A5083687851- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Intracerebral and Subarachnoid Hemorrhage Research
- Alzheimer's disease research and treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Platelet Disorders and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Nanoplatforms for cancer theranostics
- Neurological Disease Mechanisms and Treatments
- Biochemical effects in animals
- Genetic Mapping and Diversity in Plants and Animals
- Venous Thromboembolism Diagnosis and Management
- Rice Cultivation and Yield Improvement
- RNA Interference and Gene Delivery
- Blood Coagulation and Thrombosis Mechanisms
- Neuroscience and Neuropharmacology Research
- Traditional Chinese Medicine Analysis
- Neurological Disorders and Treatments
- Photodynamic Therapy Research Studies
- GABA and Rice Research
- 14-3-3 protein interactions
- Cancer Research and Treatments
- Neurosurgical Procedures and Complications
- Nerve injury and regeneration
Second Affiliated Hospital of Zhejiang University
2014-2024
Zhejiang Chinese Medical University
2024
Hangzhou First People's Hospital
2016-2024
Foshan Hospital of TCM
2024
Zhejiang University
2007-2023
Weatherford College
2021
China National Rice Research Institute
2019-2021
Zhejiang Normal University
2009-2019
First Affiliated Hospital Zhejiang University
2018
Nanjing Medical University
2017-2018
Abstract Compared to conventional photothermal therapy (PTT) which requires hyperthermia higher than 50 °C, mild‐temperature PTT is a more promising antitumor strategy with much lower phototoxicity neighboring normal tissues. However, the therapeutic efficacy of always restricted by thermoresistance cancer cells. To address this issue, supramolecular drug nanocarrier fabricated co‐deliver nitric oxide (NO) and agent DCTBT NIR‐II aggregation‐induced emission (AIE) characteristic for PTT. NO...
Background Intravenous and inhalation anesthesia are commonly used in the clinical setting. Recovery of cognitive function elderly patients after surgery has received increased attention. In this study, authors compared recovery different techniques, investigated which technique is safer. The also explored association between apolipoprotein E4 postoperative dysfunction undergoing general anesthesia. Methods A total 2,000 were equally randomly divided into intravenous groups. Total used....
Mitochondrial dysfunction caused by amyloid β-peptide (Aβ) plays an important role in the pathogenesis of Alzheimer disease (AD). Substantial evidence has indicated that mitochondrial permeability transition pore (mPTP) opening is involved Aβ-induced neuronal death and reactive oxygen species (ROS) generation. Astragaloside IV (AS-IV), one major active constituents Astragalus membranaceus, been reported as effective anti-oxidant for treating neurodegenerative diseases. However, molecular...
Abstract Phototherapy, including photodynamic therapy (PDT) and photothermal (PTT), has great promise in the treatment of cancer. However, there are many obstacles that can restrict therapeutic efficacy phototherapy. The hypoxic tumor microenvironment production reactive oxygen species (ROS) PDT. As for PTT, thermotolerance cancer cells may lead to ineffective PTT. In this study, IR780 glycolysis inhibitor lonidamine (LND)-encapsulated liposomes prepared hepatocellular carcinoma. be used as...
beta-Amyloid protein (Abeta), a major component of brain senile plaques in Alzheimer's disease, is known to be directly responsible for the production reactive oxygen species (ROS) and induction apoptosis. In this study, protective effect puerarin, an isoflavone purified from radix Chinese herb Pueraria lobata, on Abeta-induced rat pheochromocytoma (PC12) cultures was investigated. Although exposure PC12 cells 50 microM Abeta25-35 caused significant viability loss apoptotic rate increase,...
Hippocampal glucose hypometabolism has been implicated in the pathogenesis of temporal lobe epilepsy (TLE). However, underlying pathophysiological basis for this remains elusive. The aim study was to investigate relationship between hippocampal and histological changes seen rats after systemic pilocarpine treatment.(18)F-fluorodeoxyglucose (FDG) small-animal positron emission tomography (microPET) performed on day zero (untreated), seven (latent) sixty (chronic phase) initial status...
An increasing number of bicuspid aortic valve (BAV) patients are undergoing transcatheter replacement (TAVR), but the risk brain injury in diffusion-weighted magnetic resonance imaging (DW-MRI) is currently unknown.This study sought to evaluate BAV following TAVR.A total 204 consecutive severe stenosis who underwent TAVR were enrolled. A 83 (40.7%) patients, and other 121 tricuspid (TAV) patients. All received DW-MRI at baseline, after TAVR.Median ages (76 years [interquartile range (IQR):...
Summary The palea and lemma (hull) are grass‐specific organs, determine grain size quality. In the study, AH 2 encodes a MYB domain protein, functions in development of hull grain. Mutation produces smaller grains alters quality including decreased amylose content gel consistency, increased protein content. Meantime, part lost outer silicified cells, induces transformation rough epidermis to inner smooth body was reduced ah2 mutant. We confirmed function by complementation, CRISPR ‐Cas9,...
This study examined whether neuronal hemoglobin (Hb) is present in rats. It then cerebral ischemia or ischemic preconditioning (IPC) affects Hb levels vivo and vitro. In vivo, male Sprague-Dawley rats were subjected to either 15 mins of transient middle artery occlusion (MCAO) with 24 h reperfusion, an IPC stimulus, permanent MCAO (pMCAO), followed 3 days later by pMCAO. vitro, primary cultured neurons exposed 2 oxygen—glucose deprivation (OGD) 22 reoxygenation. Results showed that widely...
Hepatocellular carcinoma (HCC) is a highly malignant tumor that resistant to chemotherapy and immunotherapy. Icaritin (ICT), traditional Chinese medicine, has been reported as an immunoregulatory agent for treating advanced unresectable HCC. ICT induces mitophagy cause immunogenic cell death (ICD); however, the poor bioavailability of limits its therapeutic efficacy clinical use. Therefore, this study aimed assess effect using poly(2-(
Cisplatin (CDDP) is one of the most successful chemotherapeutic agents for cancer therapy. However, CDDP can activate pro-survival autophagy, which inhibits therapeutic efficacy CDDP. Herein, autophagy inhibitor verteporfin (VTPF) integrated into CDDP-conjugated micelles to address this issue. The are prepared by host-guest interaction zwitterionic poly(2-(methacryloyloxy)ethyl phosphorylcholine)-co-poly(2-(methacryloyloxy)ethyl adamantane-1-carboxylate) (P(MPC-co-MAd)) and conjugated...