Jean Darcourt
A5024116273- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological Complications and Syndromes
- Moyamoya disease diagnosis and treatment
- Peripheral Artery Disease Management
- Stroke Rehabilitation and Recovery
- Vascular Malformations Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Cerebral Venous Sinus Thrombosis
- Antiplatelet Therapy and Cardiovascular Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Aortic Disease and Treatment Approaches
- Platelet Disorders and Treatments
- Neurosurgical Procedures and Complications
- Pituitary Gland Disorders and Treatments
- MRI in cancer diagnosis
- Ophthalmology and Eye Disorders
- Electrical and Bioimpedance Tomography
- Neurological Disease Mechanisms and Treatments
- Renal and Vascular Pathologies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Meningioma and schwannoma management
Centre Hospitalier Universitaire de Toulouse
2019-2025
Clinique des Cèdres
2025
Université de Toulouse
2017-2024
Institut des Maladies Métaboliques et Cardiovasculaires
2018-2023
Hôpital Purpan
2016-2023
Inserm
2018-2023
Medical University of Vienna
2023
Centre d’Investigation Clinique 1436
2023
Hôpital Paule de Viguier
2018-2022
Centre Hospitalier de l’Université de Montréal
2022
General anesthesia and procedural sedation are common practice for mechanical thrombectomy in acute ischemic stroke. However, risks benefits of each strategy unclear.
Background and Purpose: Mechanical thrombectomy (MT) is the recommended treatment for acute ischemic stroke caused by anterior circulation large vessel occlusion. However, despite a high rate of reperfusion, clinical response to successful MT remains highly variable in early time window where optimal imaging selection criteria have not been established. We hypothesize that baseline perfusion profile may help forecast this setting. Methods: conducted prospective multicenter cohort study...
The purpose of this study is to present the authors' medium-term results, with special emphasis on complications, occlusion rate aneurysm sac (digital subtraction angiography [DSA] and MRI), fate cortical branches perforating arteries covered ("jailed") by flow diverter (FD) stent.
Importance The benefit of reperfusion therapies for acute ischemic stroke decreases over time. This decreasing is presumably due to the disappearance salvageable brain tissue (ie, penumbra). Objective To study association between onset-to-imaging time and penumbral volume in patients with a large vessel occlusion. Design, Setting, Participants A retrospective, multicenter, cross-sectional was conducted from January 1, 2015, June 30, 2022. limit selection bias, were selected (1) prospective...
Background Despite known limitations, the decision to operate on abdominal aortic aneurysm (AAA) is primarily basis of measurement maximal diameter. Purpose To identify volumetric and computational fluid dynamics parameters predict AAAs that are likely progress in size. Materials Methods This study, part a multicenter prospective registry (NCT01599533), included 126 patients with AAA. Patients were sorted into stable (≤10-mL increase volume) progression (>10-mL groups. Initial AAA...
Half of the patients with large vessel occlusion (LVO)-related acute ischemic stroke (AIS) who undergo endovascular reperfusion are dead or dependent at 3 months. We hypothesize that in addition to established prognostic factors, baseline imaging profile predicts outcome among reperfusers.Consecutive receiving treatment (EVT) within 6 hours after onset Thrombolysis In Cerebral Infarction (TICI) 2b, 2c and revascularization were included. Poor was defined by a modified Rankin scale (mRS) 3-6...
Mechanical thrombectomy (MT) is not recommended for acute stroke with large vessel occlusion (LVO) and a volume of irreversibly injured tissue ("core"). Perfusion imaging may identify subset patients core who benefit from MT.We compared two cohorts LVO-related (>50 ml on diffusion-weighted-imaging or CT-perfusion using RAPID), available perfusion imaging, treated within 6 hours onset by either MT + Best Medical Management (BMM) in one prospective study, BMM alone the pre-MT era registry....
Mechanical thrombectomy (MT) associated with the best medical treatment (BMT) has recently shown efficacy for management of acute ischemic stroke (AIS) secondary to a large vessel occlusion. However, evidence is lacking regarding benefit MT more distal occlusions.
