A5101877088- Lung Cancer Treatments and Mutations
- Glioma Diagnosis and Treatment
- Cardiac Valve Diseases and Treatments
- Spine and Intervertebral Disc Pathology
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Spinal Fractures and Fixation Techniques
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Pregnancy and preeclampsia studies
- Cancer Cells and Metastasis
- Lung Cancer Research Studies
- Mesenchymal stem cell research
- Pelvic and Acetabular Injuries
- Spinal Hematomas and Complications
- Vitamin D Research Studies
- Epilepsy research and treatment
- Cardiac Ischemia and Reperfusion
- Thyroid Disorders and Treatments
- Cardiovascular Function and Risk Factors
- Blood transfusion and management
- Infective Endocarditis Diagnosis and Management
- RNA Research and Splicing
- Circular RNAs in diseases
Wenzhou Medical University
2017-2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2017-2025
Second Affiliated Hospital of Zhejiang University
2014-2024
Tsinghua University
2021-2024
Sun Yat-sen University
2024
Guangdong University of Technology
2022-2024
Tongji University
2024
Zhejiang University
2013-2023
Nanchang University
2023
Anhui Medical University
2023
Background Hypertensive disorders of pregnant women are one the important causes maternal and perinatal morbidity mortality. Evidence showed mental stress might be a risk factor gestational hypertensive disorders. Objective The objective this study was to evaluate relationships between hypertension/preeclampsia in women. Methods Relevant studies were identified by PubMed, Cochrane, Chinese medical datasets (Wanfang, CNKI, VIP Database). Only case-control or cohort evaluating an association...
Hypertension promotes ATP release from erythrocytes, leading to a P2X7-dependent increase in T cell–mediated immune responses.
Abstract Atherosclerosis (AS), a leading cause of cardio-cerebrovascular disease worldwide, is driven by the accumulation lipid contents and chronic inflammation. Traditional strategies primarily focus on reduction to control AS progression, leaving residual inflammatory risks for major adverse cardiovascular events (MACEs). While anti-inflammatory therapies targeting innate immunity have reduced MACEs, many patients continue face significant risks. Another key component in progression...
Abstract Background Lung cancer brain metastases (LC-BrMs) are frequently associated with dismal mortality rates in patients lung cancer; however, standard of care therapies for LC-BrMs still limited their efficacy. A deep understanding molecular mechanisms and tumor microenvironment will provide us new insights into developing novel therapeutics treating LC-BrMs. Methods Here, we performed integrated analyses genomic, transcriptomic, proteomic, metabolomic, single-cell RNA sequencing data...
Objective Previous studies have found that overweight and obesity are related to numerous diseases, including thyroid cancer volume. This study evaluates the relationship between body size presence of nodules in a Chinese population. Methods A total 6793 adults 2410 children who underwent ultrasonography were recruited this cross-sectional Hangzhou, Zhejiang Province, China, from March October, 2010. Sociodemographic characteristics potential risk factors collected by questionnaire. Height...
An increasing number of bicuspid aortic valve (BAV) patients are undergoing transcatheter replacement (TAVR), but the risk brain injury in diffusion-weighted magnetic resonance imaging (DW-MRI) is currently unknown.This study sought to evaluate BAV following TAVR.A total 204 consecutive severe stenosis who underwent TAVR were enrolled. A 83 (40.7%) patients, and other 121 tricuspid (TAV) patients. All received DW-MRI at baseline, after TAVR.Median ages (76 years [interquartile range (IQR):...
Abstract Purpose Epilepsy is one of the most disabling neurological disorders, which affects all age groups and often results in severe consequences. Since misdiagnoses are common, many pediatric patients fail to receive correct treatment. Recently, 18 F-fluorodeoxyglucose positron emission tomography ( F-FDG PET) imaging has been used for evaluation epilepsy. However, epileptic focus very difficult be identified by visual assessment since it may present either hypo- or hyper-metabolic...
8500 Background: Neoadjuvant immune checkpoint inhibitors (ICIs) plus chemotherapy have a promising efficacy in resectable non-small-cell lung cancer (NSCLC), yet the period of neoadjuvant immunochemotherapy is undetermined. This phase II study compared and safety two cycles with three sintilimab stage IB-IIIA NSCLC. Methods: randomized, open-label trial recruited patients aged 18 or older histologically confirmed, treatment-naïve, American Joint Committee on Cancer-defined IB-IIIA, Eligible...
BACKGROUND: Recent studies have shown patient-derived tumor organoids can predict the drug response of patients with cancer. However, prognostic value organoid–based tests in predicting progression-free survival stage IV colorectal cancer after surgery remains unknown. OBJECTIVE: This study aimed to explore surgery. DESIGN: Retrospective cohort study. SETTINGS: Surgical samples were obtained from at Nanfang Hospital. PATIENTS: A total 108 who underwent successful organoid culture and testing...
PET with <sup>18</sup>F-FDG has been used for presurgical localization of epileptogenic foci; however, in nonsurgical patients, the correlation between cerebral glucose metabolism and clinical severity not fully understood. The aim this study was to evaluate metabolic profile using PET/CT imaging patients epilepsy. <b>Methods:</b> One hundred pediatric epilepsy who underwent PET/CT, MRI, electroencephalography examinations were included. Fifteen age-matched controls also images analyzed by...
This study aimed to develop a novel analytic approach based on 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/computed tomography ([18F]FDG PET/CT) radiomic signature (RS) and International Prognostic Index (IPI) predict the progression-free survival (PFS) overall (OS) of patients with diffuse large B-cell lymphoma (DLBCL).We retrospectively enrolled 152 DLBCL divided them into training cohort (n = 100) validation 52). A total 1245 features were extracted from metabolic tumor...
Patient-derived tumor organoids (PDTOs) have the potential to be used predict patient response chemotherapy. However, cutoff value of half-maximal inhibition concentration (IC50) for PDTO drug sensitivity has not been validated with clinical cohort data. We established PDTOs and performed a test in 277 samples from 242 CRC patients who received FOLFOX or XELOX After follow-up comparison final outcome results, optimal IC50 was 43.26 μmol/L. This test-defined could 75.36% sensitivity, 74.68%...
rRNAs are prevalent in living organisms. They produced nucleolus and mitochondria play essential cellular functions. In addition to the primary biofunction protein synthesis, have been recognized as emerging signaling molecule drug target for studies on morphology, mitochondrial autophagy, tumor cell malignancy. Currently, only a few rRNA-selective probes developed, most of them encounter drawbacks low water solubility, poor nuclear membrane permeability, short emission wavelength, stability...
BackgroundPre-clinical studies have shown that hypoxia preconditioning can enhance stem cell therapeutic potential for myocardial repair. We sought to investigate the safety and feasibility of intracoronary administration hypoxia-preconditioned bone marrow mononuclear cells (HP-BMCs) acute ST segment elevation infarction (STEMI).MethodsWe randomized 22 patients with STEMI receive normoxia (N-BMCs) (n = 11) or HP-BMCs following successful reperfusion. Another 14 receiving standard therapy...