Anke Salmen
A5040106901- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Polyomavirus and related diseases
- Systemic Lupus Erythematosus Research
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Systemic Sclerosis and Related Diseases
- Rheumatoid Arthritis Research and Therapies
- Long-Term Effects of COVID-19
- Cytokine Signaling Pathways and Interactions
- Amyotrophic Lateral Sclerosis Research
- Ultrasound Imaging and Elastography
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Systems, Economic Evaluations, Quality of Life
- Immunodeficiency and Autoimmune Disorders
- Vaccine Coverage and Hesitancy
- Asthma and respiratory diseases
- Chronic Lymphocytic Leukemia Research
- Powdery Mildew Fungal Diseases
- Monoclonal and Polyclonal Antibodies Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Medicinal Plants and Bioactive Compounds
- Mast cells and histamine
- COVID-19 Clinical Research Studies
- T-cell and Retrovirus Studies
University Hospital of Bern
2016-2025
University of Bern
2016-2025
St. Josef-Hospital
2016-2025
Ruhr University Bochum
2016-2025
Medical University of Vienna
2017-2024
Universität Innsbruck
2024
Population Health Research Institute
2024
McMaster University
2024
University of Basel
2024
University of Glasgow
2022-2023
There is a lack of validated biomarkers for disability progression independent relapse activity (PIRA) in multiple sclerosis (MS).
<h3>Importance</h3> The mechanisms driving neurodegeneration and brain atrophy in relapsing multiple sclerosis (RMS) are not completely understood. <h3>Objective</h3> To determine whether disability progression independent of relapse activity (PIRA) patients with RMS is associated accelerated tissue loss. <h3>Design, Setting, Participants</h3> In this observational, longitudinal cohort study median (IQR) follow-up 3.2 years (2.0-4.9), data were acquired from January 2012 to September 2019 a...
Importance Mechanisms contributing to disability accumulation in multiple sclerosis (MS) are poorly understood. Blood neurofilament light chain (NfL) level, a marker of neuroaxonal injury, correlates robustly with disease activity people MS (MS); however, data on the association between NfL level and have been conflicting. Objective To determine whether when levels elevated context confirmed worsening (CDW). Design, Setting, Participants This study included 2 observational cohorts: results...
Histopathologic studies have identified immunoglobulin (Ig) deposition and complement activation as contributors of CNS tissue damage in multiple sclerosis (MS). Intrathecal IgM synthesis is associated with higher MS disease activity severity, the strongest complement-activating immunoglobulin. In this study, we investigated whether components (CCs) products (CAPs) are increased persons MS, especially those an intrathecal synthesis, they severity progression.
Genome-wide study in Germans identifies four novel multiple sclerosis risk genes and confirms already known gene loci.
BackgroundWe aim to evaluate serum neurofilament light chain (sNfL), indicating neuroaxonal damage, as a biomarker at diagnosis in large cohort of early multiple sclerosis (MS) patients.MethodsIn multicentre prospective longitudinal observational cohort, patients with newly diagnosed relapsing-remitting MS (RRMS) or clinically isolated syndrome (CIS) were recruited between August 2010 and November 2015 22 centers. Clinical parameters, MRI, sNfL levels (measured by single molecule array)...
To determine the prevalence of antibodies to Epstein-Barr virus (EBV) in a large cohort patients with early multiple sclerosis (MS).Serum samples were collected from 901 clinically isolated syndrome (CIS) or relapsing-remitting (RRMS) participating German National MS cohort, prospective stringent inclusion criteria. nuclear antigen (EBNA)-1 and viral capsid (VCA) measured diluted sera by chemiluminescence immunoassays (CLIAs). Sera EBNA-1 VCA antibody-negative retested undiluted an EBV IgG...
Abstract Segmentation of white matter lesions and deep grey structures is an important task in the quantification magnetic resonance imaging multiple sclerosis. In this paper we explore segmentation solutions based on convolutional neural networks (CNNs) for providing fast, reliable segmentations grey-matter multi-modal MR imaging, performance these methods when applied to out-of-centre data. We trained two state-of-the-art fully CNN architectures 2016 MSSEG training dataset, which was...
Background Obesity reportedly increases the risk for developing multiple sclerosis (MS), but little is known about its association with disability accumulation. Methods This nationwide longitudinal cohort study included 1066 individuals newly diagnosed MS from German National cohort. Expanded Disability Status Scale (EDSS) scores, relapse rates, MRI findings and choice of immunotherapy were compared at baseline years 2, 4 6 between obese (body mass index, BMI ≥30 kg/m 2 ) non-obese (BMI...
Progression independent of relapse activity (PIRA) is a crucial determinant overall disability accumulation in multiple sclerosis (MS). Accelerated brain atrophy has been shown patients experiencing PIRA. In this study, we assessed the relation between PIRA and neurodegenerative processes reflected by (1) longitudinal spinal cord (2) paramagnetic rim lesions (PRLs). Besides, same relationship was investigated progressive MS (PMS). Last, explored value cross-sectional volumetric measurements...
