Ana Mikolić
A5044895384- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Trauma and Emergency Care Studies
- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Posttraumatic Stress Disorder Research
- Neurosurgical Procedures and Complications
- Resilience and Mental Health
- Radiation Dose and Imaging
- Cerebrospinal fluid and hydrocephalus
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- S100 Proteins and Annexins
- Spinal Fractures and Fixation Techniques
- Software Reliability and Analysis Research
- Health disparities and outcomes
- Machine Learning in Healthcare
- Diverse Interdisciplinary Research Studies
- Suicide and Self-Harm Studies
- Radiomics and Machine Learning in Medical Imaging
- Intracerebral and Subarachnoid Hemorrhage Research
- Hip and Femur Fractures
- Airway Management and Intubation Techniques
- Metabolomics and Mass Spectrometry Studies
- Meta-analysis and systematic reviews
- Intensive Care Unit Cognitive Disorders
Erasmus University Rotterdam
2021-2025
Erasmus MC
2019-2025
University of British Columbia
2023-2025
GF Strong Rehabilitation Centre
2023-2025
Vancouver Coastal Health
2023-2025
Vancouver Coastal Health Research Institute
2024
Burke Foundation
2023
Stiftung Liebenau (Germany)
2022
Integra LifeSciences (United States)
2022
Addenbrooke's Hospital
2022
Traumatic brain injury (TBI) is a significant cause of disability, but little known about sex and gender differences after TBI. We aimed to analyze the association between sex/gender, broad range care pathways, treatment characteristics, outcomes following mild moderate/severe performed mixed-effects regression analyses in prospective multi-center Collaborative European NeuroTrauma Effectiveness Research Brain Injury (CENTER-TBI) study, stratified for severity age, adjusted baseline...
OBJECTIVE The International Mission on Prognosis and Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) Corticosteroid Randomization After Significant Head (CRASH) prognostic models for mortality outcome after traumatic brain injury (TBI) were developed using data from 1984 to 2004. This study examined IMPACT CRASH model performances a contemporary cohort US patients. METHODS prospective 18-center Transforming Research Knowledge (TRACK-TBI) (enrollment years 2014–2018) enrolled...
Men and women differ in outcomes following mild traumatic brain injury (TBI). In the CENTER-TBI study, we previously found that had worse 6-month functional outcome (Glasgow Outcome Score Extended (GOSE)), health-related quality of life (HRQoL), mental health TBI. The aim this study was to investigate whether those differences were mediated by psychiatric history, gender- related sociodemographic variables, or care pathways. We analyzed sex/gender GOSE, generic TBI-specific HRQoL,...
The majority of traumatic brain injuries (TBIs) are categorized as mild, according to a baseline Glasgow Coma Scale (GCS) score 13-15. Prognostic models that were developed predict functional outcome and persistent post-concussive symptoms (PPCS) after mild TBI have rarely been externally validated. We aimed validate predicting 3-12-month Outcome Extended (GOSE) or PPCS in adults with TBI. analyzed data from the Collaborative European NeuroTrauma Effectiveness Research Traumatic Brain Injury...
The incidence of Traumatic Brain Injury (TBI) is increasingly common in older adults aged ≥65 years, forming a growing public health problem. However, are underrepresented TBI research. Therefore, we aimed to provide an overview health-care utilization, and six-month outcomes after their determinants who sustained TBI.We used data from the prospective multi-center Collaborative European NeuroTrauma Effectiveness Research (CENTER-TBI) study. In-hospital post-hospital care utilization were...
After mild traumatic brain injury (mTBI), a substantial proportion of individuals do not fully recover on the Glasgow Outcome Scale Extended (GOSE) or experience persistent post-concussion symptoms (PPCS). We aimed to develop prognostic models for GOSE and PPCS at 6 months after mTBI assess value different categories predictors (clinical variables; questionnaires; computed tomography [CT]; blood biomarkers). From Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain...
Patients with mild traumatic brain injury (mTBI) are at risk for post-concussion (PC) symptoms and post-traumatic stress disorder (PTSD). The co-occurrence of PC PTSD after mTBI in relation to health-related quality life (HRQoL), health care utilization, return work has not yet been investigated. were measured six months post-TBI by respectively the Rivermead Post-Concussion Symptoms Questionnaire (RPQ) Post-Traumatic Stress Disorder Checklist DSM-5 (PCL-5). Of 1566 individuals who met...
Prognostication is challenging in patients with traumatic brain injury (TBI) whom computed tomography (CT) fails to fully explain a low level of consciousness. Serum biomarkers reflect the extent structural damage different way than CT does, but it unclear whether provide additional prognostic value across range abnormalities. This study aimed determine added predictive biomarkers, differentiated by imaging severity. used data from Collaborative European NeuroTrauma Effectiveness Research...
Importance The optimal timing for fixation of extremity fractures after traumatic brain injury (TBI) remains controversial. Objective To investigate whether patients who underwent within 24 hours TBI experienced worse outcomes than those had the procedure or more TBI. Design, Setting, and Participants This cohort study used data from Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. Patients 16 years older with internal met inclusion...
