A5057954827- Autoimmune Neurological Disorders and Treatments
- Peripheral Neuropathies and Disorders
- Genetics and Neurodevelopmental Disorders
- RNA regulation and disease
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Neuroimaging Techniques and Applications
- Cytomegalovirus and herpesvirus research
- Multiple Sclerosis Research Studies
- Neurogenesis and neuroplasticity mechanisms
- interferon and immune responses
- Ion channel regulation and function
- Cellular transport and secretion
- Polyomavirus and related diseases
- Immunodeficiency and Autoimmune Disorders
- Metabolism and Genetic Disorders
- Vestibular and auditory disorders
- Epilepsy research and treatment
- Adenosine and Purinergic Signaling
- Herpesvirus Infections and Treatments
- Calcium signaling and nucleotide metabolism
- 3D Printing in Biomedical Research
- Long-Term Effects of COVID-19
- CNS Lymphoma Diagnosis and Treatment
- Tuberous Sclerosis Complex Research
University of Münster
2017-2025
University Hospital Münster
2017-2025
Martha-Maria Hospital
2021-2024
Heinrich Heine University Düsseldorf
2021-2023
Lausitzer Seenland Klinikum
2022
Universität Ulm
2021
Jena University Hospital
2018-2021
Ludwig-Maximilians-Universität München
2021
Institute of Neuroimmunology of the Slovak Academy of Sciences
2021
Medizinische Hochschule Hannover
2021
<h3>Background and Objectives</h3> To determine the real-world use of rituximab in autoimmune encephalitis (AE) to correlate treatment with long-term outcome. <h3>Methods</h3> Patients NMDA receptor (NMDAR)-AE, leucine-rich glioma-inactivated-1 (LGI1)- AE, contactin-associated protein-like-2 (CASPR2)-AE, or glutamic acid decarboxylase 65 (GAD65) disease from GErman Network for Research on AuToimmune Encephalitis who had received at least 1 dose a control cohort non–rituximab-treated patients...
Anti-IgLON5 disease is a newly defined clinical entity characterized by progressive course with high disability and mortality rate. While precise pathogenetic mechanisms remain unclear, features characteristic of both autoimmune neurodegenerative diseases were reported. Data on immunotherapy are limited, its efficacy remains controversial. In this study, we retrospectively investigated an anti-IgLON5 cohort special focus clinical, serological genetic predictors the response long-term...
<h3>Objective</h3> To assess intensive care unit (ICU) complications, their management, and prognostic factors associated with outcomes in a cohort of patients autoimmune encephalitis (AE). <h3>Methods</h3> This study was an observational multicenter registry consecutively included diagnosed AE requiring Neuro-ICU treatment between 2004 2016 from 18 tertiary hospitals. Logistic regression models explored the influence diagnostic findings on dichotomized (0–3 vs 4–6) modified Rankin Scale...
<h3>Background and Objectives</h3> CSF in antibody-defined autoimmune encephalitis (AE) subtypes shows subtype-dependent degrees of inflammation ranging from rare often mild to frequent robust. AEs with NMDA receptor antibodies (NMDAR-E) leucine-rich glioma-inactivated protein 1 (LGI1-E) represent opposite ends this spectrum: NMDAR-E typically frequent/robust LGI1-E rare/mild inflammation. For a more in-depth analysis, we characterized findings acute, therapy-naive multicentric,...
Abstract Autoimmune neurological syndromes (AINS) with autoantibodies against the 65 kDa isoform of glutamic acid decarboxylase (GAD65) present limbic encephalitis, including temporal lobe seizures or epilepsy, cerebellitis ataxia, and stiff-person-syndrome overlap forms. Anti-GAD65 are also detected in autoimmune diabetes mellitus, which has a strong genetic susceptibility conferred by human leukocyte antigen (HLA) non-HLA genomic regions. We investigated predisposition patients anti-GAD65...
Autoimmune limbic encephalitis (ALE) presents with new-onset mesial temporal lobe seizures, progressive memory disturbance, and other behavioral cognitive changes. CD8 T cells are considered to play a key role in those cases where autoantibodies (ABs) target intracellular antigens or no ABs were found. Assessment of such patients clinical challenge, novel noninvasive imaging biomarkers urgently needed. Here, we demonstrate that visualization the translocator protein (TSPO) [
Abstract Autoantibodies against contactin-associated protein 2 (Caspr2) not only induce limbic autoimmune encephalitis but are also associated with pain conditions. Here, we analyzed clinical data on in a large cohort of patients included into the German Network for Research Autoimmune Encephalitis. Out 102 our cohort, was frequent symptom (36% all patients), often severe (63.6% pain) and/or even major (55.6% pain). Pain phenotypes differed between patients. Cluster analysis revealed two...
Objective Limbic encephalitis (LE) comprises a spectrum of inflammatory changes in affected brain structures including the presence autoantibodies and lymphoid cells. However, potential distinct lymphocyte subsets alone to elicit key clinicopathological sequelae LE potentially inducing temporal lobe epilepsy (TLE) with chronic spontaneous seizures hippocampal sclerosis (HS) is unresolved. Methods Here, we scrutinized pathogenic consequences emerging from CD8 + T cells targeting neurons by...
Abstract Objective Direct pathogenic effects of autoantibodies to the 65 kDa isoform glutamic acid decarboxylase (GAD65) in autoimmune limbic encephalitis (LE) have been questioned due its intracellular localization. We therefore hypothesized a role for T cells. Methods assessed magnet resonance imaging, neuropsychological and peripheral blood, CSF flow cytometry data 10 patients with long‐standing GAD65‐LE compared controls cross‐sectional manner. These were related each other within group...
