotypes. Modulation microglial phenotype is an appealing neurotherapeutic strategy but a comprehensive study classical more novel phenotypic markers in vitro lacking. The aim this was outline the temporal expression battery from polarised microglia generate tool for screening immunomodulatory potential...
Activated microglia play a central role in the inflammatory and excitotoxic component of various acute chronic neurological disorders. However, mechanisms leading to their activation latter context are poorly understood, particularly involvement N-methyl-D-aspartate receptors (NMDARs), which critical for excitotoxicity neurons. We hypothesized that express functional NMDARs would trigger neuronal cell death brain by modulating inflammation.We demonstrate murine human nervous system these...
ObjectiveWe aimed to explore the added value of common machine learning (ML) algorithms for prediction outcome moderate and severe traumatic brain injury.Study Design SettingWe performed logistic regression (LR), lasso regression, ridge with key baseline predictors in IMPACT-II database (15 studies, n = 11,022). ML included support vector machines, random forests, gradient boosting artificial neural networks were trained using same predictors. To assess generalizability predictions, we...
Background This study provides a detailed imaging assessment in large series of patients infected with coronavirus disease 2019 (COVID-19) and presenting neurologic manifestations. Purpose To review the MRI findings associated acute manifestations COVID-19. Materials Methods was cross-sectional conducted between March 23 May 7, 2020, at Pitié-Salpêtrière Hospital, reference center for COVID-19 Paris area. Adult were included if they had diagnosis severe respiratory syndrome 2 (SARS-CoV-2)...
According to rodent models of postoperative cognitive decline, activation the innate immune response following aseptic surgical trauma results in elaboration hippocampal proinflammatory cytokines, which are capable disrupting long-term potentiation, neurobiologic correlate memory. The authors hypothesize that recruitment bone marrow-derived macrophages plays a causal role these processes, resulting memory dysfunction.Clodrolip injection (liposomal formulation clodronate) before stabilized...
Abstract Background: Aseptic trauma engages the innate immune response to trigger a neuroinflammatory reaction that results in postoperative cognitive decline. The authors sought determine whether high-mobility group box 1 protein (HMGB1), an ubiquitous nucleosomal protein, initiates this process through activation and trafficking of circulating bone marrow–derived macrophages brain. Methods: effects HMGB1 on memory (using trace fear conditioning) were tested adult C57BL/6J male mice;...
Brain-derived neurotrophic factor (BDNF) plays a prominent role in neuroprotection against perinatal brain injury. Dexmedetomidine, selective agonist of α2-adrenergic receptors, also provides glutamate-induced damage. Because adrenergic receptor agonists can modulate BDNF expression, our goal was to examine whether dexmedetomidine's neuroprotective effects are mediated by modulation mouse injury.The protective injury and dexmedetomidine alone or combination with either neutralizing antibody...
Microglia of the developing brain have unique functional properties but how their activation states are regulated is poorly understood. Inflammatory microglia in still-developing preterm-born infants associated with permanent neurological sequelae 9 million every year. Investigating regulators microglial across models neuroinflammation-mediated injury (mouse, zebrafish) and primary human mouse we found using analysis genes proteins that a reduction Wnt/β-catenin signalling necessary...
Background and Purpose— Vascular endothelial growth factor (VEGF) expression is elevated in human brain arteriovenous malformations (bAVM). We have developed a bAVM model the adult mouse by focal Alk1 gene deletion VEGF stimulation. hypothesized that once abnormal vasculature has been established, tonic stimulation necessary to maintain phenotype, antagonism bevacizumab (Avastin) would reduce vessel density attenuate dysplastic vascular phenotype. Methods— Angiogenesis were induced injection...
Activation of α-7 nicotinic acetylcholine receptor (α-7 nAchR) has a neuro-protective effect on ischemic and hemorrhagic stroke. However, the underlying mechanism is not completely understood. We hypothesized that nAchR agonist protects brain injury after stroke through reduction pro-inflammatory macrophages (M1) oxidative stress. C57BL/6 mice were treated with PHA568487 (PHA, agonist), methyllycaconitine (MLA, antagonist), or saline immediately 24 hours permanent occlusion distal middle...
Bone fracture at the acute stage of stroke exacerbates injury by increasing neuroinflammation. We hypothesize that activation α-7 nicotinic acetylcholine receptor (α-7 nAchR) attenuates neuroinflammation and oxidative stress, reduces brain in mice with bone stroke. Permanent middle cerebral artery occlusion (pMCAO) was performed C57BL/6J followed tibia 1 day later. Mice were treated 0.8 mg/kg PHA 568487 (PHA, nAchR-specific agonist), 6 methyllycaconitine nAchR antagonist), or saline 2 days...
Traumatic brain injury (TBI) is a significant cause of disability, but little known about sex and gender differences after TBI. We aimed to analyze the association between sex/gender, broad range care pathways, treatment characteristics, outcomes following mild moderate/severe performed mixed-effects regression analyses in prospective multi-center Collaborative European NeuroTrauma Effectiveness Research Brain Injury (CENTER-TBI) study, stratified for severity age, adjusted baseline...
Background Embolization of the middle meningeal artery (MMA) has emerged as a potential treatment chronic subdural hematomas (CSDHs). Objective To evaluate impact on recurrence rate postsurgical embolization CSDH in patients with higher than average risk recurrence. Methods A monocentric retrospective study was performed retrospectively collected data. From March 2018 to December 2019, MMA proposed an adjunct postoperative after burr-hole surgery operated for recurrent or independent factor,...
<h3>Importance</h3> A head computed tomography (CT) with positive results for acute intracranial hemorrhage is the gold-standard diagnostic biomarker traumatic brain injury (TBI). In moderate to severe TBI (Glasgow Coma Scale [GCS] scores 3-12), some CT features have been shown be associated outcomes. mild (mTBI; GCS 13-15), distribution and co-occurrence of pathological their prognostic importance are not well understood. <h3>Objective</h3> To identify adverse outcomes after mTBI....
Complex metabolic disruption is a crucial aspect of the pathophysiology traumatic brain injury (TBI). Associations between this and systemic metabolism their potential prognostic value are poorly understood. Here, we aimed to describe serum metabolome (including lipidome) associated with acute TBI within 24 h post-injury, its relationship severity patient outcome. We performed comprehensive metabolomics study in cohort 716 patients non-TBI reference (orthopedic, internal medicine, other...
Abstract Background While the Glasgow coma scale (GCS) is one of strongest outcome predictors, current classification traumatic brain injury (TBI) as ‘mild’, ‘moderate’ or ‘severe’ based on this fails to capture enormous heterogeneity in pathophysiology and treatment response. We hypothesized that data-driven characterization TBI could identify distinct endotypes give mechanistic insights. Methods developed an unsupervised statistical clustering model a mixture probabilistic graphs for...
Abstract Chronic post-concussive symptoms are common after mild traumatic brain injury (mTBI) and difficult to predict or treat. Thalamic functional integrity is particularly vulnerable in mTBI may be related long-term outcomes but requires further investigation. We compared structural MRI resting state 108 patients with a Glasgow Coma Scale (GCS) of 13–15 normal CT, 76 controls. examined whether acute changes thalamic connectivity were early markers for persistent explored neurochemical...
General anesthesia and procedural sedation are common practice for mechanical thrombectomy in acute ischemic stroke. However, risks benefits of each strategy unclear.