Gabriel González‐Escamilla
A5011665420- Functional Brain Connectivity Studies
- Multiple Sclerosis Research Studies
- Advanced Neuroimaging Techniques and Applications
- Neurological disorders and treatments
- Neural dynamics and brain function
- Neuroinflammation and Neurodegeneration Mechanisms
- EEG and Brain-Computer Interfaces
- Parkinson's Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Advanced MRI Techniques and Applications
- Memory and Neural Mechanisms
- Transcranial Magnetic Stimulation Studies
- Bioinformatics and Genomic Networks
- Epilepsy research and treatment
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neural Engineering
- Medical Imaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Neural and Behavioral Psychology Studies
- Long-Term Effects of COVID-19
- Cerebrospinal fluid and hydrocephalus
- Botulinum Toxin and Related Neurological Disorders
- Neonatal and fetal brain pathology
- Conferences and Exhibitions Management
University Medical Center of the Johannes Gutenberg University Mainz
2017-2025
Johannes Gutenberg University Mainz
2017-2025
Klinik und Poliklinik für Neurologie
2021-2025
Saarland University
2024-2025
University Medical Center
2025
University College London
2024
Nicolae Testemițanu State University of Medicine and Pharmacy
2022
Heinrich Heine University Düsseldorf
2022
Creative Commons
2022
Philipps University of Marburg
2022
Amyloid deposition and neurofibrillary degeneration in Alzheimer's disease specifically affect discrete neuronal systems, but the underlying mechanisms that render some brain regions more vulnerable to pathology than others remain largely unknown. Here we studied molecular properties these distinct regional vulnerabilities by analysing disease-typical neuroimaging patterns of amyloid neurodegeneration relation gene expression profiles human brain. Graded brain-wide vulnerability were...
Brain connectivity profiles seeding from deep brain stimulation (DBS) electrodes have emerged as informative tools to estimate outcome variability across DBS patients. Given the limitations of acquiring and processing patient-specific diffusion-weighted imaging data, a number studies employed normative atlases human connectome. To date, it remains unclear whether information would strengthen accuracy such analyses. Here, we compared similarities differences between patient-specific,...
Neuroinflammation is a pathophysiological hallmark of multiple sclerosis and has close mechanistic link to neurodegeneration. Although this potentially targetable, robust translatable models reliably quantify track neuroinflammation in both mice humans are lacking. The choroid plexus (ChP) plays pivotal role regulating the trafficking immune cells from brain parenchyma into cerebrospinal fluid (CSF) recently attracted attention as key structure initiation inflammatory responses. In...
One of the biggest challenges in managing multiple sclerosis is heterogeneity clinical manifestations and progression trajectories. It still remains to be elucidated whether this reflected by discrete immune signatures blood as a surrogate disease pathophysiology. Accordingly, individualized treatment selection based on immunobiological principles not feasible. Using two independent multicentric longitudinal cohorts patients with early ( n = 309 discovery 232 validation), we were able...
Multiple sclerosis (MS) disease risk is associated with reduced sun-exposure. This study assessed the relationship between measures of sun exposure (vitamin D [vitD], latitude) and MS severity in setting two multicenter cohort studies (nNationMS = 946, nBIONAT 990). Additionally, effect-modification by medication photosensitivity-associated MC1R variants was assessed. High serum vitD a score (MSSS), for relapses, lower disability accumulation over time. Low latitude higher vitD, MSSS, fewer...
Deep brain stimulation (DBS), specifically thalamic DBS, has achieved promising results to reduce seizure severity and frequency in pharmacoresistant epilepsies, thereby establishing it for clinical use. The mechanisms of action are, however, still unknown. We evidenced the networks directly modulated by centromedian (CM) nucleus-DBS responsible outcomes a cohort patients uniquely diagnosed with generalized epilepsy. Preoperative imaging long-term (2-11 years) data from ten epilepsy (mean...
Abstract As the global health crisis unfolded, many academic conferences moved online in 2020. This move has been hailed as a positive step towards inclusivity its attenuation of economic, physical, and legal barriers effectively enabled individuals from groups that have traditionally underrepresented to join participate. A number studies outlined how moving made it possible gather more community increased opportunities for with various constraints, e.g., caregiving responsibilities. Yet,...
