Mareike Wendorff
A5012632196- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- vaccines and immunoinformatics approaches
- T-cell and B-cell Immunology
- SARS-CoV-2 and COVID-19 Research
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Liver Disease Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Genetic Associations and Epidemiology
- Genomics and Phylogenetic Studies
- Genetics and Neurodevelopmental Disorders
- Hemoglobinopathies and Related Disorders
- Atherosclerosis and Cardiovascular Diseases
- Machine Learning in Bioinformatics
- Dermatology and Skin Diseases
- Cardiovascular Disease and Adiposity
- Single-cell and spatial transcriptomics
- Psoriasis: Treatment and Pathogenesis
- Systemic Lupus Erythematosus Research
- Viral-associated cancers and disorders
- Phagocytosis and Immune Regulation
- IL-33, ST2, and ILC Pathways
- Blood groups and transfusion
- interferon and immune responses
Leibniz Institute for Science and Mathematics Education
2023-2024
Kiel University
2018-2023
Biogipuzkoa Health Research Institute
2020
There is considerable variation in disease behavior among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes 2019 (Covid-19). Genomewide association analysis may allow for identification of potential genetic factors involved development Covid-19.
The number of applications deep learning algorithms in bioinformatics is increasing as they usually achieve superior performance over classical approaches, especially, when bigger training datasets are available. In applications, discrete data, e.g. words or n-grams language, amino acids nucleotides bioinformatics, generally represented a continuous vector through an embedding matrix. Recently, this matrix directly from the data part iteration model to optimize target prediction - process...
Natural killer (NK) cells are innate immune that contribute to host defense against virus infections. NK respond severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro and activated patients with disease 2019 (COVID-19). However, by which mechanisms detect SARS-CoV-2-infected remains largely unknown. Here, we show the Non-structural protein 13 of SARS-CoV-2 encodes for a peptide is presented human leukocyte antigen E (HLA-E). In contrast self-peptides, viral prevents binding...
Objective One of the current hypotheses to explain proinflammatory immune response in IBD is a dysregulated T cell reaction yet unknown intestinal antigens. As such, it may be possible identify disease-associated clonotypes by analysing peripheral and T-cell receptor (TCR) repertoire patients with controls. Design We performed bulk TCR profiling both alpha beta chains using high-throughput sequencing blood samples total 244 healthy controls as well from matched tissue 59 disease further...
ABSTRACT Background Respiratory failure is a key feature of severe Covid-19 and critical driver mortality, but for reasons poorly defined affects less than 10% SARS-CoV-2 infected patients. Methods We included 1,980 patients with respiratory at seven centers in the Italian Spanish epicenters pandemic Europe (Milan, Monza, Madrid, San Sebastian Barcelona) genome-wide association analysis. After quality control exclusion population outliers, 835 1,255 population-derived controls from Italy,...
Genotype imputation of the human leukocyte antigen (HLA) region is a cost-effective means to infer classical HLA alleles from inexpensive and dense SNP array data. In research setting, helps avoid costs for wet lab-based typing thus renders association analyses in large cohorts feasible. Yet, most reference panels target Caucasian ethnicities multi-ethnic are scarce. We compiled high-quality panel based on genotypes measured with Illumina's Immunochip genotyping types established using...
Abstract Autoimmune neurological syndromes (AINS) with autoantibodies against the 65 kDa isoform of glutamic acid decarboxylase (GAD65) present limbic encephalitis, including temporal lobe seizures or epilepsy, cerebellitis ataxia, and stiff-person-syndrome overlap forms. Anti-GAD65 are also detected in autoimmune diabetes mellitus, which has a strong genetic susceptibility conferred by human leukocyte antigen (HLA) non-HLA genomic regions. We investigated predisposition patients anti-GAD65...
Abstract Inflammatory bowel disease (IBD) is a chronic inflammatory of the gut. Genetic association studies have identified highly variable human leukocyte antigen (HLA) region as strongest susceptibility locus for IBD and specifically DRB1*01:03 determining factor ulcerative colitis (UC). However, most signal such delineation could not be made because tight structures linkage disequilibrium within HLA. The aim this study was therefore to further characterize HLA using transethnic approach....
Abstract Psoriasis is a chronic inflammatory disorder of the skin, with genetic factors reportedly involved in disease pathogenesis. Numerous studies reported psoriasis candidate genes. However, these tend to involve mostly European and Asian populations. Here, we report first genome‐wide association study ( GWAS ) an Egyptian population, identifying susceptibility variants for using two‐stage case‐control design. In discovery stage, carried out analysis Infinium ® Global Screening Array‐24...
Human Leukocyte Antigen class II (HLA-II) molecules present peptides to T lymphocytes and play an important role in adaptive immune responses. Characterizing the binding specificity of single HLA-II has profound impacts for understanding cellular immunity, identifying cause autoimmune diseases, immunotherapeutics, vaccine development. Here, novel high-density peptide microarray technology combined with machine learning techniques were used address this task at unprecedented level...
ABSTRACT Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis host genetic contribution to severe COVID-19 is important improve our understanding underlying mechanisms. Here, we describe an extended GWAS meta-analysis well-characterized cohort 3,260 patients with respiratory failure and 12,483 population controls from Italy, Spain, Norway Germany/Austria, including stratified analyses based on age, sex severity, as well targeted chromosome Y...
Abstract Motivation The ability to generate sample-specific protein sequences is a crucial step in neo-antigen discovery, cancer vaccine development, and proteogenomics. revolutionary increase the throughput of sequencers has fueled large-scale genomic transcriptomic studies, holding great promises for emerging field personalized medicine. However, most sequencing projects store their data an abbreviated variant calling format (VCF) that not immediately amenable subsequent proteomic...
Abstract Background The human leukocyte antigen (HLA) proteins play a fundamental role in the adaptive immune system as they present peptides to T cells. Mass-spectrometry-based immunopeptidomics is promising and powerful tool for characterizing immunopeptidomic landscape of HLA proteins, that presented on proteins. Despite growing interest technology, recent rise immunopeptidomics-specific identification pipelines, there still gap data-analysis software tools are specialized analyzing...
ABSTRACT The human leukocyte antigen (HLA) class II proteins present peptides to CD4 + T cells through an interaction with cell receptors (TCRs). Thus, HLA are key players in shaping immunogenicity and immunodominance. Nevertheless, factors governing peptide presentation by HLA-II still poorly understood. To address this problem, we profiled the blood transcriptome immunopeptidome of 20 healthy individuals integrated profiles publicly available immunopeptidomics datasets. In depth...
ABSTRACT Inflammatory bowel disease (IBD) is a chronic inflammatory of the gut. Genetic association studies have identified highly variable human leukocyte antigen (HLA) region as strongest susceptibility locus for IBD, and specifically DRB1*01:03 determining factor ulcerative colitis (UC). However, most signal such delineation could not be made due to tight structures linkage disequilibrium within HLA. The aim this study was therefore further characterize HLA using trans-ethnic approach. We...
Abstract Genome wide association studies contributed to a better understanding of the etiology inflammatory bowel disease (IBD). While over 240 genetic associations with IBD have since been identified, functional follow-up are still in their infancy overall pathogenesis remaining unsolved. E.g., between human leukocyte antigen (HLA) region and ulcerative colitis (UC) – one subtypes is lacking. Here, we analyzed whether an autoimmune reaction involving HLA class II proteins HLA-DQ -DR, both...