A5066654445- Multiple Sclerosis Research Studies
- Polyomavirus and related diseases
- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- SARS-CoV-2 and COVID-19 Research
- Systemic Lupus Erythematosus Research
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Peripheral Neuropathies and Disorders
- Immunotherapy and Immune Responses
- Rheumatoid Arthritis Research and Therapies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Systemic Sclerosis and Related Diseases
- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Neurological Disorders and Treatments
- Autoimmune Neurological Disorders and Treatments
- Genetic Neurodegenerative Diseases
- Family Support in Illness
- Vasculitis and related conditions
- Glioma Diagnosis and Treatment
- Peripheral Artery Disease Management
- Sleep and related disorders
- Otitis Media and Relapsing Polychondritis
- Vestibular and auditory disorders
University Hospital of Bern
2021-2025
University of Bern
2021-2025
Medical University of Vienna
2021-2024
Universität Innsbruck
2024
Semaglutide, a GLP-1 receptor agonist widely prescribed for type 2 diabetes and obesity, has recently raised concerns about its ocular safety. This study aimed to investigate the association between semaglutide use vision impairment using data from FDA Adverse Event Reporting System (FAERS). We conducted an analysis of FAERS data, comparing reports associated with those other antidiabetic weight loss medications. The main outcome measure was reporting odds ratio (rOR) linked compared...
Introduction Post-COVID-19 syndrome affects approximately 10-25% of people suffering from COVID-19 infection, irrespective initial severity. Fatigue is one the major symptoms, occurring in 30-90% with post-COVID-19 syndrome. This study aims at describing factors associated fatigue seen our newly established Post-Covid clinic. Methods retrospective single center included 42 consecutive patients treated Department Neurology, University Hospital Bern, between 11/2020 and05/2021. Clinical...
Post-COVID-19 syndrome affects approximately 10-25% of people after a COVID-19 infection, irrespective initial severity. The aim this project was to assess the clinical characteristics, course, and prognosis post-COVID-19 using systematic multidimensional approach.An online survey with suspected confirmed syndrome, distributed via Swiss support groups, social media, our consultation, performed. A total 8 post-infectious domains were assessed 120 questions. Data collected from October 15...
BackgroundOcrelizumab (OCR) is a humanized monoclonal antibody directed against CD-20 positive lymphocytes, mainly B-lymphocytes. OCR approved for treatment of primary progressive (PPMS) and relapsing multiple sclerosis (RMS). This study aims to provide real-world safety efficacy data people with RMS treated in two Swiss Multiple Sclerosis (MS) centers.MethodsWe have conducted retrospective analysis using the patient cohorts from Cantonal Hospital Aarau Bern University (RMS: n=235)....
Isolated value of MRI metrics in relapsing multiple sclerosis (RMS) as a surrogate marker response to disease-modifying treatment (DMT) and, thus, decision criteria for DMT escalation the absence clinical signs disease activity is still matter debate. The aim this study was investigate whether based on isolated affects outcome. Combining data from 5 MS centers Austria and Switzerland, we included patients with RMS aged at least 18 years who (1) had initiated first-line,...
Sleep–wake disturbances are common in post-COVID-19 syndrome but lack extensive objective characterization. This study evaluated sleep–wake patterns 31 patients with referred for fatigue and excessive daytime sleepiness (EDS). Assessments included questionnaires (the severity scale, the Epworth Beck Depression Index-II), video polysomnography (V-PSG), multiple sleep latency test (MSLT, n = 15), actigraphy (n 29). Patients (70% female, mean age 45 years) had mostly mild acute SARS-CoV-2...
We present a case of paraneoplastic tumefactive demyelination in 55-year-old female with an underlying anaplastic thyroid carcinoma (ATC), alongside review the literature on all cases associated non-CNS neoplasia. In presented patient developed right-sided subacute sensorimotor hemiparesis. The initial cerebral MRI revealed bilateral frontoparietal mass lesion marked gadolinium uptake and effect. Cerebrospinal fluid CSF-specific oligoclonal bands type III, negative cell count, protein...
