A5052265399- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Psoriasis: Treatment and Pathogenesis
- Autoimmune and Inflammatory Disorders Research
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Chronic Myeloid Leukemia Treatments
- Vitamin K Research Studies
- Pain Mechanisms and Treatments
- Platelet Disorders and Treatments
- Health and Medical Studies
- Cell Adhesion Molecules Research
- Monoclonal and Polyclonal Antibodies Research
- Inflammatory Myopathies and Dermatomyositis
- Infrared Thermography in Medicine
- Drug Solubulity and Delivery Systems
- Body Contouring and Surgery
- Pluripotent Stem Cells Research
- Innovations in Medical Education
- Advanced Drug Delivery Systems
- Nuclear Receptors and Signaling
- Immunodeficiency and Autoimmune Disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- PI3K/AKT/mTOR signaling in cancer
Fraunhofer Institute for Translational Medicine and Pharmacology
2016-2025
Fraunhofer Research Institution for Materials Recycling and Resource Strategies IWKS
2023
Fraunhofer Institute for Molecular Biology and Applied Ecology
2015-2022
Institute of Molecular Biology
2019
University Hospital Frankfurt
2001-2013
Goethe University Frankfurt
2001-2013
Heidelberg University
2002
Background Hereditary angioedema ( HAE ) is a rare disease caused by C 1‐esterase inhibitor 1‐ INH deficiency, characterized periodic attacks of acute edema affecting subcutaneous SC tissues and mucous membranes. Human concentrate given intravenously IV effective safe, but venous access may be difficult. We compared administration human pasteurized with respect to pharmacokinetics, pharmacodynamics, safety. Study Design Methods This was prospective, randomized, open‐label, crossover study....
Abstract Seeding of hematopoietic progenitor cells (HPC) into the bone marrow requires a complex interaction between cell membrane and adhesion systems signaling pathways. We established multicellular, spheroid coculture model to study HPC migration in three-dimensional stromal environment. Here, entry primary CD34+ stroma spheroids was independent integrins very late antigen (VLA)-4, VLA-5, lymphocyte function-associated antigen-1, chemokine receptor CXCR4. Experiments using panel bacterial...
Abstract Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of BCR-ABL-mediated transformation in vitro and vivo. To investigate whether PTP1B modulates the biological effects abl kinase inhibitor STI571 BCR-ABL-positive cells, we transfected Philadelphia chromosome–positive (Ph+) chronic myeloid leukemia cell-derived K562 cells with either wild-type (K562/PTP1B), substrate-trapping dominant-negative mutant (K562/D181A), or empty vector (K562/mock). Cells were cultured without...
Neuropathic pain is a debilitating and commonly treatment-refractory condition requiring novel therapeutic options. Accumulating preclinical studies indicate that the potassium channel Slack (KNa1.1) contributes to processing of neuropathic pain, activators, when injected into mice, ameliorate pain-related hypersensitivity. However, whether activation might reduce in humans remains elusive. Here, we evaluated tolerability analgesic efficacy loxapine, first-generation antipsychotic drug...
Abstract Objective To investigate the efficacy and safety of rituximab + LEF in patients with RA. Methods In this investigator-initiated, randomized, double-blind, placebo-controlled phase 3 trial, an inadequate response to who had failed one or more DMARD were randomly assigned 2:1 i.v. 1000 mg placebo on day 1 15 plus ongoing oral LEF. The primary outcome was difference between ≥50% improvement ACR criteria (ACR50 response) rates at week 24 (P ≤ 0.025). Secondary endpoints included...
Objectives To evaluate the ability of fluorescence-optical imaging (FOI) to detect preclinical musculoskeletal inflammatory signs in patients with skin psoriasis at risk developing psoriatic arthritis (PsA). Methods This investigator-initiated prospective exploratory study evaluated adult complaints and/or nail within last 6 months. Patients underwent a comprehensive rheumatological clinical examination (CE) along ultrasound (MSUS) and FOI both hands single visit. CE–/MSUS–/FOI+ findings had...
Persistent and, in particular, neuropathic pain is a major healthcare problem with still insufficient pharmacological treatment options. This triggered research activities aimed at finding analgesics novel mechanism of action. Results these efforts will need to pass through the phases drug development, which experimental human models are established components e.g. implemented as chemical hyperalgesia induced by capsaicin. We ranking various readouts capsaicin-based model respect most...
The influence of sex on treatment outcomes during interleukin-12/23 therapy in patients with psoriatic arthritis (PsA) has not been explored. To conduct exploratory post hoc analyses sex-stratified data from the MUST trial, an investigator-initiated, multicentre, phase 3b study which active PsA initiating open-label ustekinumab were randomised to placebo or methotrexate (MTX). We evaluated baseline characteristics, key and adverse events stratified by sex, a focus that did include...