Autoimmune Encephalitis (AE) spans a group of non-infectious inflammatory conditions the central nervous system due to an imbalanced immune response. Aiming elucidate pathophysiological mechanisms AE, we applied unsupervised proteomic approach analyze cerebrospinal fluid (CSF) protein profile AE patients with autoantibodies against N-methyl-d-aspartate receptor (NMDAR) (n = 9), leucine-rich glioma-inactivated 1 (LGI1) or glutamate decarboxylase 65 (GAD65) 8) compared 9 relapsing-remitting...
Autoimmune encephalitis (AIE) is a disabling inflammatory condition of the brain deemed to be due dysregulated immune response. Viral infections and malignancies together with certain genetic polymorphisms are thought contribute pathogenesis AIE, yet exact mechanisms remain insufficiently understood. Diagnosis AIE currently relies on clinical consensus criteria. However, diagnostic workup can challenging in some cases, potentially delaying treatment initiation associated poor outcomes. This...
Autoimmune limbic encephalitis is an inflammatory condition confined to the system of brain that deemed be due a dysregulated immune response. However, exact pathophysiological mechanisms remain elusive. Diagnosis autoimmune currently relies on clinical consensus criteria. diagnostic workup can challenging, potentially delaying treatment initiation associated with poor outcomes. We retrospectively identified 640 patients (81 encephalitis, 148 relapsing-remitting multiple sclerosis, 197...
Abstract Epilepsy is one of the most common neurological disorders in world. Common epileptic drugs generally affect ion channels or neurotransmitters and prevent emergence seizures. However, up to a third patients suffer from drug-resistant epilepsy, there an urgent need develop new therapeutic strategies that go beyond acute antiepileptic (antiseizure) therapies towards therapeutics also might have effects on chronic epilepsy comorbidities such as cognitive decline depression. The...
Abstract Background Immune dysregulation is a hallmark of autoimmune diseases the central nervous system (CNS), characterized by an excessive immune response, and primary CNS tumors (pCNS-tumors) showing highly immunosuppressive parenchymal microenvironment. Methods Aiming to provide novel insights into pathogenesis autoimmunity cerebral tumor immunity, we analyzed peripheral blood (PB) cerebrospinal fluid (CSF) 81 limbic encephalitis (ALE), 148 relapsing–remitting multiple sclerosis (RRMS),...
Abstract Background Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS), characterized by inflammatory and neurodegenerative processes. Despite demyelination being a hallmark disease, how it relates to neurodegeneration has still not been completely unraveled, research ongoing into these processes can be tracked non-invasively. Magnetic resonance imaging (MRI) derived brain network characteristics, which closely mirror relate functional impairment, recently...
Abstract Autoimmune limbic encephalitis (ALE) is the most common type of autoimmune (AIE). Subacute memory disturbance, temporal lobe seizures, and psychiatric symptoms are clinical hallmarks disease. However, little known on factors contributing to cognitive functioning in ALE. Hence, we here investigate major determinants In a retrospective analysis 102 patients with ALE, first compared verbal learning capacity, nonverbal attentional executive by absence or presence different types neural...
Temporal lobe epilepsy with amygdala enlargement (TLE-AE) is increasingly recognized as a distinct adult electroclinical syndrome. However, functional consequences of morphological alterations the in TLE-AE are poorly understood. Here, two emotional stimulation designs were employed to investigate subjective rating and skin conductance responses sample treatment-naïve patients suspected or confirmed autoimmune (n = 12) comparison healthy control group 16). A subgroup completed follow-up...
Autoimmune limbic encephalitis (ALE) is characterized by memory impairment, psychiatric symptoms, and epileptic seizures. Though, the neuropsychological profile of ALE not yet well defined. However, there some evidence that impairments might exceed those related to system different autoantibodies (AABs) are associated with distinguishable pattern impairments. We provide a comprehensive presentation performance in an immune therapy-naïve sample. retrospectively analyzed 69 immunotherapy-naïve...
Herpes simplex virus-1 has been identified as the trigger factor in certain cases of NMDA-receptor autoimmune encephalitis. We report on a 67-year-old female patient, who was severely affected by post-herpetic Her symptoms did not improve under methylprednisolone pulse therapy and plasma exchange acyclovir prophylaxis. She received protein A immunoadsorption long-term immunosuppression with rituximab. Under treatment, activated T-cells well B- cells decreased peripheral blood cerebrospinal...
Erythropoietin (EPO) has been shown to improve cognitive function in mammals as well patients of psychiatric diseases by directly acting on the brain. In addition, EPO attenuates synaptic transmission and enhances short- long-term plasticity hippocampus mice, although there are still many discrepancies between different studies. It suggested that divergences studies take root in-vivo application schemata or trophic effects EPO. current study, we investigated direct slices prelimbic cortex...
Cellular and humoral immunity towards distinct onconeural antigens is the hallmark of paraneoplastic neurological diseases (PNDs). Stable formation immunoglobulin (Ig) G antibodies to particular occurs in majority cases, whereas persistent coexistence specific for multiple a relatively rare phenomenon certain malignant tumors like small cell lung cancer (SCLC). We here describe antigen spreading 70-year-old Caucasian male with PND due SCLC. Onconeural may be promoted by two mutually...
N-Methyl-D-aspartate (NMDA) receptors (NMDARs) are among the most important excitatory neurotransmitter in human brain. Autoantibodies to NMDAR cause frequent form of autoimmune encephalitis involving autoantibody-mediated receptor cross-linking and subsequent internalization antibody-receptor complex. This has been deemed represent predominant antibody effector mechanism depleting from synaptic extra-synaptic neuronal cell membrane. To assess detail molecular mechanisms autoantibody-induced...