A5067687988- Immunodeficiency and Autoimmune Disorders
- Gut microbiota and health
- Immunotherapy and Immune Responses
- Blood disorders and treatments
- Immune Cell Function and Interaction
- Clostridium difficile and Clostridium perfringens research
- Food Allergy and Anaphylaxis Research
- COVID-19 Clinical Research Studies
- Acute Lymphoblastic Leukemia research
- Diabetes and associated disorders
- Mechanical Circulatory Support Devices
- T-cell and B-cell Immunology
- SARS-CoV-2 and COVID-19 Research
- Allergic Rhinitis and Sensitization
- Adolescent and Pediatric Healthcare
- Kawasaki Disease and Coronary Complications
- Cystic Fibrosis Research Advances
- Cancer Immunotherapy and Biomarkers
- Inflammasome and immune disorders
- Childhood Cancer Survivors' Quality of Life
- Pathogenesis and Treatment of Hiccups
- Transgenic Plants and Applications
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Blood groups and transfusion
- Congenital heart defects research
National Jewish Health
2024-2025
University of Colorado Denver
2024-2025
Yale University
2015-2024
IE University
2023
University School
2023
University of New Haven
2020
Case Western Reserve University
2010
Hospital of the University of Pennsylvania
2005
Abstract Immunoglobulin A is the dominant antibody isotype found in mucosal secretions and enforces host-microbiota symbiosis mice, yet selective IgA-deficiency (sIgAd) humans often described as asymptomatic. Here, we determined effects of IgA deficiency on human gut microbiota composition evaluated possibility that secretion IgM can compensate for a lack secretory IgA. We used 16S rRNA gene sequencing bacterial cell sorting to evaluate taxa-specific coating 15 sIgAd subjects matched...
Generation of peanut-specific gut immunoglobulin A antibodies is independent T follicular helper cells.
Prenatal antibodies are polyreactive Extensive immunoglobulin gene rearrangements allow humans to recognize a diversity of potential pathogens. This antibody repertoire is more restricted during early life prevent the generation autoreactive B cells, though tolerance does not appear be complete. Chen et al. examined reactivities cloned from individual human fetal cells residing in liver, bone marrow, and spleen. They observed accumulation which were frequently cross-reactive commensals...
ImmunoglobulinA (IgA) is the predominant antibody isotype in gut, where it regulates commensal flora and neutralizes toxins pathogens. The function of food-specific IgA gut unknown but presumed to protect from food allergy. Specifically, has been hypothesized that binds ingested allergens promotes tolerance by immune exclusion; however, evidence support this hypothesis indirect mixed. Although known healthy adults have peanut-specific unclear whether children also IgA. We found a cohort...
Abstract Findings associated with the 22q11.2 deletion often include congenital heart malformations, palatal anomalies, immunodeficiency, hypocalcemia, and developmental delay or learning disabilities. Often clinical suspicion of diagnosis in a patient one more these findings is heightened based on presence characteristic facial appearance. In our large cohort 370 patients deletion, we report under‐representation African‐Americans group, as well as, paucity craniofacial dysmorphism patients....
Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening post-infectious complication occurring unpredictably weeks after mild or asymptomatic SARS-CoV2 infection otherwise healthy children. Here, we define immune abnormalities MIS-C compared to adult COVID-19 and pediatric/adult controls using single-cell RNA sequencing, antigen receptor repertoire analysis, unbiased serum proteomics, vitro assays. Despite no evidence of active infection, uncover elevated S100A-family...
Abstract Background The CDC and ACIP recommend COVID-19 vaccination for patients with inborn errors of immunity (IEI). Not much is known about vaccine safety in IEI, whether attenuates infection severity IEI. Objective To estimate examine effect on outcomes Methods We built a secure registry database conjunction the US Immunodeficiency Network to frequency indicators effectiveness IEI patients. opened January 1, 2022, closed August 19, 2022. Results Physicians entered data 1245 from 24...
The innate immune cytokine interleukin (IL)-1 can affect T cell immunity, a critical factor in host defense. In previous study, we identified subset of human CD4
Hypersensitivity reactions (HSRs) may occur in patients receiving asparaginase for acute lymphoblastic leukemia/lymphoblastic lymphoma and this prevent treatment completion lead to inferior clinical outcomes. Patients with grade 2-4 HSRs an Escherichia coli ( E. coli)- derived are recommended switch Erwinia- asparaginase. In case report, a pediatric patient T-cell leukemia experienced both coli- calaspargase pegol recombinant Erwinia JZP458. After unsuccessful desensitization pegol, we...
ABSTRACT Immunoglobulin A is the dominant antibody isotype found in mucosal secretions and enforces host-microbiota symbiosis mice, yet selective IgA-deficiency (sIgAd) most common primary immunodeficiency humans often described as asymptomatic. Here, we determined effects of IgA deficiency on human gut microbiota composition evaluated possibility that secretion IgM can compensate for a lack secretory IgA. We used 16S rRNA gene sequencing bacterial cell sorting to evaluate or coating 15...