<h3>Background</h3> Psoriasis (Pso) is one of the most common chronic inflammatory skin diseases in Europe. Psoriatic arthritis (PsA) closely associated to Pso; manifestation appears usually years before PsA-related symptoms emerge. Up 40% Pso patients develop PsA. Biomarkers for its early detection are missing by reasons distinct clinical manifestations. In PsA manifestations, changes synovial vascularisation combined with increased expression proangiogenic factors appear first. Therefore,...
General practitioners, specialists, occupational and physical therapists, nursing services other professional groups are all involved in the treatment of patients with rheumatoid arthritis. This study aims to describe interprofessional cooperation daily ambulatory care from perspective a general practitioner.The cross-sectional investigated between practitioners (n=121 68 medical practices) several health providers Hesse Rhineland Palatinate, Germany, February September 2017. It was part...
<h3>Background</h3> Use of biologicals such as Rituximab (RTX) in Rheumatoid Arthritis (RA) is effective and often only licensed combination with Methotrexate (MTX). In cases contraindications to or intolerances, other cDMARDs are frequently used routine care without data from RCTs. <h3>Objectives</h3> To demonstrate safety efficacy RTX Leflunomide (LEF) a multicenter randomized placebo (PLA) controlled clinical trial Germany. <h3>Methods</h3> A total 189 patients active RA (DAS28 >3.2 at...
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. Patients can present with nodules, abscesses up to fistulas, or sinus tracts in intertriginous body parts. Occlusion of the sebaceous gland unit leads its rupture, subsequent exuberant immune response. Given there still no causative therapy, better understand HS and develop novel therapeutic concepts, research activities field are constantly growing. Primary cells, blood ex vivo explant cultures from patients have been...
<h3>Background</h3> Use of biologicals such as Rituximab (RTX) in Rheumatoid Arthritis (RA) is effective and often only licensed combination with Methotrexate (MTX). In cases contraindications to or intolerances MTX other cDMARDs are frequently used without robust data from RCTs. addition, different strategies retreatment RTX available. <h3>Objectives</h3> To demonstrate efficacy on patient-reported outcomes (PROs) leflunomide (LEF) a multicenter investigator-initiated placebo...
Background: Psoriasis (Pso) is one of the most common chronic inflammatory skin diseases in Europe. Psoriatic arthritis (PsA) closely associated to Pso whereas manifestation appears usually years before PsA-related symptoms emerge. Up 30% patients develop PsA, biomarkers for its early detection are major importance. In changes synovial vascularisation appear first. Imaging might be useful musculoskeletal disease. Fluorescence-optical imaging (FOI) a new method detect microvascularisation...
Background: The optimal dose of rituximab in combination with leflunomide patients rheumatoid arthritis (RA) is not known. Methods: In Part 1 (previously reported) the investigator-initiated AMARA study (EudraCT 2009-015950-39; ClinicalTrials.gov NCT01244958), improvements at week (W)24 were observed randomized to + compared placebo leflunomide. reported here (Part 2), responders received 500 or 1000 mg W24/26 plus ongoing Patients baseline their eventual W24 treatment group. 2 primary...
<h3>Background</h3> Psoriasis (Pso) is one of the most common chronic inflammatory skin disease in Europe. Psoriatic arthritis (PsA) closely associated to Pso; manifestation appears usually years before PsA-related symptoms emerge. Up 30% Pso patients develop PsA; its concrete prevalence still unclear. Questionnaires for detection PsA (PASE, PEST, GEPARD) are validated tools use dermatology practice with different sensitivity and specificity levels. Fluorescence-optical imaging technique a...
<h3>Background</h3> BDMARD treatment in PsA patients usually requires failure/intolerance to csDMARDs. The value of MTX combination with bDMARDs is still unclear; an increase efficacy expected polyarthritis. We designed investigator-initiated, randomized, placebo-controlled trial (IIT) active examine if outcomes UST (either newly initiated or ongoing) are different from only (+PBO), especially focus on peripheral arthritic dominant PsA. <h3>Objectives</h3> To compare ACR20/50/70 and MDA...
<h3>Background</h3> BDMARD treatments in patients with psoriatic arthritis (PsA) are initiated after insufficient response to csDMARD either monotherapy or by parallel continuing csDMARDs. Here, the value of MTX combination bDMARDs PsA is still unclear. We designed an investigator-initiated, randomized, placebo-controlled trial (IIT) active examine potential impact MTX-continuation -initiation newly started UST on different outcomes beyond clinical examination (MSUS; PsASon22 score [1])....