A5018676005- Long-Term Effects of COVID-19
- Trigeminal Neuralgia and Treatments
- Neurosurgical Procedures and Complications
- Cerebral Venous Sinus Thrombosis
- Glioma Diagnosis and Treatment
- Olfactory and Sensory Function Studies
- Spine and Intervertebral Disc Pathology
- Migraine and Headache Studies
- Ophthalmology and Eye Disorders
- Meningioma and schwannoma management
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological and metabolic disorders
- Multiple Sclerosis Research Studies
- Spinal Fractures and Fixation Techniques
- RNA regulation and disease
- Tuberous Sclerosis Complex Research
- Musculoskeletal synovial abnormalities and treatments
- Medical Imaging and Pathology Studies
- Lysosomal Storage Disorders Research
- Pituitary Gland Disorders and Treatments
- COVID-19 and Mental Health
- Advanced MRI Techniques and Applications
- Glycogen Storage Diseases and Myoclonus
- Syphilis Diagnosis and Treatment
- Alzheimer's disease research and treatments
Hospital Clínico San Carlos
2016-2025
Universidad Complutense de Madrid
2002-2025
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2017-2022
Althaia
2007
Hospital Regional Universitario de Málaga
1991
Brain changes have been reported in the first weeks after SARS-CoV-2 infection. However, limited literature exists about brain alterations post-COVID syndrome, a condition increasingly associated with cognitive impairment. The present study aimed to evaluate functional and structural patients assess whether these were related dysfunction. Eighty-six syndrome 36 healthy controls recruited underwent neuroimaging acquisition comprehensive neuropsychological assessment. Cognitive examinations...
Olfactory dysfunction is common during SARS-CoV-2 infection. The pathophysiology of the persistence this symptom and potential relationship with central nervous system involvement unknown.To evaluate neural correlates persistent olfactory in a series patients post-COVID syndrome.Eighty-two syndrome were assessed Brief Smell Identification Test multimodal MRI study including 3D-T1, T2-FLAIR, diffusion-tensor imaging, arterial spin labeling. neuroimaging examinations performed 11.18 ± 3.78...
Cognitive deficits are among the main disabling symptoms in COVID-19 patients and post-COVID syndrome (PCS). Within brain regions, hippocampus, a key region for cognition, has shown vulnerability to SARS-CoV-2 infection. Therefore, vivo detailed evaluation of hippocampal changes PCS patients, validated on post-mortem samples at acute phase, would shed light into relationship between cognition.Hippocampal subfields volume, microstructure, perfusion were evaluated 84 compared 33 controls....
Objective: Cognitive impairment is an important feature in multiple sclerosis (MS) and has been associated to several Magnetic Resonance Imaging (MRI) markers, but especially brain atrophy. However, the relationship between specific neuropsychological tests examining cognitive functions volumes little explored. Furthermore, because MS frequently damage subcortical regions, it may be interesting model examine role of areas functioning. Our aim was identify correlations regions performance...
<h3>Objectives</h3> To assess the efficacy of a single intradiscal injection allogeneic bone marrow mesenchymal stromal cells (BM-MSCs) versus sham placebo in patients with chronic low back pain (LBP). <h3>Methods</h3> Participants were randomised prospective, double-blind, controlled study to receive either or 20 million BM-MSC, between April 2018 and December 2022. The first co-primary endpoint was rate responders defined by improvement Visual Analogue Scale (VAS) for at least 20% mm,...
Abstract Introduction Natalizumab ( NTZ ) is an effective drug for the treatment of relapsing‐remitting multiple sclerosis. In some patients discontinuation mandatory due to risk progressive multifocal leukoencephalopathy. However, severe clinical and radiological worsening has been described after cessation. Our aim was describe features rebound phenomenon. Material Methods Patients switched from Fingolimod FTY who had presented a were selected. Clinical magnetic resonance imaging MRI data...