Importance Mental health disorders are common after mild traumatic brain injury (mTBI) and likely exacerbate postconcussive symptoms disability. Early detection could improve clinical outcomes, but the accuracy of mental screening tools in this population has not been well established. Objective To determine diagnostic Patient Health Questionnaire–9 (PHQ-9), Generalizaed Anxiety Disorder–7 (GAD-7), Primary Care PTSD (Posttramatic Stress Disorder) Screen for Diagnostic Statistical Manual...
Post-concussion symptoms (PCS) are often reported as consequences of mild and moderate traumatic brain injury (TBI), but these not well documented in severe TBI. There is a lack agreement to which factors covariates affect the occurrence, frequency, intensity PCS among TBI severity groups. The present study therefore aims examine association between sociodemographic, premorbid, injury-related PCS. A total 1391 individuals (65% male) from CENTER-TBI were included analyses. frequency (number...
Outpatient care following nonhospitalized traumatic brain injury (TBI) is variable, and often sparse. The National Academies of Sciences, Engineering, Medicine's 2022 report on
Background Traumatic brain injury (TBI) is associated with an increased risk of major depressive disorder (MDD) and post-traumatic stress (PTSD). We aimed to identify predictors develop models for the prediction depression PTSD symptoms at 6 months post-TBI. Methods analysed data from Collaborative European NeuroTrauma Effectiveness Research in Brain Injury study. used linear regression model relationship between (Patient Health Questionnaire-9) (PTSD Checklist Diagnostic Statistical Manual...
INTRODUCTION: Early prognosis in TBI is essential to support clinical decision-making, inform patients and relatives, advance research. The IMPACT prognostic model for 6-month outcomes was originally developed from an international dataset of moderate-severe (GCS =12; studies conducted 1984-1997). Multiple external validations have been performed but global data privacy regulations made sharing human subject largely infeasible, preventing validation updating combined contemporary datasets....
This article explores the diagnostic performance of a panel six biomarkers (glial fibrillary acidic protein [GFAP], neurofilament light [NFL], neuron-specific enolase [NSE], S100 calcium-binding B [S100B], total tau [t-tau], and ubiquitin C-terminal hydrolase L1 [UCH-L1]) in context "2023 UK National Institute for Health Care Excellence (NICE) Head Injury: Assessment early management (NG232)" guideline. Emphasis is placed on subjects where clinical equipoise remains concerning decision head...
Objective: Mild traumatic brain injury (mTBI) may be a common precipitant of Somatic Symptom Disorder (SSD). This study examined the prevalence, correlates, predictors, and functional impact SSD after mTBI. Setting: Follow up patients recruited from emergency departments urgent care centers. Participants: Adults with mTBI (N = 476). Design: Secondary analysis clinical trial (Clinicaltrials.gov NCT04704037). Main Measures: Early illness beliefs (Illness Perceptions Questionnaire-Revised;...
The current classification of traumatic brain injury (TBI) primarily uses the Glasgow Coma Scale (GCS) to categorize injuries as mild (GCS 13-15), moderate 9-12), or severe ≤8). However, this system is unsatisfactory, it overlooks variations in severity, clinical needs, and prognosis. A recent report by National Academies Sciences, Engineering, Medicine (USA) recommended updating system, leading a workshop 2024 Institute Neurological Disorders Stroke. This resulted development new clinical,...
Prognostic models can support prevention of mental health complications after mild traumatic brain injury (mTBI). The present study aimed to identify risk factors and develop prognostic model(s) for following mTBI. This secondary analysis data from a randomized controlled trial included 513 adults presenting emergency departments/urgent care centers. Candidate predictors were demographic, injury-related history information collected during medical chart review eligibility screening, scores...
Abstract Background Comparison of patient-reported outcomes in multilingual studies requires evidence the equivalence translated versions questionnaires. The present study examines factorial validity and comparability six language Rivermead Post-Concussion Symptoms Questionnaire (RPQ) administered to individuals following traumatic brain injury (TBI) Collaborative European NeuroTrauma Effectiveness Research (CENTER-TBI) study. Methods Six competing RPQ models were estimated using data from...
Introduction Persistent symptoms after mild traumatic brain injury (mTBI) negatively affect daily functioning and quality of life. Fear avoidance behaviour, a coping style in which people avoid or escape from activities situations that they expect will exacerbate their symptoms, maybe particularly potent modifiable risk factor for chronic disability mTBI. This study evaluate the efficacy graded exposure therapy (GET) reducing persistent following mTBI, with two primary aims: (1) To determine...
Abstract Background Prediction modeling studies often have methodological limitations, which may compromise model performance in new patients and settings. We aimed to examine the relation between quality of development their at external validation. Methods systematically searched for externally validated multivariable prediction models that predict functional outcome following moderate or severe traumatic brain injury. Risk bias applicability was assessed with Of Bias Assessment Tool...