A5044156447- Traumatic Brain Injury and Neurovascular Disturbances
- Trauma and Emergency Care Studies
- Traumatic Brain Injury Research
- Cardiac Arrest and Resuscitation
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Sepsis Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Cerebrospinal fluid and hydrocephalus
- Radiation Dose and Imaging
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Radiomics and Machine Learning in Medical Imaging
- Respiratory Support and Mechanisms
- S100 Proteins and Annexins
- Acute Ischemic Stroke Management
- Autopsy Techniques and Outcomes
- Lung Cancer Research Studies
- Teratomas and Epidermoid Cysts
- Emergency and Acute Care Studies
- Spinal Fractures and Fixation Techniques
- Machine Learning in Healthcare
- Nosocomial Infections in ICU
- Resilience and Mental Health
- Economic and Environmental Valuation
- Ultrasound in Clinical Applications
Pauls Stradiņš Clinical University Hospital
2012-2025
University of Groningen
2022
Karolinska Institutet
2022
University Hospital of North Norway
2021
Oslo University Hospital
2021
University of Oslo
2021
Medical University of Vienna
2021
Centre Hospitalier Régional et Universitaire de Nancy
2021
University Hospital Heidelberg
2021
Heidelberg University
2021
This European Organisation for Research and Treatment of Cancer phase III trial assesses whether adjuvant whole-brain radiotherapy (WBRT) increases the duration functional independence after surgery or radiosurgery brain metastases.Patients with one to three metastases solid tumors (small-cell lung cancer excluded) stable systemic disease asymptomatic primary WHO performance status (PS) 0 2 were treated complete randomly assigned WBRT (30 Gy in 10 fractions) observation (OBS). The end point...
This phase III trial compared adjuvant whole-brain radiotherapy (WBRT) with observation after either surgery or radiosurgery of a limited number brain metastases in patients stable solid tumors. Here, we report the health-related quality-of-life (HRQOL) results.HRQOL was secondary end point trial. HRQOL assessed at baseline, 8 weeks, and then every 3 months for years European Organisation Research Treatment Cancer (EORTC) Quality Life Questionnaire C30 Brain Module. The following six primary...
Background. Intracranial dermoid cysts (IDC) are rare benign congenital intracranial lesions. In the case of IDC rupture, these lesions may manifest clinically. Cysts be visualized on non-enhanced computed tomography (NECT) and magnetic resonance imaging (MRI), facilitating discussions between clinicians radiologists to determine cyst content potential dissemination in cases rupture. This report describes an rupture presenting as fat-containing subarachnoid space ventricular system,...
Studies on decompressive craniectomy (DCE) after a malignant middle cerebral artery (MCA) stroke in selected population show an increased probability of survival without increasing the number very severely disabled. Cerebral infarct volume (CIV) as triage criterion for performing surgery has not been discussed literature. The aim this study was to investigate value CIV and initial National Institutes Health Stroke Scale (NIHHS) Glasgow Coma (GCS) scores possible criteria surgical treatment...
We previously reported the unexpected finding of significantly improved survival for newly diagnosed glioblastoma in patients when radiation therapy (RT) was initiated later (>4 wk post-op) compared with earlier (≤2 post-op). In that analysis, data were analyzed from 2855 16 NRG Oncology/Radiotherapy Oncology Group (RTOG) trials conducted prior to era concurrent temozolomide (TMZ) RT. now report on 1395 glioblastomas 2 studies, treated RT and TMZ followed by adjuvant TMZ. Our hypothesis has...
Background and Clinical Significance: Intracranial dermoid cysts (IDCs) are rare benign congenital intracranial lesions. In the case of IDC rupture, these lesions may manifest clinically. Cysts be visualized on non-enhanced computed tomography (NECT) magnetic resonance imaging (MRI), facilitating discussions between clinicians radiologists to determine cyst content potential dissemination in cases rupture. This report describes an rupture presenting as fat-containing subarachnoid space...
Background and Objectives: In recent years Electronic scooters (E-Scooters) have gained popularity, whether for private use or as a publicly available transportation method. With introduction of these vehicles, reports E-Scooter related accidents surged, sparking public debate concern. Aim this study was to analyse epidemiological data, characteristics severity traumatic brain injury (TBI) accidents. Materials Methods: This retrospective case series evaluated 28 patients who were admitted...
Importance The optimal timing for fixation of extremity fractures after traumatic brain injury (TBI) remains controversial. Objective To investigate whether patients who underwent within 24 hours TBI experienced worse outcomes than those had the procedure or more TBI. Design, Setting, and Participants This cohort study used data from Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. Patients 16 years older with internal met inclusion...
Background and Objectives: In recent years, electronic scooters (e-scooters) have gained popularity, whether for private use or as a publicly available transportation method. With the introduction of these vehicles, reports e-scooter-related accidents surged, sparking public debate concern. The aim this study was to analyze epidemiological data, characteristics, severity traumatic brain injury (TBI) related e-scooter accidents. Materials Methods: This retrospective case series evaluated...
Abstract Background Fearing increased myelotoxicity, many practitioners adjust the body surface area (BSA)-calculated doses in obese patients. Regarding temozolomide (TMZ), a prior study suggested men with BSA >2 m2 may experience toxicity; however, surprisingly, inverse observation was noted women, ie, <2 associated higher toxicity. To further clarify this issue, data derived from large clinical trial were analyzed. Methods The incidence of grade 3 and 4 myelotoxicity newly...
INTRODUCTION: We previously reported the unexpected finding that survival was significantly improved in patients with newly-diagnosed GBM when radiation initiated later (>4 weeks post-op) compared to earlier (≤2 post-op). That analysis included 2855 from 16 RTOG trials conducted prior era of concurrent temozolomide (TMZ) RT. now report on 1127 two studies involving GBM, treated RT + TMZ followed by adjuvant TMZ. Our hypothesis has a synergistic/radiosensitizing mechanism, making timing less...
BACKGROUND: There is limited evidence regarding which salvage treatment approach may be of most benefit for glioblastoma patients who progress following standard chemo-radiation treatment. METHODS: This secondary analysis RTOG 0525 investigated the effect reirradiation or systemic in with tumor progression. Survival time was calculated from date first progression estimated and compared between receiving neither radiation therapy, therapy alone, any Patient characteristics were groups Cox...