A5028116331- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Pituitary Gland Disorders and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiac, Anesthesia and Surgical Outcomes
- Vascular Malformations Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Acute Ischemic Stroke Management
- Meningioma and schwannoma management
- Cerebrospinal fluid and hydrocephalus
- Nerve injury and regeneration
- Moyamoya disease diagnosis and treatment
- Aortic aneurysm repair treatments
- Neurogenesis and neuroplasticity mechanisms
- Surgical Simulation and Training
- Anatomy and Medical Technology
- Spinal Fractures and Fixation Techniques
- Augmented Reality Applications
- Glioma Diagnosis and Treatment
- Trigeminal Neuralgia and Treatments
- Head and Neck Surgical Oncology
- Anesthesia and Neurotoxicity Research
University of Bern
2015-2025
Kantonsspital Aarau
2018-2025
University Hospital of Bern
2015-2025
Swiss Continence Foundation
2012-2021
University of Pittsburgh
2021
GTx (United States)
2020
Boston Children's Hospital
2014-2018
Harvard University
2014-2018
University Children’s Hospital Bern
2017
Complete resection of contrast-enhancing tumor has been recognized as an important prognostic factor in patients with glioblastoma and is a primary goal surgery. Various intraoperative technologies have recently introduced to improve glioma surgery.To evaluate the impact using 5-aminolevulinic acid mapping monitoring on rate complete enhancing (CRET), gross total (GTR), new neurological deficits part institutional protocol.One hundred three consecutive underwent from August 2008 November...
Significance The inability of CNS pathways to regenerate after injury can lead devastating, life-long losses in sensory, motor, and other functions. We report that the optic nerve, a widely studied pathway normally cannot regenerate, mobile zinc (Zn 2+ ) increases rapidly processes retinal interneurons (amacrine cells) then transfers via vesicular release ganglion cells (RGCs), injured projection neurons. Eliminating Zn leads both persistent RGC survival substantial axon regeneration with...
The clinical image illustrates an unusual case of a patient with bilateral carotid artery dissection caused by compression from elongated styloid processes. In this case, the diagnosis was overlooked eight years earlier. Eagle's syndrome, marked process, can result in cervical dissection, highlighting significance recognizing correlation recurrent cases, which occur more frequently than idiopathic ICA dissections.
Abstract Recent trends in first-line transsphenoidal surgery (TSS) for prolactinoma patients aim to reduce long-term dependence on dopamine agonists (DA). Key factors linked poor surgical outcomes include cavernous sinus invasiveness and high baseline serum prolactin (PRL) levels. Defining simple PRL threshold values indicate inform treatment strategy is crucial. In this retrospective cohort study of 149 treated with or agonist (DA) therapy, we evaluated preoperative levels invasion as...
The etiology of chronic subdural hematoma (CSDH) in nongeriatric patients (≤ 60 years old) often remains unclear. primary objective this study was to identify spinal CSF leaks young patients, after formulating the hypothesis that are causally related CSDH.All consecutive age or younger who underwent operations for CSDH between September 2009 and April 2011 at Bern University Hospital were included prospective cohort study. patient workup an extended search a leak using systematic algorithm:...
In clinical practice, the size of adenomas is crucial for guiding prolactinoma patients towards most suitable initial treatment. Consequently, establishing guidelines serum prolactin level thresholds to assess essential. However, potential impact gender differences in levels on estimating adenoma (micro- vs. macroadenoma) not yet fully comprehended.
Abstract Context Although consensus guidelines recommend dopamine agonists (DAs) as the first-line approach in prolactinomas, some patients may opt instead for upfront surgery, with goal of minimizing need continuation DAs over long term. While this can be recommended selected a microprolactinoma, indication surgery macroprolactinomas remains controversial, limited long-term data large cohorts. We aimed at elucidating whether is equally safe and effective micro- or not extending beyond...
BACKGROUND: Postoperative pain management is key for patient satisfaction. Pressure threshold (PPT) has been studied in some surgical cohorts but not relationship to acute postoperative short-stay patients undergoing anorectal surgery. We hypothesized that preoperative finger PPT measurements can identify respective with higher pain. Aiming understand the subjective perception, we tested hypotheses associated Visual Analog Scale (VAS) scores and correlates analgesic consumption METHODS:...
Background and Purpose: Endovascular aneurysm treatment relies on a biological process, including cell migration for thrombus organization growth of neointima. To better understand healing, our study explores the origin neointima-forming thrombus-organizing cells in rat saccular sidewall model. Methods: Saccular aneurysms were transplanted onto abdominal aorta male Lewis rats endovascularly treated with coils (n=28) or stents (n=26). In 34 cases, GFP+ (green fluorescent protein)-expressing...
<h3>BACKGROUND AND PURPOSE:</h3> For patients with cerebral vasospasm refractory to medical and hemodynamic therapies, endovascular therapies often remain the last resort. Data from studies in large cohorts on efficacy safety of multiple immediate interventions are sparse. Our aim was assess feasibility repeat instant medical, hemodynamic, initial interventions. <h3>MATERIALS METHODS:</h3> This a single-center retrospective study prospectively collected data requiring ≥3 during course...
Craniopharyngioma-related hypothalamic obesity is a devastating complication with limited data on whether long-term follow-up should focus problems other than endocrine deficiencies and weight gain. The primary endpoint was the assessment of predictors development; secondary functional outcome (endocrine deficiencies, visual acuity) at follow-up.This retrospective case-note study examined craniopharyngioma patients least 2 years follow-up. Clinical, radiological biochemical characteristics...
OBJECTIVEDexamethasone, a known regulator of mesenchymal programming in glioblastoma (GBM), is routinely used to manage edema GBM patients. Dexamethasone also activates the expression genes, such as CEBPB, stem cells (GSCs). However, drug's impact on invasion, proliferation, and angiogenesis remains unclear. To determine whether dexamethasone induces GBM, authors investigated vitro, vivo, clinical information derived from The Cancer Genome Atlas (TCGA) cohort.METHODSExpression profiles...