Maria Carrabba
A5027447513- Immunodeficiency and Autoimmune Disorders
- Pneumonia and Respiratory Infections
- SARS-CoV-2 and COVID-19 Research
- Blood disorders and treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Respiratory viral infections research
- Blood groups and transfusion
- Cystic Fibrosis Research Advances
- Inflammasome and immune disorders
- COVID-19 Clinical Research Studies
- Diabetes and associated disorders
- interferon and immune responses
- Immune Cell Function and Interaction
- Nosocomial Infections in ICU
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immune Response and Inflammation
- Chronic Lymphocytic Leukemia Research
- Antimicrobial Resistance in Staphylococcus
- Adolescent and Pediatric Healthcare
- Parvovirus B19 Infection Studies
- Systemic Lupus Erythematosus Research
- Drug-Induced Adverse Reactions
- Gastrointestinal disorders and treatments
- Kawasaki Disease and Coronary Complications
- Spine and Intervertebral Disc Pathology
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2015-2025
Ospedale Maggiore
2005-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2005-2024
University Medical Center Freiburg
2023
University of Freiburg
2023
University of Milan
2005-2022
Weatherford College
2022
University College London
2022
Azienda Ospedaliera Universitaria Pisana
2022
Sapienza University of Rome
2022
There is considerable variation in disease behavior among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes 2019 (Covid-19). Genomewide association analysis may allow for identification of potential genetic factors involved development Covid-19.
Clinical Implications•Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive patients with inborn errors of immunity (IEI) showed a similar infection-fatality rate, lower incidence in pediatric age, and younger age at death than the SARS-CoV-2–positive Italian population. The fatality rate was previously reported from other IEI cohorts. Antibody deficiencies long-lasting SARS-CoV-2 positivity. •Severe Early reports described an unexpected low number affected by severe...
BackgroundLacking protective antibodies, patients with primary antibody deficiencies (PADs) experience frequent respiratory tract infections, leading to chronic pulmonary damage. Macrolide prophylaxis has proved effective in diseases.ObjectiveWe aimed test the efficacy and safety of orally administered low-dose azithromycin PADs.MethodsWe designed a 3-year, double-blind, placebo-controlled, randomized clinical trial whether oral (250 mg once daily 3 times week for 2 years) would reduce...
ABSTRACT Background Respiratory failure is a key feature of severe Covid-19 and critical driver mortality, but for reasons poorly defined affects less than 10% SARS-CoV-2 infected patients. Methods We included 1,980 patients with respiratory at seven centers in the Italian Spanish epicenters pandemic Europe (Milan, Monza, Madrid, San Sebastian Barcelona) genome-wide association analysis. After quality control exclusion population outliers, 835 1,255 population-derived controls from Italy,...
COVID-19 manifestations range from asymptomatic to life-threatening infections. The outcome in different inborn errors of immunity (IEI) is still a matter debate. In this retrospective study, we describe the experience Italian Primary Immunodeficiencies Network (IPINet). Sixteen reference centers for adult or pediatric IEI were involved. One hundred fourteen patients enrolled including 35 and 79 patients. Median age was 32 years, male-to-female ratio 1.5:1. most common 22q11.2 deletion...
Background: Granulomatous and Lymphocytic Interstitial Lung Diseases (GLILD) is a severe non-infectious complication of Common Variable Immunodeficiency (CVID), often associated with extrapulmonary involvement. Due to poorly understood pathogenesis, GLILD diagnosis management criteria still lack consensus. Accordingly, it relevant cause long-term loss respiratory function closely markedly reduced survival. The aim this study was describe clinical, immunological, laboratory functional...
The study compares the ability of PSI (pneumonia severity index), CURB-65 (confusion, urea >7 mol·L −1 , respiratory rate ≥30 breaths·min blood pressure <90 mmHg systolic or ≤60 diastolic, and age ≥65 yrs), CURB CRB-65 scales Severe Community-Acquired Pneumonia (SCAP) score to predict 30-day mortality in healthcare-associated pneumonia (HCAP) patients, analyses differences demographics, aetiology outcomes community-acquired (CAP), HCAP immunocompromised patients. 629 consecutive...