Our objective was to evaluate use of gadolinium-enhanced three-dimensional (3D) MR angiography in the assessment suspected arterial inflow stenosis after kidney transplantation.Twenty-eight consecutive patients receiving transplants (26 single-kidney and two en block transplants) with were examined sequences: 3D fast spoiled gradient-recalled (SPGR) imaging phase-contrast imaging. Twenty-four these then using gold standards: either digital subtraction (DSA) (n = 23) or surgery 1). DSA...
Spinal ependymoma is a benign central nervous system tumor described as an intramedullary lesion more frequently located at the conus medullaris. It has been exceptionally in literature intradural extramedullary tumor.Presentation of extremelly rare location and evolution extremedullary discussion its probable origin, differential diagnosis, treatment options, follow-up.This case demonstrates unusual ependymal space with total resection, which recurred lower level malignant transformation...
The Paced Auditory Serial Addition Test (PASAT) is a useful cognitive test in patients with multiple sclerosis (MS), assessing sustained attention and information processing speed. However, the neural underpinnings of performance are controversial. We aimed to study basis PASAT by using structural magnetic resonance imaging (MRI) series 242 MS. (3-s) was administered together comprehensive neuropsychological battery. Global brain volumes total T2-weighted lesion were estimated. Voxel-based...
Trigeminal neuralgia is most commonly caused by vascular compression at the trigeminal nerve (TN) root entry zone. Microvascular decompression (MVD) has been established as a useful treatment. Outcome depends on correct identification of site and its adequate surgery. Preoperative neurovascular might predict which patients will benefit from MVD. Management persistent or recurrent after an MVD baffling problem for neurosurgeons. An accurate neuroradiological evaluation TN padding following...
Multicenter, prospective, randomized, and double-blinded study.To compare tubular endoscopic interlaminar approach.Patients with lumbar spinal stenosis neurogenic claudication of were randomized to or technique. Enrollment period was 12 months. Clinical follow up at 1, 3, 6 months after surgery visual analogue scale (VAS), Oswestry Disability Index (ODI), Japanese Orthopedic Association (JOA) score. Radiologic evaluation magnetic resonance pre- postsurgery.Twenty patients enrolled: 10 in...
RATIONAL AND AIM: to better understand the nature of consults solicited by Department General Surgery Internal Medicine and examine results experience from point view an specialist.Prospective analysis 129 patients admitted in Medi-cine during 2005.The number was 4% all (6,5% de were emergency service 2% planning programme). The median age 74 years. visited a mean 3.3 days. most frequent reasons for consultation dyspnea (29%), fever (21%), cough (11%) dysrhythmias (8%). diagnosis cardiac...
Medical treatment of meningiomas is reserved for cases in which surgery and radiotherapy have failed. Given that a high percentage express somatostatin receptors, with analogues has been proposed. In addition, these medications shown to an antiproliferative antiangiogenic effect vitro. To date, very few clinical response none radiological described. The case described here the first report response. A 76-year-old Caucasian male was diagnosed unresectable meningioma at age 47. patient...
Spontaneous intracranial hypotension (SIH) is a well-documented syndrome characterized typically by benign, self-limited course. Patients present with postural or exertional headaches that can be temporarily relieved lying in supine recumbent position. A 35-year-old Caucasian male suffered orthostatic headache developed to bilateral abducens palsy. We ordered relative rest and the patient improved completely recovered after 3 months. Although SIH considered as benign self limited process it...
The prognostic capacity of the diffusion tensor imaging measures fractional anisotropy (FA) and mean diffusivity (MD) to detect mild cognitive impairment (MCI) progression Alzheimer's disease (AD) was assessed in 135 MCI patients 72 healthy subjects over a median follow-up 40 months. Forty-nine (36.3%) developed AD. factors MD left hippocampus, FA cingulate, hippocampus emerged as predictors progression. Age (hazard ratio [HR] 1.21), delayed text recall (HR 0.89), uncinate 1.90), 2.21),...