A5031007856- Biomedical Text Mining and Ontologies
- Head and Neck Cancer Studies
- Topic Modeling
- Tracheal and airway disorders
- Bayesian Modeling and Causal Inference
- Clinical practice guidelines implementation
- Hedgehog Signaling Pathway Studies
- Machine Learning in Healthcare
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Semantic Web and Ontologies
- Head and Neck Surgical Oncology
- Radiomics and Machine Learning in Medical Imaging
- Tumors and Oncological Cases
- Toxin Mechanisms and Immunotoxins
- Ear and Head Tumors
- Electronic Health Records Systems
- Data Quality and Management
- Lipoproteins and Cardiovascular Health
- Ferroptosis and cancer prognosis
- Global Cancer Incidence and Screening
- Esophageal Cancer Research and Treatment
- Data Visualization and Analytics
- Cancer-related molecular mechanisms research
- Artificial Intelligence in Healthcare
University Hospital Leipzig
2015-2025
Leipzig University
2013-2025
Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde
2024
Medizinische Hochschule Hannover
2021
The European Larynx Organ Preservation Study (ELOS; NCT06137378) is a prospective, randomized, open-label, two-armed parallel group controlled, phase II multicenter larynx organ preservation (LOP) trial in locoregionally advanced (LA) stage III, IVA/B head and neck squamous cell carcinoma of the or hypopharynx (LHSCC) amenable for total laryngectomy (TL) with PD-L1 expression within tumor tissue biopsy, calculated as CPS ≥ 1. Induction chemotherapy (IC) docetaxel cisplatin (TP) followed by...
Adding pembrolizumab, an anti-PD-1 antibody approved for treatment of head and neck squamous cell carcinoma (HNSCC) to neoadjuvant (induction-) chemotherapy utilizing docetaxel cisplatin (TP) followed by radiotherapy may improve outcome in larynx organ-preservation (LOP) that is investigated the European Larynx-Organ preservation Study (ELOS). As biomarkers response TP pembrolizumab +TP are missing but include cytokines, this work aims on determining cytokines potentially linked as...
Abstract Objective Patients with recurrent head and neck carcinoma are considered for salvage surgery if resectability clear margins is achievable. However, postoperative complications such as wound healing disorders pharyngocutaneous fistulas remain significant challenges. While various reconstructive surgical techniques exist, supportive vacuum therapy—both external endoluminal—has been explored an alternative treatment modality. Type of Study We present a case report 60-year-old male...
Background: Obtaining large amounts of real patient data involves great efforts and expenses, processing this is fraught with protection concerns. Consequently, sharing might not always be possible, particularly when large, open science datasets are needed, as for AI development. For such purposes, the generation realistic synthetic may solution. Our project aimed to generate cancer use case laryngeal cancer. Methods: We used open-source software Synthea programmed an additional module...
Introduction Larynx organ preservation (LOP) in locoregional-advanced laryngeal and hypopharyngeal squamous cell carcinoma (LA-LHSCC) being only R0-resectable (clear margins > 5 mm) by total laryngectomy (TL) is desirable. Based on tumor-specific survival (TSS) overall (OS) data from the RTOG 91-11 trial meta-analyses of randomized clinical trials (RCTs), cisplatin-based concurrent radiochemotherapy (CRT) discussed superior to induction chemotherapy followed radiotherapy (IC+RT) TL...
The increase in diagnostic and therapeutic procedures the treatment of oncological diseases, as well limited capacity experts to provide information, necessitates development therapy decision support systems (TDSS). We have developed a model that integrates available patient information tumor characteristics. They are assessed according their relevance evaluating optimal option. Our is based on Bayesian networks (BN) which integrate patient-specific data with expert-based implemented...
Overexpression of the Hedgehog (HH) signalling pathway has been described in several malignancies and is associated with a poor prognosis. HH blockade reduces tumour growth vitro vivo. We aimed to determine whether head neck squamous cell carcinomas (HNSCCs) express proteins comparison healthy mucosa.Formalin-fixed paraffin-embedded tissue sections 10 patients HNSCC were stained fluorescence-labelled antibodies for cytokeratin (SHH, PTCH1/2, SMO, Gli1-3) photographs taken laser scanning...
For many complex diseases, finding the best patient-specific treatment decision is difficult for physicians due to limited mental capacity. Clinical support systems based on Bayesian networks (BN) can provide a probabilistic graphical model integrating all necessary aspects relevant making. Such models are often manually created by clinical experts. The modeling process consists of conducted collecting information entities, and achieved through defining relations entities their direct...
New diagnostic methods and novel therapeutic agents spawn additional heterogeneous information, leading to an increasingly complex decision-making process for optimal treatment of cancer. A great amount information is collected in organ-specific multidisciplinary tumor boards (MDTBs). By considering the patient's properties, molecular pathological test results, comorbidities, MDTB has consent evidence-based decision. Immunotherapies are important today's cancer treatment, resulting detailed...
Making complex medical decisions is becoming an increasingly challenging task due to the growing amount of available evidence consider and higher demand for personalized treatment patient care. IT systems provision clinical decision support (CDS) can provide sustainable relief if are automatically evaluated processed. In this paper, we propose approach quantifying similarity between new previously recorded cases enable significant knowledge transfer reasoning tasks on a patient-level....
Background/Objectives: Laryngeal squamous cell carcinoma (LSCC) is among most frequent malignancies of the head and neck. Recent oncologic research focusses on advanced rather than early stages. Thus, we aimed to improve knowledge concerning prognostic factors survival in glottic (GC) supraglottic cancer (SGC). Methods: We retrospectively investigated patients diagnosed 2007 2020 with stage I or II GC (ICD-10-C32.0) SGC (ICD-10-C32.1, C32.8 C32.9). For precise discrimination SGC, pathology...
The larynx organ preservation (LOP) trial DeLOS-II enrolled n = 173 patients with advanced laryngeal/hypopharyngeal squamous cell carcinoma (LHSCC) amenable (only curatively resectable) through total laryngectomy (TL) to receive induction chemotherapy (IC) TPF [docetaxel (T), cisplatin (P), and 5-fluorouracil (F)] (arm A, 85 patients) or additional cetuximab (E) weekly B, 88 patients). Responders endoscopic estimated tumor surface shrinkage (ETSS) ≥30% after 1 cycle IC (IC-1) received a...
Treatment decisions in oncology are demanding and affect survival, general health, quality of life. Expert systems can handle the complexity oncological field. We propose application a hybrid modeling approach for decision support models consisting expert-based implementation model structure machine-learning (ML) based parameter generation. demonstrate our treatment oropharyngeal cancer.We created clinical on Bayesian Networks iteratively optimized its characteristics using structured...