A5067970576- Lymphoma Diagnosis and Treatment
- Platelet Disorders and Treatments
- Porphyrin Metabolism and Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Reproductive System and Pregnancy
- MicroRNA in disease regulation
- Angiogenesis and VEGF in Cancer
- RNA Interference and Gene Delivery
- Multiple Myeloma Research and Treatments
- Lung Cancer Treatments and Mutations
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Virus-based gene therapy research
- Viral Infections and Immunology Research
- RNA modifications and cancer
- Metabolism and Genetic Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Pancreatitis Pathology and Treatment
- Lung Cancer Diagnosis and Treatment
- Neonatal Health and Biochemistry
- RNA Research and Splicing
Peking University
2017-2025
Capital Medical University
2013-2025
Ningbo University
2016-2025
Beijing Tian Tan Hospital
2025
Peking University Cancer Hospital
2025
Yantaishan Hospital
2025
Ningbo University Affiliated Hospital
2024
Moderna Therapeutics (United States)
2018-2024
First Affiliated Hospital of Nanchang University
2020-2024
Nanchang University
2020-2024
Propionic acidemia/aciduria (PA) is an ultra-rare, life-threatening, inherited metabolic disorder caused by deficiency of the mitochondrial enzyme, propionyl-CoA carboxylase (PCC) composed six alpha (PCCA) and beta (PCCB) subunits. We herein report enzyme replacement approach to treat PA using a combination two messenger RNAs (mRNAs) (dual mRNAs) encoding both human PCCA (hPCCA) PCCB (hPCCB) encapsulated in biodegradable lipid nanoparticles (LNPs) produce functional PCC liver. In patient...
Selective platelet release of pro- or anti-angiogenic factors distinctly regulated angiogenesis. We hypothesised that selective angiogenic could differently regulate tumour growth.Breast cancer cell proliferation, cell-induced endothelial tube formation in vitro, and growth vivo were studied the presence protease-activated receptor 1-stimulated releasate (PAR1-PR; rich pro-angiogenic factors) PAR4-PR (rich factors).The PAR1-PR supplementation (10%) similarly enhanced proliferation MCF-7...
Messenger RNA (mRNA) therapeutics delivered via lipid nanoparticles hold the potential to treat metabolic diseases caused by protein deficiency, including propionic acidemia (PA), methylmalonic (MMA), and phenylketonuria (PKU). Herein we report results from multiple independent preclinical studies of mRNA-3927 (an investigational treatment for PA), mRNA-3705 MMA), mRNA-3210 PKU) in murine models each disease. All 3 mRNA exhibited pharmacokinetic/pharmacodynamic (PK/PD) responses their...
Gastric cancer is the fifth most common globally and associated with significant morbidity mortality. Despite its alarming prevalence, limited comparative evidence exists on treatment efficacy prognosis across diverse China populations. To address this, our study used a large-scale dataset from National Cancer Information Database, including data 220,304 patients 53 leading hospitals 27 provinces in China. From 2017 to 2023, early-stage (Stages I-II) gastric diagnoses increased 35.63% of all...
Patients with ALK gene rearrangements often manifest dramatic responses to crizotinib, an inhibitor. Accurate identification of patients ALK-positive non-small cell lung cancer (NSCLC) is essential for the clinical application ALK-targeted therapy. However, assessing EML4-ALK rearrangement in NSCLC remains challenging routine pathology practice. The aim this study was compare diagnostic accuracy FISH, immunohistochemistry (IHC), and real-time quantitative RT-PCR (QPCR) methodologies...
Abstract Objective To compare neuronavigation-assisted intracerebral hematoma puncture and drainage with neuroendoscopic removal for treatment of hypertensive cerebral hemorrhage. Method Ninety-one patients hemorrhage admitted to our neurosurgery department from June 2022 May 2023 were selected: 47 who underwent endoscopic the aid neuronavigation in observation Group A 44 control B. The duration surgery, intraoperative bleeding, clearance rate, pre- postoperative GCS score, National...
Dialkylamino-alkyl-benzamides possess an affinity for melanin, suggesting that labeling of such benzamides with <sup>18</sup>F could potentially produce melanin-targeted PET probes able to identify melanotic melanoma metastases in vivo high sensitivity and specificity. <b>Methods:</b> In this study, <i>N</i>-[2-(diethylamino)ethyl]-4-<sup>18</sup>F-fluorobenzamide (<sup>18</sup>F-FBZA) was synthesized via a 1-step conjugation reaction. The σ-receptor binding <sup>19</sup>F-FBZA determined...
AIMTo evaluate the advantages of endoscopic ultrasound (EUS) in assessment detailed structures pancreatic cystic neoplasms (PCNs) compared to computed tomography (CT) and magnetic resonance imaging (MRI). METHODSAll patients with indeterminate PCNs underwent CT, MRI, EUS.The information, including size, number, presence a papilla/nodule, septum, morphology duct were among three modalities.The size each PCN was determined
<p indent="0mm">Acute lung injury (ALI) is a serious condition characterized by damage to the lungs. Recent research has revealed that activation of NLRP3 inflammasome in alveolar macrophages, type immune cell lungs, plays key role development ALI. This process, known as pyroptosis, contributes significantly ALI pathogenesis. Researchers have conducted comprehensive bioinformatics analyses and identified 15 genes associated with macrophage pyroptosis Among these, emerged crucial regulator....
Bone marrow mesenchymal stem cell (BM-MSC) transplantation has been suggested to be a promising method for the treatment of pulmonary arterial hypertension (PAH), fatal disease currently without effective preventive/therapeutic strategies. However, detailed mechanisms underlying BM-MSC therapy are largely unknown. We designed present study test hypothesis that circulating platelets facilitate homing lung vasculature in rat model PAH induced by monocrotalin (MCT). A single subcutaneous...
Salvianolic acid A (SAA), one of the main derivatives Salvia miltiorrhiza, has been shown to possess anti-inflammatory and anti-thrombotic activities. Its role in inhibiting tumor growth, however, remains elusive. The aim this study was investigate effect SAA on acute myeloid leukemia (AML). Here, showed a dose-dependent cell viability inhibition apoptosis induction AML cells. At molecular level, increased expression Bak decreased Bcl-xL, following by PARP cleavage caspase-3 activation. also...