A5088613638- Palliative Care and End-of-Life Issues
- Intensive Care Unit Cognitive Disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Traumatic Brain Injury Research
- Statistical Methods and Inference
- Childhood Cancer Survivors' Quality of Life
- Cardiac Arrest and Resuscitation
- Clinical practice guidelines implementation
- Statistical Methods in Clinical Trials
- Anesthesia and Neurotoxicity Research
- Cardiac, Anesthesia and Surgical Outcomes
- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Pancreatitis Pathology and Treatment
- Obstructive Sleep Apnea Research
- Patient Dignity and Privacy
- Cancer survivorship and care
- Statistical Methods and Bayesian Inference
- Head and Neck Cancer Studies
- Systemic Sclerosis and Related Diseases
- Gastrointestinal disorders and treatments
- Thermal Regulation in Medicine
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Traumatic Brain Injury and Neurovascular Disturbances
University of Göttingen
2014-2025
Universitätsmedizin Göttingen
2017-2025
University Hospital and Clinics
2024
University Medical Center
2024
Outcomes Research Consortium
2023
University of Michigan
2023
Kerckhoff Klinik
2019
Donor-derived cell-free DNA (dd-cfDNA) is a noninvasive biomarker for comprehensive monitoring of allograft injury and rejection in kidney transplantation (KTx). dd-cfDNA quantification copies/mL plasma (dd-cfDNA[cp/mL]) was compared to fraction (dd-cfDNA[%]) at prespecified visits 189 patients over 1 year post KTx. In (N = 15, n 22 samples) with biopsy-proven (BPR), median dd-cfDNA(cp/mL) 3.3-fold dd-cfDNA(%) 2.0-fold higher (82 cp/mL; 0.57%, respectively) than medians Stable Phase 83, 408)...
The dimensionality of depression and anxiety instruments have recently been a source controversy.In European-wide sample patients after Traumatic Brain Injury (TBI), we aim to examine the factorial structure, validity, association Patient Health Questionnaire for (PHQ-9) Generalized Anxiety Disorder (GAD-7) instruments. This study is based on longitudinal observational data. We conducted analyses structure discriminant validity outcomes six-months TBI. also examined prevalence,...
Objective Early disease prediction is challenging in acute pancreatitis (AP). Here, we prospectively investigate whether the microbiome predicts severity of AP (Pancreatitis—Microbiome As Predictor Severity; P-MAPS) early at hospital admission. Design Buccal and rectal microbial swabs were collected from 424 patients with within 72 hours admission 15 European centres. All samples sequenced by full-length 16S rRNA metagenomic sequencing using Oxford Nanopore Technologies. Primary endpoint was...
The objective of this study was to provide a comprehensive examination the relation complicated and uncomplicated mild traumatic brain injury (mTBI) with multidimensional outcomes at three- six-months after TBI. We analyzed data from Collaborative European NeuroTrauma Effectiveness Research (CENTER-TBI) research project. Patients mTBI (Glasgow Coma scale (GCS) score 13-15) enrolled in were differentiated into two groups based on computed tomography (CT) findings: (presence any intracranial...
Clinical trials have demonstrated positive cardiovascular and kidney outcomes of sodium-glucose-co-transporter-2 (SGLT2) inhibitors in adult patients with diabetic other chronic diseases (CKD). Whether benefits extend to children, teenagers, young adults early-stage CKD is unknown. For this reason, the DOUBLE PRO-TECT Alport trial (NCT05944016) will study progression albuminuria syndrome (AS), most common hereditary CKD, assess safety efficacy SGLT2-inhibitor dapagliflozin. Patients living...
We investigate rank‐based studentized permutation methods for the nonparametric Behrens–Fisher problem, that is, inference area under ROC curve. hereby prove distribution of Brunner‐Munzel rank statistic is asymptotically standard normal, even alternative. Thus, incidentally providing hitherto missing theoretical foundation Neubert and Brunner test. In particular, we do not only show its consistency, but also confidence intervals underlying treatment effects can be computed by inverting this...
Donor-derived cell-free DNA (dd-cfDNA) is reportedly a valuable tool for graft surveillance following kidney transplantation (KTx). Possible changes in dd-cfDNA(%) reference values over time have not been evaluated. For long-term monitoring after KTx, host cfDNA might represent biasing factor determinations.Plasma samples were obtained (n = 929) 12-60 months engraftment cross-sectional cohort of 303 clinically stable KTx recipients. Total cfDNA(copies/mL), dd-cfDNA(%), and...