Abstract Background Due to the absence of curative treatments for inborn errors immunity (IEI), children born with IEI require long-term follow-up disease manifestations and related complications that occur over lifespan. Effective transition from pediatric adult services is known significantly improve adherence treatment outcomes. It currently not what are available young people in Europe. Objective To understand prevalence practice Europe IEI, encompassing both primary immunodeficiencies...
Job's syndrome, or autosomal dominant hyperimmunoglobulin E syndrome (AD-HIES, STAT3-Dominant Negative), is a rare inborn error of immunity (IEI) with multi-organ involvement and long-life post-infective damage. Longitudinal registries are primary importance in improving our knowledge the natural history management these disorders. This study aimed to describe 30 Italian patients AD-HIES recorded network for immunodeficiency (IPINet) registry. shows incidence manifestations present at time...
Background High throughput sequencing techniques are very effective tools to achieve a timely genetic definition of inborn errors immunity (IEIs). However, they often reveal variants uncertain significance (VUS), and in some cases, the identification causative alteration may be hampered by technical issues. Recent studies suggest that genome-wide DNA methylation profiling on blood samples represent an tool for reassessing pathogenic role VUS defined set disease-causing genes increase...
The primary aim of this study is to investigate the evolution clinical and laboratory characteristics during time in a longitudinal cohort pediatric-onset adult-onset Common Variable Immunodeficiency (CVID) patients order identify early predictive features disease immune dysregulation complications.This retrospective-prospective monocentric spanning from 1984 end 2021. data vs. have been compared for immunological infectious non-infectious complications assessed at diagnosis...
Abstract Background The CDC and ACIP recommend COVID-19 vaccination for patients with inborn errors of immunity (IEI). Not much is known about vaccine safety in IEI, whether attenuates infection severity IEI. Objective To estimate examine effect on outcomes Methods We built a secure registry database conjunction the US Immunodeficiency Network to frequency indicators effectiveness IEI patients. opened January 1, 2022, closed August 19, 2022. Results Physicians entered data 1245 from 24...
Abstract Patient registries are a very important and essential tool for investigating rare diseases, as most physicians only see limited number of cases during their career. Diseases multi-organ autoimmunity autoinflammation especially challenging, they characterized by diverse clinical phenotypes highly variable expressivity. The GAIN consortium (German Auto Immunity Network) developed dataset addressing these challenges. ICD-11, HPO, ATC codes were incorporated to document various...
We assessed the health-related quality of life (HRQoL) in CVID adults receiving different schedules immunoglobulin replacement therapy (IgRT) by intravenous (IVIG), subcutaneous (SCIG), and facilitated (fSCIG) preparations. For these patients, IgRT schedule was chosen after a period focused on identifying most suitable individual option. Three hundred twenty-seven participants were enrolled prospective, observational, 18-month study. Participants received for at least 2 years. The first 6...
Early treatment with remdesivir (RMD) or monoclonal antibodies (mAbs) could be a valuable tool in patients at risk of severe COVID-19 unsatisfactory responses to vaccination. We aim assess the safety and clinical outcomes these treatments among immunocompromised subjects.We retrospectively reviewed all nonhospitalized who received an early RMD mAbs for COVID-19, from 25 November 2021 January 2022, large tertiary hospital. Outcomes included frequency adverse drug reaction (ADR), duration...
Ataxia telangiectasia (AT) is a rare neurodegenerative genetic disorder due to bi-allelic mutations in the Telangiectasia Mutated (ATM) gene. The aim of this paper better define immunological profile over time, clinical immune-related manifestations at diagnosis and during follow-up, attempt genotype-phenotype correlation an Italian cohort AT patients. Retrospective data 69 patients diagnosed between December 1984 November 2019 were collected from database Primary Immunodeficiency Network....