A5086238032- Neonatal and fetal brain pathology
- Epilepsy research and treatment
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Urinary Bladder and Prostate Research
- Multiple Sclerosis Research Studies
- Functional Brain Connectivity Studies
- Fetal and Pediatric Neurological Disorders
- Cerebrovascular and Carotid Artery Diseases
- EEG and Brain-Computer Interfaces
- Acute Ischemic Stroke Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Pelvic floor disorders treatments
- Meningioma and schwannoma management
- Ultrasound Imaging and Elastography
- MRI in cancer diagnosis
- Vestibular and auditory disorders
- Hearing Loss and Rehabilitation
- Sexual function and dysfunction studies
- Radiation Dose and Imaging
- Head and Neck Surgical Oncology
- Surgical Simulation and Training
- Medical Imaging Techniques and Applications
- Metabolism and Genetic Disorders
- Venous Thromboembolism Diagnosis and Management
University Hospital of Bern
2012-2022
University of Zurich
2006-2020
University of Bern
2012-2018
Medical University of Vienna
2015
A system for robotic cochlear implantation (rCI) has been developed and a corresponding surgical workflow described. The clinical feasibility was demonstrated through the conduction of safe effective rCI procedure.To define demonstrate its feasibility, safety, effectiveness within setting.A use previously described image guided robot developed. Based on pre-operative images, drilling tunnel targeting round window planned drilled by system. Intra-operatively drill path assessed using imaging...
The aim of this study was to compare quantitative and semiquantitative parameters (signal-to-noise ratio [SNR], contrast-to-noise [CNR], image quality, diagnostic confidence) from a standard brain magnetic resonance imaging examination encompassing common neurological disorders such as demyelinating disease, gliomas, cerebrovascular epilepsy, with comparable sequence protocols acquisition times at 3 T 7 T.Ten healthy volunteers 4 subgroups 40 patients in total underwent diffusion-weighted...
Abstract Segmentation of white matter lesions and deep grey structures is an important task in the quantification magnetic resonance imaging multiple sclerosis. In this paper we explore segmentation solutions based on convolutional neural networks (CNNs) for providing fast, reliable segmentations grey-matter multi-modal MR imaging, performance these methods when applied to out-of-centre data. We trained two state-of-the-art fully CNN architectures 2016 MSSEG training dataset, which was...
The detection of new or enlarged white-matter lesions is a vital task in the monitoring patients undergoing disease-modifying treatment for multiple sclerosis. However, definition ‘new enlarged’ not fixed, and it known that lesion-counting highly subjective, with high degree inter- intra-rater variability. Automated methods lesion quantification, if accurate enough, hold potential to make consistent repeatable. majority segmentation algorithms are evaluated their ability separate...
<h3>BACKGROUND AND PURPOSE:</h3> The prevalence and clinical importance of primarily fragmented thrombi in patients with acute ischemic stroke remains elusive. Whole-brain SWI was used to detect multiple thrombus fragments, their significance analyzed. <h3>MATERIALS METHODS:</h3> Pretreatment analyzed for the presence a single intracranial or thrombi. Associations baseline characteristics, complications, outcome were studied. <h3>RESULTS:</h3> Single detected 300 (92.6%), thrombi, 24 324...
Susceptibility-weighted imaging (SWI) enables visualization of thrombotic material in acute ischemic stroke. We aimed to validate the accuracy thrombus depiction on SWI compared time-of-flight MRA (TOF-MRA), first-pass gadolinium-enhanced (GE-MRA) and digital subtraction angiography (DSA). Furthermore, we analysed impact length reperfusion success with endovascular therapy.Consecutive patients stroke due middle cerebral artery (MCA) occlusions undergoing recanalization were screened. Only a...
Image-guided microsurgery requires accuracies an order of magnitude higher than today's navigation systems provide. A critical step toward the achievement such low-error requirements is a highly accurate and verified patient-to-image registration. With aim reducing target registration error to level that would facilitate use image-guided robotic on rigid anatomy head, we have developed semiautomatic fiducial detection technique. Automatic force-controlled localization fiducials patient...