Background: Leptomeningeal inflammation in patients with multiple sclerosis (MS) mainly affects meningeal B-cell follicle-like structures linked to cortical and subpial lesions can be visualized as leptomeningeal enhancement (LME). Objective: To evaluate the evolution of LME under different MS immunotherapies. Methods: A total 214 treated anti-CD20 therapies or fingolimod at university hospital Bern were screened for LME. Magnetic resonance imaging (MRI) medical records retrospectively...
The aim of this study was to investigate baseline characteristics and outcome patients after endovascular therapy (EVT) for acute large vessel occlusion (LVO) in relation their history symptomatic vascular disease sex.
Abstract Objective To investigate the impact of transition interval length when switching from natalizumab (NTZ) to anti‐CD20 monoclonal antibodies (antiCD20) on recurrent disease activity and safety in relapsing multiple sclerosis (RMS). Methods Aggregating data 8 MS centres Austria, Switzerland, Germany, we included RMS patients who (i) continuously received NTZ for ≥3 months, (ii) were switched antiCD20, (iii) had ≥12 months follow‐up after switch. The primary endpoint was occurrence...
Introduction Patients with Multiple Sclerosis (pwMS) treated anti-CD20 (cluster of differentiation) monoclonal antibodies (mAbs) such as ocrelizumab (OCR) and ofatumumab (OFA) show a reduction mainly B-lymphocytes, but also other lymphocyte subsets can be affected by these treatments. There is limited data on differences between subset counts pwMS after treatment initiation OCR or OFA. Objective To compare in Methods We analyzed 22 initiated OFA 56 sex-, age- MS course matched from 2...
Relapse presentation in relapsing multiple sclerosis (RMS) differs between sexes, leading to differential outcomes. An influence of age seems likely but is less well investigated separately for women and men.
Objective: Anti-CD20-treated patients are at risk of a reduced humoral immune response during the SARS-CoV-2 pandemic. Our aim was to compare antibody after two vaccinations with mRNA vaccines BNT162b2 or mRNA-1273 in multiple sclerosis. Methods: Data from University Hospital Bern and Cantonal Lucerne were retrospectively collected medical records then analyzed. Anti-spike IgG serum titers both centers considered be protective value ≥100 AU/mL. Continuous variables given as mean 95%...
Fatigue is one of the most disabling and difficult to treat symptoms autoimmune diseases frequently presents in people with multiple sclerosis (PwMS). Hypogammaglobulinemia for immunoglobulin G (IgG) affects approximately 8-25% PwMS. We performed a retrospective analysis investigate association MS-fatigue IgG hypogammaglobulinemia.PwMS, treated at Eginition University Hospital Athens or Bern, were included (n = 134 patients (Bern n 99; 35)). Mann Whitney U-test (MWT), ANOVA test, Chi2 test...
Background: Reporting of sex-specific analyses in multiple sclerosis (MS) is sparse. Disability accrual results from relapses (relapse-associated worsening) and independent thereof (progression relapses). Objectives: A population MS patients during relapse treated per standard care was analyzed for sex differences short-term outcome (3–6 months) as measured by Expanded Status Scale (EDSS) change. Design: Single-center retrospective study. Methods: We 134 between March 2016 August 2020. All...
The differences in vascular risk factors' and stroke burden across Europe are notable, however there is limited understanding of the influence socioeconomic environment on quality secondary prevention outcome after acute ischemic stroke.
A large number of disease-modifying immunotherapies are available for the treatment people with multiple sclerosis. Many show scarce or no safety data in pregnancy and breastfeeding labeled as being contraindicated during these periods Swiss summary product characteristics. Some also have restrictions male patients. Hence, family planning should always be considered decisions. If clinically necessary, continuation immunotherapy can some substances. In situations, “Good Off-Label Use...
Zusammenfassung. Ungesunde Ernährung ist einer der modifizierbaren Risikofaktoren für die Entstehung von Hirnschlägen. Dennoch zeigt sich weltweit eine suboptimale Ernährung. Lebensmittel wie Süssgetränke, verarbeitete Fleischprodukte und salzreiche Nahrungsmittel werden im Übermass konsumiert; gesunde Vollkornprodukte nährstoffreiche Nahrung Gemüse, Früchte Fisch zu wenig. Dies trifft auch auf Schweiz zu. Wir fassen hier in diesem Artikel Erkenntnisse über den Einfluss das Hirnschlagrisiko...