Abstract Background Patients with congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD) and dementia are underrepresented in specialist palliative home care (SPHC). However, the complexity of their conditions requires collaboration between general practitioners (GPs) SPHC teams timely integration into to effectively meet needs. Objective To facilitate joint planning transfer patients advanced non-malignant SPHC. Methods A two-arm, unblinded, cluster-randomised...
The European Larynx Organ Preservation Study (ELOS; NCT06137378) is a prospective, randomized, open-label, two-armed parallel group controlled, phase II multicenter larynx organ preservation (LOP) trial in locoregionally advanced (LA) stage III, IVA/B head and neck squamous cell carcinoma of the or hypopharynx (LHSCC) amenable for total laryngectomy (TL) with PD-L1 expression within tumor tissue biopsy, calculated as CPS ≥ 1. Induction chemotherapy (IC) docetaxel cisplatin (TP) followed by...
Depression and anxiety are common following traumatic brain injury (TBI). Understanding their prevalence interplay within the first year after TBI with differing severities may improve patients' outcomes TBI. Individuals a clinical diagnosis of recruited for large European collaborative longitudinal study CENTER-TBI were screened patient-reported major depression (MD) generalized disorder (GAD) at three, six, twelve months post-injury (N = 1683). Data analyzed using autoregressive...
OBJECTIVE Incidental durotomy during degenerative lumbar spine surgeries poses a complex medical challenge. Despite its relatively common occurrence, consensus on management remains elusive due to the absence of robust, high-level evidence, resulting in significant variations practice across institutions. The aim this survey was assess current practices Germany regarding early mobilization versus bed rest postoperative incidental surgery estimate need for randomized clinical trial. METHODS A...
Postoperative delirium (POD) is a severe complication following cardiac surgery and associated with increased morbidity mortality. The impact of intra- early postoperative factors on the occurrence POD remains controversial. To close this gap, we investigated their predictive values for POD. We performed prospective observational study that aimed to FIND DElirium RIsk (FINDERI) patients undergoing elective surgery. was assessed using Confusion Assessment Method (CAM) algorithm. Intra- were...
Introduction Glaucoma is one of the most common causes blindness and affects more than 70 million people worldwide. The disease characterised by loss retinal ganglion cells associated with a progressive optic neuropathy, resulting in an impairment visual functions, for example, field loss. Nowadays, only modifiable risk factor increase intraocular pressure, its treatment to lower this pressure medication, laser or surgery avoid progression. New methods preventing reversing vision are thus...
Background: Lumen apposing metal stents (LAMS) are widely used to drain walled-off necrosis (WON). LAMS occlusion is considered a significant clinical problem and identification of risk factors for could contribute novel preventive strategies. A previous study suggested contradictory effects proton pump inhibitor (PPI) intake on the necrosectomy rate. Methods: We conducted European-wide multicenter retrospective cohort assessing WONs drained by LAMS. Primary aims were assess strength an...
Abstract Introduction Whole-body cryotherapy (WBC) has shown to be beneficial in the treatment of fibromyalgia (FM). There is cumulative evidence that cytokines play a crucial role FM. It’s unknown whether clinical effects WBC can demonstrated at molecular level and how long last. Methods We compared serial (6 sessions (− 130 °C 6 weeks) FM patients healthy controls (HC). Primary outcome was change pain (visual analogue scale 0–100 mm) after sessions. Secondary outcomes were disease activity...
Abstract ESCAPE Evaluation of a patient‐centred biopsychosocial blended collaborative care pathway for the treatment multimorbid elderly patients. Therapeutic Area Healthcare interventions management older patients with multiple morbidities. Aims Multi‐morbidity is an increasing challenge healthcare systems in ageing societies. This comprehensive cohort study embedded randomized controlled trial tests integrated model Hypothesis A holistic, pro‐active 9‐month intervention based on (BCC)...
Previous studies have demonstrated the efficacy of rehabilitation after a cardiovascular procedure. Especially older and multimorbid patients benefit from cardiac Prehabilitation prior to procedures may also positive effects on patients' pre- postoperative outcomes. Results current meta-analysis show that prehabilitation can improve perioperative outcomes alleviate adverse effects. Germany currently lacks structured program for patients, which is coordinated across healthcare sectors.In...
Post-concussion symptoms (PCS) are often reported as consequences of mild and moderate traumatic brain injury (TBI), but these not well documented in severe TBI. There is a lack agreement to which factors covariates affect the occurrence, frequency, intensity PCS among TBI severity groups. The present study therefore aims examine association between sociodemographic, premorbid, injury-related PCS. A total 1391 individuals (65% male) from CENTER-TBI were included analyses. frequency (number...