Background Epilepsy surgery is a potentially curative treatment option for pharmacoresistent patients. If non-invasive methods alone do not allow to delineate the epileptogenic brain areas surgical candidates undergo long-term monitoring with intracranial EEG. Visual EEG analysis then used identify seizure onset zone targeted resection as standard procedure. Methods Despite of its great potential assess epileptogenicty tissue, quantitative has yet found way into routine clinical practice. To...
Diagnostic tools to show emboli reliably and protection techniques against embolization when employing stent retrievers are necessary improve endovascular stroke therapy. The aim of the present study was investigate iatrogenic using susceptibility-weighted imaging (SWI) in an open series patients who had been treated with retriever thrombectomy techniques.Patients anterior circulation examined MRI before after were assessed for embolic events. Thrombectomy performed flow arrest under...
Temporal lobe epilepsy (TLE) is the most frequent form of focal in adults. Because approximately half these patients develop drug resistance, surgery designed to remove epileptogenic zone an excellent option selected patients. Histopathological analyses hippocampal specimens TLE revealed 4 types Ammon's horn sclerosis, which are correlated with long-term epileptological outcome. The aim this study was correlation noninvasive, high-resolution, morphological magnetic resonance imaging (MRI) at...
Delivering cochlear implants through a minimally invasive tunnel (1.8 mm in diameter) from the mastoid surface to inner ear is referred as direct access (DCA). Based on cone beam well micro-computed tomography imaging, this vitro study evaluates feasibility and efficacy of manual electrode array insertions via DCA. Free-fitting arrays were inserted 8 temporal bone specimens with previously drilled DCA tunnels. The insertion depth angle, procedural time, alignment scala intracochlear trauma...
The primary aim of this study was to ascertain the prevalence individual conditions and associated anomalies in fetuses with prenatal diagnosis enlarged posterior fossa (PF) explore diagnostic accuracy ultrasound these anomalies. secondary evaluate postnatal outcome children affected by PF anomalies.All detected sonography at a referral center from 2001 2015 were analyzed retrospectively. Some also studied fetal magnetic resonance imaging (MRI) or volume examinations. Fetal sonographic MRI...
The aim of this study was to compare the relationship between core executive functions and frontoparietal network connections at rest children who had suffered an arterial ischemic stroke typically developing peers. Children diagnosed with more than two years previously controls were included. Executive function (EF) measures comprised inhibition (Go-NoGo task), fluency (category processing speed (processing tasks), divided attention, working memory (letter-number sequencing), conceptual...
Although chronic pelvic pain syndrome impairs the life of millions people worldwide, exact pathomechanisms involved remain to be elucidated. As with other syndromes, central nervous system may have an important role in syndrome. Thus, we assessed brain alterations associated abnormal processing patients syndrome.Using morphology assessment applying structural magnetic resonance imaging, prospectively investigated a consecutive series 20 men refractory syndrome, and compared these gender age...
Objective To assess the efficacy and safety of sono-electro-magnetic therapy compared to placebo in men with refractory CPPS. Patients Methods In a randomized, placebo-controlled, double-blind single center trial, we assessed effect treatment Sixty male patients were randomly assigned either (n = 30) or for 12 weeks. The primary outcome was change National Institutes Health Chronic Prostatitis Symptom Index (NIH-CPSI) from baseline Results 12-week difference between changes NIH-CPSI total...
Descriptive statistics with respect to patient anatomy and image guidance accuracy can be used assess the effectiveness of any system for minimally invasive cochlear implantation, on both an individual wider population level.Minimally implantation involves drilling a tunnel from surface mastoid cochlea, trajectory passing through facial recess. The recess constrains path places prohibitive requirements system. Existing single thresholds are insufficient assessing these systems.A statistical...