Cognitive deficits are among the main disabling symptoms in COVID-19 patients and post-COVID syndrome (PCS). Within brain regions, hippocampus, a key region for cognition, has shown vulnerability to SARS-CoV-2 infection. Therefore, vivo detailed evaluation of hippocampal changes PCS patients, validated on post-mortem samples at acute phase, would shed light into relationship between cognition.Hippocampal subfields volume, microstructure, perfusion were evaluated 84 compared 33 controls....
Abstract To optimally adjust our behavior to changing environments we need both the speed of decisions and movements. Yet little is known about extent which these processes are controlled by common or separate mechanisms. Furthermore, while previous evidence from computational models empirical studies suggests that basal ganglia play an important role during adjustments decision-making, it remains unclear how this implemented. Leveraging opportunity directly access subthalamic nucleus in...
Abstract Increasing evidence suggests a considerable role of pre-movement beta bursts for motor control and its impairment in Parkinson’s disease. However, whether occur during precise prolonged movements if they affect fine remains unclear. To investigate the within-movement control, we here combine invasive electrophysiological recordings clinical deep brain stimulation subthalamic nucleus 19 patients with disease performing context-varying task that comprised template-guided free spiral...
Resting-state eyes-closed electroencephalographic (rsEEG) alpha rhythms are dominant in posterior cortical areas healthy adults and abnormal subjective memory complaint (SMC) persons with Alzheimer's disease amyloidosis. This exploratory study 161 SMC participants tested the relationships between those seed-based resting-state functional magnetic resonance imaging (rs-fMRI) connectivity thalamus visual networks as a function of brain amyloid burden, revealed by positron emission tomography...
Disentangling brain aging from disease-related neurodegeneration in patients with multiple sclerosis (PwMS) is increasingly topical. The brain-age paradigm offers a window into this problem but may miss disease-specific effects. In study, we investigated whether model might complement the gap (BAG) by capturing aspects unique to MS.
Dopamine dysfunction is associated with a wide range of neuropsychiatric disorders commonly treated pharmacologically or invasively. Recent studies provide evidence for nonpharmacological and noninvasive alternative that allows similar manipulation the dopaminergic system: transcranial direct current stimulation (tDCS). In rodents, tDCS has been shown to increase neural activity in subcortical parts system, recent humans over prefrontal regions induces striatal dopamine release affects...
Objective To investigate whether choroid plexus volumes in subacute coronavirus disease 2019 (COVID‐19) patients with neurological symptoms could indicate inflammatory activation or barrier dysfunction and assess their association clinical data. Methods Choroid were measured 28 COVID‐19 via cerebral magnetic resonance imaging (MRI), compared those infection‐triggered non‐COVID‐19 encephalopathy (n = 25), asymptomatic individuals after 21), healthy controls 21). Associations serum markers...
Fatigue is a frequent and severe symptom in multiple sclerosis (MS), but its pathophysiological origin remains incompletely understood. We aimed to examine the predictive value of subcortical gray matter volumes for fatigue severity at disease onset after 4 years by applying structural equation modeling (SEM).This multicenter cohort study included 601 treatment-naive patients with MS first demyelinating event. All underwent standardized 3T magnetic resonance imaging (MRI) protocol. A...
Anxiety, often seen as comorbidity in multiple sclerosis (MS), is a frequent neuropsychiatric symptom and essentially affects the overall disease burden. Here, we aimed to decipher anxiety-related networks functionally connected atrophied areas patients suffering from MS.Using 3-T MRI, atrophy maps were generated by correlating longitudinal cortical thinning with severity of anxiety symptoms MS patients. To determine brain regions these maps, applied technique termed "atrophy network...
The identification of prognostic markers in early multiple sclerosis (MS) is challenging and requires reliable measures that robustly predict future disease trajectories. Ideally, such should make inferences at the individual level to inform clinical decisions. This study investigated value longitudinal structural networks 5-year Expanded Disability Status Scale (EDSS) progression patients with relapsing-remitting MS (RRMS). We hypothesized network measures, derived from MRI, outperform...
Cocaine use disorder (CUD) is a worldwide public health condition that suggested to induce pathological changes in macrostructure and microstructure. Repetitive transcranial magnetic stimulation (rTMS) has gained attention as potential treatment for CUD symptoms. Here, we sought elucidate whether rTMS induces white matter (WM) microstructure frontostriatal circuits after 2 weeks of therapy patients with test baseline WM the same affects clinical improvement. This study consisted 2-week,...