One of the biggest challenges in managing multiple sclerosis is heterogeneity clinical manifestations and progression trajectories. It still remains to be elucidated whether this reflected by discrete immune signatures blood as a surrogate disease pathophysiology. Accordingly, individualized treatment selection based on immunobiological principles not feasible. Using two independent multicentric longitudinal cohorts patients with early ( n = 309 discovery 232 validation), we were able...
The detection of new or enlarged white-matter lesions is a vital task in the monitoring patients undergoing disease-modifying treatment for multiple sclerosis. However, definition ‘new enlarged’ not fixed, and it known that lesion-counting highly subjective, with high degree inter- intra-rater variability. Automated methods lesion quantification, if accurate enough, hold potential to make consistent repeatable. majority segmentation algorithms are evaluated their ability separate...
<h3>Importance</h3> Reliable biomarkers associated with disability worsening in multiple sclerosis (MS) are still needed. <h3>Objective</h3> To determine a possible association of intrathecal IgG synthesis and early as measured by Expanded Disability Status Scale (EDSS) scoring patients relapsing-remitting MS or clinically isolated syndrome. <h3>Design, Setting, Participants</h3> Cerebrospinal fluid measurements clinical data from the observational longitudinal German national cohort were...
Multiple sclerosis (MS) disease risk is associated with reduced sun-exposure. This study assessed the relationship between measures of sun exposure (vitamin D [vitD], latitude) and MS severity in setting two multicenter cohort studies (nNationMS = 946, nBIONAT 990). Additionally, effect-modification by medication photosensitivity-associated MC1R variants was assessed. High serum vitD a score (MSSS), for relapses, lower disability accumulation over time. Low latitude higher vitD, MSSS, fewer...
Objective To investigate the longitudinal dynamics of serum glial fibrillary acidic protein (sGFAP) and neurofilament light chain (sNfL) levels in people with multiple sclerosis (pwMS) under B‐cell depleting therapy (BCDT) their capacity to prognosticate future progression independent relapse activity (PIRA) events. Methods A total 362 pwMS (1,480 samples) starting BCDT Swiss Multiple Sclerosis (MS) Cohort were included. sGFAP 2,861 control persons (4,943 provided normative data calculate...
To assess clinical characteristics, distribution of disease-modifying treatments (DMTs), and neuropsychological symptoms in a large cohort patients with early-stage MS.The German National MS Cohort is multicenter prospective longitudinal study that has recruited DMT-naive clinically isolated syndrome (CIS) relapsing-remitting (RRMS) since 2010. We evaluated their baseline characteristics the prevalence symptoms.Of 1,124 patients, 2.2:1 female-to-male ratio median age at onset 31.71 years...
Introduction Post-COVID-19 syndrome affects approximately 10-25% of people suffering from COVID-19 infection, irrespective initial severity. Fatigue is one the major symptoms, occurring in 30-90% with post-COVID-19 syndrome. This study aims at describing factors associated fatigue seen our newly established Post-Covid clinic. Methods retrospective single center included 42 consecutive patients treated Department Neurology, University Hospital Bern, between 11/2020 and05/2021. Clinical...
The limited efficacy of glucocorticoids (GCs) during therapy acute relapses in multiple sclerosis (MS) leads to long-term disability. We investigated the potential vitamin D (VD) enhance GC and mechanisms underlying this VD/GC interaction. In vitro, receptor (GR) expression levels were quantified by ELISA induction T cell apoptosis served as a functional readout assess synergistic 1,25(OH)2D3 (1,25D)/GC effects. Experimental autoimmune encephalomyelitis (MOG35–55 EAE) was induced mice with...
Background: In multiple sclerosis (MS), the frequency of hypogammaglobulinemia is unknown. We aimed to evaluate reduced immunoglobulin (Ig) concentrations and its association with immunotherapy disease course in two independent MS cohorts. Methods: our retrospective cross-sectional study, patients control head or neck pain from Bern University Hospital (Bern, Switzerland) Eginition (Athens, Greece) were included. The lower limits normal (LLN) for serum Ig concentration IgG < 700 mg/dl,...
Abstract Pain is frequent in multiple sclerosis (MS) and includes different types, with neuropathic pain (NP) being most closely related to MS pathology. However, prevalence estimates vary largely, causal relationships between biopsychosocial factors are largely unknown. Longitudinal studies might help clarify the determinants of MS. To this end, we analyzed data from 410 patients newly diagnosed clinically isolated syndrome or relapsing-remitting participating prospective multicenter German...
Post-COVID-19 syndrome affects approximately 10-25% of people after a COVID-19 infection, irrespective initial severity. The aim this project was to assess the clinical characteristics, course, and prognosis post-COVID-19 using systematic multidimensional approach.An online survey with suspected confirmed syndrome, distributed via Swiss support groups, social media, our consultation, performed. A total 8 post-infectious domains were assessed 120 questions. Data collected from October 15...
Cognitive impairment (CI) affects approximately one-third of the patients with early multiple sclerosis (MS) and clinically isolated syndrome (CIS). Little is known about factors predicting CI progression after initial diagnosis. Neuropsychological screening data from baseline 1-year follow-up a prospective multicenter cohort study (NationMS) involving 1123 newly diagnosed MS or CIS were analyzed. Employing linear multilevel models, we investigated whether demographic, clinical conventional...