Background and Purpose— Our goal was to evaluate whether the presence of a low signal intensity known as susceptibility vessel sign (SVS) on T2*-gradient echo imaging sequence predictive arterial recanalization early clinical improvement after mechanical thrombectomy. Methods— This observational study based prospective database acute ischemic strokes treated by Inclusion criteria were patients with anterior stroke, diagnosed magnetic resonance imaging, including sequence, Two independent...
M2 segment occlusions represent approximately one-third of non-lacunar ischemic stroke and can lead to permanent neurological deficits. Various techniques are available for mechanical thrombectomy beyond the circle Willis, but data evaluating their effectiveness safety lacking.A retrospective review patients with undergoing from 13 centers in North American Europe was performed. Tandem or multiple-territory were excluded. The primary outcome 90-day modified Rankin Scale reperfusion rates...
Patients treated with acute carotid stenting (CAS) may have higher odds of a favorable outcome than those without CAS during thrombectomy in tandem occlusions. Antiplatelet therapy is associated to avoid stent thrombosis, which occurs around 20% patients and negatively impacts outcomes. In this study we compared two antiplatelet strategies occlusion strokes intracranial clinical practice.The Endovascular Treatment Ischemic Stroke Registry an ongoing prospective observational involving 21...
There is to date limited evidence that revascularization strategies are associated with improved functional outcome in children acute ischemic stroke (AIS).To report clinical outcomes and provide estimates of strategy safety efficacy profiles intravenous thrombolysis (IVT) and/or endovascular treatment (EVT) AIS.The KidClot multicenter nationwide cohort study retrospectively collected data (neonates excluded) AIS recanalization between January 1, 2015, May 31, 2018. Data analysis was...
Background Endovascular treatment (EVT) for basilar artery occlusions (BAO) is associated with a higher rate of futile recanalization compared anterior circulation procedures. We aimed to identify the incidence and predictors poor clinical outcome despite successful reperfusion in current practice. Methods used data from ETIS (Endovascular Treatment Ischemic Stroke) registry, prospective multicenter observational registry stroke treated EVT France. Patients undergoing acute BAO January 2014...
Introduction: C-reactive protein (CRP) is a prototypic inflammation marker, with elevated levels associated an increased risk of cerebrovascular events. To determine whether CRP could be useful biomarker stroke etiology, we investigated expression in acute ischemic (AIS) clots from large-artery atherosclerosis (LAA), cardio-embolism (CE) and cryptogenic (Crypt) subtypes. Patients methods: We analysed clot samples AIS patients (LAA, CE, Crypt; n = 50 each), collected across five centres...
In acute ischemic stroke due to anterior large vessel occlusion (AIS-LVO), accessing the target occluded for mechanical thrombectomy (MT) is sometimes impossible through femoral approach. We aimed evaluate safety and efficacy of direct carotid artery puncture (DCP) MT in patients with failed alternative vascular access.We retrospectively analyzed data from 45 centers France, Switzerland Germany two research networks January 2015 July 2019. collected physician-centered on DCP practices...
Background: Leptomeningeal enhancement (LME) is a key feature of Susac syndrome (SuS) but only occasionally depicted on post-contrast T1-weighted images (T1-WI). Objective: As fluid-attenuated inversion recovery (FLAIR) may be more sensitive, our aim was to assess LME in SuS this sequence. Methods: From 2010 2020, 20 patients with definite diagnosis were retrospectively enrolled multicentre study. Two radiologists independently assessed the number FLAIR and T1-WI acquisitions performed...
<h3>BACKGROUND AND PURPOSE:</h3> Rescue endovascular and pharmacologic approaches are increasingly being adopted after recanalization failure of acute large-vessel occlusion strokes with mechanical thrombectomy, encouraging results. The safety efficacy glycoprotein IIb/IIIa inhibitors in ischemic stroke have been investigated, though cangrelor, a recent intravenous P2Y12-receptor inhibitor rapid onset/offset action short half-life, may be valuable option. We compared the cangrelor those for...