A5028227902- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Pharmacological Effects of Natural Compounds
- Neuroscience and Neuropharmacology Research
- Cell death mechanisms and regulation
- Acute Myeloid Leukemia Research
- Molecular Sensors and Ion Detection
- Sulfur Compounds in Biology
- Microbial Metabolites in Food Biotechnology
- Molecular Junctions and Nanostructures
- Nitric Oxide and Endothelin Effects
- Chronic Lymphocytic Leukemia Research
- X-ray Diffraction in Crystallography
- Ginseng Biological Effects and Applications
- Metabolomics and Mass Spectrometry Studies
- Plant Pathogens and Fungal Diseases
- Receptor Mechanisms and Signaling
- Lymphoma Diagnosis and Treatment
- Seed and Plant Biochemistry
- Ubiquitin and proteasome pathways
- Drug-Induced Hepatotoxicity and Protection
- Neuroinflammation and Neurodegeneration Mechanisms
- Glioma Diagnosis and Treatment
- Crystallization and Solubility Studies
- Multiple Myeloma Research and Treatments
Huazhong University of Science and Technology
2019-2025
Wuhan National Laboratory for Optoelectronics
2019-2025
Beijing Forestry University
2024-2025
Baoji University of Arts and Sciences
2024
Zhejiang University
2015-2024
Huzhou University
2024
Anhui Agricultural University
2024
Ningbo University
2023-2024
University of Minnesota System
2024
East China University of Science and Technology
2023
Histamine is a conserved neuromodulator in mammalian brains and critically involved many physiological functions. Understanding the precise structure of histaminergic network cornerstone elucidating its function. Herein, using histidine decarboxylase (HDC)-CreERT2 mice genetic labeling strategies, we reconstructed whole-brain three dimensional (3D) neurons their outputs at 0.32 × 2 μm 3 pixel resolution with cutting-edge fluorescence microoptical sectioning tomography system. We quantified...
The adsorption and electronic properties of molecules (NO, H2S, SO2, NO2, NH3, N2, CO, CH4, CO2, H2O) on the C6N7 monolayer were systematically studied to explore possibilities C6N7-based toxic gas sensor scavenger by using first-principles methods. We found only NO, SO2 are adsorbed with high strength (ranging -0.853~-0.931 eV), meanwhile other all weak physisorption Ead -0.193~-0.547 eV. NO H2S could remarkably affect monolayer, indicating it is highly sensitive selective towards H2S....
The dorsal raphe nucleus (DR) and median (MR) contain populations of glutamatergic GABAergic neurons that regulate diverse behavioral functions. However, their whole-brain input-output circuits remain incompletely elucidated. We used viral tracing combined with fluorescence micro-optical sectioning tomography to generate a comprehensive atlas inputs outputs in the DR MR. found these received from similar upstream brain regions. same had divergent projection patterns differences critical...
Abstract Multiple sclerosis (MS) is a chronic and debilitating neurological disorder of the central nervous system (CNS), characterized by infiltration leukocytes into CNS subsequent demyelination. Emerging evidences have revealed beneficial roles M2 macrophages in ameliorating experimental autoimmune encephalomyelitis (EAE), model for MS. Here, we identify that lenalidomide alone could promote polarization to prevent progression EAE, which associated with inhibition proinflammatory Th1 Th17...
The present study aimed to investigate the expression of long non-coding HOX transcript antisense RNA (lncRNA-HOTAIR) in serum patients with lymph node metastasis papillary thyroid carcinoma (PTC) and underlying mechanism. A total 89 PTC at Beijing Geriatric Hospital were recruited this study. Based on results color Doppler ultrasound examination, evaluated for cervical metastases, thereby divided into a metastasis-negative group metastasis-positive group. Quantitative fluorescent PCR was...
<title>Abstract</title> The mammalian brain comprises a vast number of neurons, exhibiting remarkable diversity in both molecular composition and spatial distribution. However, comprehensive understanding how these neurons are organized within the remains elusive, largely due to lack systematic studies providing three-dimensional coverage molecularly defined across entire brain. In this study, we utilized transgenic mice fMOST imaging map distribution glutamatergic, GABAergic, modulatory at...
3113 Background: As the most frequently mutated oncogene, KRAS alteration occurring in approximately 25% of all malignancies. Despite extensive efforts, targeting has proven to be challenging due its structure and complex function. Recently, direct G12C inhibitors, such as Sotorasib Adagrasib have occurred first successes. However, therapeutic approaches other variants beyond are under significant unmet needs. Recent developments protein degradation technologies, Proteolysis-Targeting...
A series of 3,4-disubstituted piperidine derivatives were obtained based on a conformational restriction strategy and lead compound, A12, that exhibited potent in vitro vivo antitumor efficacies; however, obvious safety issues limited its further development. Thus, systematic exploration the structure–activity relationship compound involving phenyl group, hinge-linkage, moiety, led to discovery superior 3,4,6-trisubstituted derivative E22. E22 showed increased potency Akt1 cancer cell...