A5012267945- Pharmacovigilance and Adverse Drug Reactions
- Pharmaceutical Practices and Patient Outcomes
- Pharmaceutical studies and practices
- Asthma and respiratory diseases
- Health Systems, Economic Evaluations, Quality of Life
- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Meta-analysis and systematic reviews
- Pharmacological Effects and Toxicity Studies
- Medication Adherence and Compliance
- Drug-Induced Adverse Reactions
- Antibiotics Pharmacokinetics and Efficacy
- Statistical Methods in Clinical Trials
- Antibiotic Use and Resistance
- Epilepsy research and treatment
- Cardiac electrophysiology and arrhythmias
- Venous Thromboembolism Diagnosis and Management
- Musculoskeletal pain and rehabilitation
- Respiratory Support and Mechanisms
- Heart Failure Treatment and Management
- Airway Management and Intubation Techniques
- Pain Management and Opioid Use
- Inhalation and Respiratory Drug Delivery
Witten/Herdecke University
2015-2025
Helios Universitätsklinikum Wuppertal
2015-2024
Jena University Hospital
2024
University Hospital Leipzig
2022
Helios Kliniken
2012-2015
University of Duisburg-Essen
2004
Technische Universität Dresden
2003
Certain drugs are classified as potentially inappropriate medications (PIM) for the elderly because they carry an increased risk of adverse drug events in this patient group. PIM lists from other countries limited usefulness Germany different on market each country and prescribing practices vary well. Thus, a list was developed specifically use Germany.A preliminary suitable German created basis selective literature search qualitative analysis published international lists. The final by...
ABSTRACT Purpose German hospital reimbursement modalities changed as a result of the introduction Diagnosis Related Groups (DRG) in 2004. Therefore, no data on direct costs adverse drug reactions (ADRs) resulting admissions to departments internal medicine are available. The objective was quantify ADR‐related economic burden (direct costs) hospitalizations wards Germany. Methods Record‐based study analyzing patient records about 57 000 between 2006 and 2007 Net Regional Pharmacovigilance...
Studies on drug utilization usually do not allow direct cross-national comparisons because of differences in the respective applied methods. This study aimed to compare time trends BZDs prescribing by applying a common protocol and analyses plan seven European electronic healthcare databases.Crude standardized prevalence rates from 2001-2009 were calculated databases Spain, United Kingdon (UK), The Netherlands, Germany Denmark. Prevalence was stratified age, sex, BZD type [(using ATC codes),...
Abstract Purpose There is widespread concern about increases in antibiotic use, but comparative data from different European countries on rates of use are lacking. This study was designed to measure and understand the variation utilization across five countries. Methods Seven healthcare databases with access primary care Denmark, Germany, Netherlands, Spain UK were used compare point 1‐year‐period prevalence between 2004 2009. Descriptive analyses stratified by gender, age type antibiotic....
Aims To estimate the incidence of direct oral anticoagulant drug (DOAC) use in patients with nonvalvular atrial fibrillation and to describe user treatment characteristics 8 European healthcare databases representing 6 countries. Methods Longitudinal utilization study from January 2008 December 2015. A common protocol approach was applied. Annual period incidences standardisation by age sex were performed. Dose adjustment related change renal function as well concomitant potentially...
Background: Studies evaluating the impact of age and potentially inappropriate medication (PIM) on avoidable adverse drug reactions (ADRs) are scarce.Methods: In this prospective, multi-center, long-term (8.5 years) observational study, we analysed ADRs leading to hospitalization in departments internal medicine. causality preventability were assessed using standardised algorithms. PIM was defined based PRISCUS-list. Multivariate analyses estimation ADR incidence rates conducted.Results: Of...
Summary Objective The annual prevalence of antiepileptic drug ( AED ) prescribing reported in the literature differs considerably among E uropean countries due to use different type data sources, time periods, population distribution, and methodologic differences. This study aimed measure across seven routine health care databases S pain, D enmark, N etherlands, U nited K ingdom, Germany using a standardized methodology investigate sources variation. Methods Analyses on s were stratified by...
The introduction of direct oral anticoagulants (DOACs) has broadened the treatment arsenal for nonvalvular atrial fibrillation, but observational studies on benefit-risk balance DOACs compared to vitamin K antagonists (VKAs) are needed. aim this study was characterize risk major bleeding in DOAC users using longitudinal data collected from electronic health care databases 4 different EU-countries analysed with a common protocol.A cohort conducted among new (≥18 years) or VKAs fibrillation...
Abstract Objective To establish the risk of major bleeding in direct oral anticoagulant (DOAC) users (overall and by class) versus vitamin K antagonist (VKA) users, using health care databases from four European countries six provinces Canada. Methods A retrospective cohort study was performed according to a similar protocol. First‐users VKAs or DOACs with diagnosis non‐valvular atrial fibrillation (NVAF) were included. The main outcome interest secondary outcomes included gastrointestinal...
The utilisation of routine clinical data is increasingly vital for analysing care quality and supporting decisions. This study within the POLAR_MI consortium developed a FHIR-based distributed validation method to quantify amitriptyline prescriptions in patients aged ≥65 years. Data from 10 German university hospitals were aggregated validated through bidirectional checks, achieving 100% accuracy inpatient 82.7% outpatient identification. High inter-rater reliability (Krippendorff's Alpha =...
Abstract In this single-center observational study with 1,206 participants, we prospectively evaluated SARS-CoV-2-antibodies (anti-S RBD) and vaccine-related adverse drug reactions (ADR) after basic booster immunization BNT162b2- ChAdOx1-S-vaccines in four vaccination protocols: Homologous BNT162b2-schedule second at either three or six weeks, homologous ChAdOx1-S-vaccination heterologous ChAdOx1-S/BNT162b2-schedule, each 12 weeks. All participants received a BNT162b2 booster. Blood samples...
Chronic non-cancer pain (CNCP) is a common condition worldwide. The disease burden influenced not only by itself, but also psychiatric co-morbidities, which aggravate symptoms, generally negatively influence therapies, and may thereby lead to frustration, resignation, or withdrawal. A growing body of evidence suggests that sex gender aspects CNCP management as the experience pain, emotions associated with it, expression differ between women men. In addition, doctor-patient communication...
Respiratory drugs are widely used in children to treat labeled and non-labeled indications but only some data available quantifying comprehensively off-label usage. Thus, we aim analyse drug utilisation prescribing of respiratory focusing on age- indication-related use. Patients aged ≤18 years documented the Bavarian Association Statutory Health Insurance Physicians database (approx. 2 million children) between 2004 2008 were included our study. Annual period prevalence rates (PPRs) per...