A5050629820- Immunodeficiency and Autoimmune Disorders
- Blood disorders and treatments
- Cytomegalovirus and herpesvirus research
- Asthma and respiratory diseases
- Sinusitis and nasal conditions
- Congenital Ear and Nasal Anomalies
- Allergic Rhinitis and Sensitization
- Immune Cell Function and Interaction
- Dermatology and Skin Diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Nail Diseases and Treatments
- Otitis Media and Relapsing Polychondritis
- SARS-CoV-2 and COVID-19 Research
- Tracheal and airway disorders
- Drug-Induced Adverse Reactions
- Chronic Lymphocytic Leukemia Research
- Contact Dermatitis and Allergies
- Diabetes and associated disorders
- Cystic Fibrosis Research Advances
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory and Cough-Related Research
- Respiratory viral infections research
- Immune responses and vaccinations
- Blood groups and transfusion
- Celiac Disease Research and Management
University of California, Irvine
2020-2024
UC Irvine Health
2023
University of California, Irvine Medical Center
2023
Columbia University Irving Medical Center
2014-2020
Columbia University
2014-2020
New York Proton Center
2016-2019
Morgan Stanley Children's Hospital
2018
West Virginia University
2011-2015
Louisiana State University Health Sciences Center Shreveport
2008-2015
Louisiana State University Health Sciences Center New Orleans
2008
There is uncertainty about the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in individuals with rare inborn errors immunity (IEI), a population at risk developing disease 2019. This relevant not only for these patients but also general population, because studies IEIs can unveil key requirements host defense.
<h3>Background</h3> Immunodysregulation polyendocrinopathy enteropathy x-linked (IPEX) syndrome is a monogenic autoimmune disease caused by <i>FOXP3</i> mutations. Because it rare disease, the natural history and response to treatments, including allogeneic hematopoietic stem cell transplantation (HSCT) immunosuppression (IS), have not been thoroughly examined. <h3>Objective</h3> This analysis sought evaluate onset, progression, long-term outcome of 2 main treatments in IPEX survivors....
Abstract Background The CDC and ACIP recommend COVID-19 vaccination for patients with inborn errors of immunity (IEI). Not much is known about vaccine safety in IEI, whether attenuates infection severity IEI. Objective To estimate examine effect on outcomes Methods We built a secure registry database conjunction the US Immunodeficiency Network to frequency indicators effectiveness IEI patients. opened January 1, 2022, closed August 19, 2022. Results Physicians entered data 1245 from 24...
We report a 16-year-old male patient who presented with headache, behavior changes, and fever. His cerebral spinal fluid blood cultures grew Cryptococcus neoformans. laboratory evaluation was negative for human immunodeficiency virus infection but flow cytometry revealed low CD4(+) count of 39 cells/mm(3) CD4:CD8 ratio 0.43. He initially treated antifungal agents only partial clinical improvement, he discharged to home on oral fluconazole prophylactic co-trimoxazole. After discharge,...
As the prevalence of food allergies (FAs) increases worldwide, our understanding their pathophysiology and risk factors is markedly expanding. In past few decades, an increasing number genes have been linked to FA. Identification such may help in predicting genetic for FA development, age onset, clinical manifestation, causative allergen(s), possibly optimal treatment strategies. Furthermore, identification these can understand complex interactions between environment predisposition FA.We...
Osimertinib has emerged as an important tool in the treatment of non-small cell lung cancers (NSCLC) with certain activating mutations epidermal growth factor receptor (EGFR). However, may cause adverse effects, including severe cutaneous reactions (SCARs) such Stevens-Johnson syndrome (SJS) and toxic necrolysis (TEN). The risk effects be increased setting recent use immune checkpoint inhibitor (ICI) therapy, although it is unclear whether ICI therapy a for Osimertinib-induced SJS...
Since the start of COVID-19 pandemic, in a short span 3 years, vaccination against SARS-CoV-2 has resulted end pandemic. Patients with inborn errors immunity (IEI) are at an increased risk for infection; however, serious illnesses and mortality, especially primary antibody deficiencies (PADs), have been lower than expected other high-risk groups. This suggests that PAD patients may mount reasonable effective response to vaccine. Several studies published regarding responses, contradictory...
There is controversy on whether allergic contact dermatitis (ACD) associated with atopy. Research eczema and the risk of ACD mixed, there sparse literature other atopic conditions.
Abstract We report a case of newly recognized primary immunodeficiency due to biallelic mutations in CARMIL2 manifesting as an actinic prurigo‐like photodermatitis, allergic diathesis and recurrent infections child. present this highlight rare phenotype seen T‐cell provide overview other dermatologic manifestations among published reports condition.