A5017424675- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- EEG and Brain-Computer Interfaces
- Glioma Diagnosis and Treatment
- Neurological disorders and treatments
- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Glycogen Storage Diseases and Myoclonus
- Genetics and Neurodevelopmental Disorders
- Cardiovascular Function and Risk Factors
- Psychosomatic Disorders and Their Treatments
- Mitochondrial Function and Pathology
- Neural dynamics and brain function
- Bipolar Disorder and Treatment
- Autophagy in Disease and Therapy
- Drug Transport and Resistance Mechanisms
- Neonatal and fetal brain pathology
- Cardiovascular Disease and Adiposity
- Adipose Tissue and Metabolism
- Photoreceptor and optogenetics research
- Lung Cancer Research Studies
- Diagnosis and Treatment of Venous Diseases
Second Affiliated Hospital of Zhejiang University
2016-2025
Chongqing Cancer Hospital
2020-2024
Chongqing University
2020-2024
University of Rochester
2024
81th Hospital of PLA
2024
Zhejiang University
2010-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
1999-2022
Peking Union Medical College Hospital
2022
Zhejiang Chinese Medical University
2022
Xinyu University
2021
Inflammation and loss of articular cartilage are considered the major cause temporomandibular joint osteoarthritis (TMJOA), a painful condition (TMJ). To determine TMJ in these patients, synovial fluid TMJOA patients was compared prior to after hyaluronic lavage, revealing substantially elevated levels interleukin (IL) 1β, reactive oxidative stress (ROS), an overload Fe
Objective: The objective of the study is to investigate gender and socioeconomic disparities in global burden epilepsy by prevalence disability-adjusted life-years (DALYs). Methods: global, regional, national gender-specific DALYs caused year age were extracted from Global Burden Disease (GBD) Study 2017. Gini coefficient concentration index (CI) calculated demonstrate trends between-country inequality 1990 Paired Wilcoxon signed rank test, Pearson correlation, linear regression analyses...
To investigate how etiology and seizure localization influence ictal scalp electroencephalographic (EEG) patterns in temporal lobe epilepsy (TLE). We retrospectively analyzed EEG features from 504 focal seizures recorded 189 TLE patients with various etiologies who underwent resective surgery. For onset (SOPs), α/β was more common the low-grade tumor group (38.4%) than hippocampal sclerosis (HS) (14.1%, p < 0.001). The duration shorter compared to cortical dysplasia (FCD), HS, non-specific...
Abstract Epilepsy is considered a circuit-level dysfunction associated with imbalanced excitation-inhibition, it therapeutically necessary to identify key brain regions and related circuits in epilepsy. The subiculum an essential participant epileptic seizures, but the circuit mechanism underlying its role remains largely elusive. Here we deconstruct diversity of subicular mouse model We find that excitatory pyramidal neurons heterogeneously control generalization hippocampal seizures by...
Abstract Purpose Epilepsy is one of the most disabling neurological disorders, which affects all age groups and often results in severe consequences. Since misdiagnoses are common, many pediatric patients fail to receive correct treatment. Recently, 18 F-fluorodeoxyglucose positron emission tomography ( F-FDG PET) imaging has been used for evaluation epilepsy. However, epileptic focus very difficult be identified by visual assessment since it may present either hypo- or hyper-metabolic...
To detect serum adipsin levels in individuals with different glucose tolerance, and investigate the relationship between adipsisn first phase of insulin secretion.A total 56 patients newly diagnosed type 2 diabetes mellitus, 36 impaired tolerance (IGT) 45 normal were enrolled. Intravenous tests carried out to evaluate pancreatic β-cell function. The adipsin, interleukin-1β high-sensitivity C-reactive protein assayed.Serum significantly lower mellitus IGT than those group (P < 0.05). acute...
Abstract Objective Sleep strongly activates interictal epileptic activity through an unclear mechanism. We investigated how scalp sleep slow waves (SSWs), whose positive and negative half‐waves reflect the fluctuation of neuronal excitability between up down states, respectively, modulate events in focal epilepsy. Methods Simultaneous polysomnography was performed 45 patients with drug‐resistant epilepsy during intracranial electroencephalographic recording. Scalp SSWs spikes ripples (80–250...
Interictal epileptiform discharges (IEDs) often co-occur across spatially-separated cortical regions, forming IED networks. However, the factors prompting propagation remain unelucidated. We hypothesized that slow oscillations (SOs) might facilitate propagation. Here, amplitude and phase synchronization of SOs preceding propagating non-propagating IEDs were compared in 22 patients with focal epilepsy undergoing intracranial electroencephalography (EEG) evaluation. Intracranial channels...
Malformations of cortical development (MCD) are a group congenital brain malformation disorders commonly associated with pharmacoresistant epilepsy (PRE). While studies often focus on surgery outcomes, the pharmacological treatment is still imperative and odyssey to PRE remains underexplored. We aim investigate influence anti-seizure medications (ASMs) in this specific patient population. retrospectively included cohort patients MRI-confirmed MCD due abnormal cell proliferation apoptosis...
Autoimmune limbic encephalitis (ALE) often occurs with detectable neuronal antibodies, presenting seizures as a prominent clinical manifestation. We aimed to investigate the characteristics and seizure outcomes in cohort antibody-positive ALE. consecutively recruited patients ALE new-onset between July 2014 February 2024. Their demographic, clinical, paraclinical characteristics, treatment were collected. Seizure during follow-up evaluated respectively, well associated risk factors....
Abstract Objective Ketogenic diet therapy (KDT) is a safe and effective intervention for drug‐resistant epilepsy (DRE), yet its neural mechanisms remain unclear. This study aimed to explore how KDT‐induced changes in brain network dynamics relate therapeutic efficacy. Methods Resting‐state functional magnetic resonance imaging was performed on 38 DRE patients at both pre‐ post‐KDT stages, alongside 35 healthy controls. Using energy landscape analysis, we assessed individualized dynamics,...
Abstract Background Intronic pentanucleotide insertion in the sterile alpha motif domain‐containing 12 gene was recently identified as genetic cause of familial cortical myoclonic tremor with epilepsy type 1. Objectives We thereafter conducted a multimodal MRI research to further understand Methods enrolled 31 patients carrying heterozygous pathogenic intronic and age‐ sex‐matched healthy controls. compared metrics, including voxel‐based morphometry, fractional anisotropy diffuse tensor...
<i>Background/Aims:</i> Insulinoma is a rare and potentially curable disease. It often misdiagnosed as neurological or psychiatric disorder. This study was performed to characterize the neuropsychiatric symptoms (PNS) of patients with insulinoma from regional clinical center. <i>Methods:</i> All medical records histopathologically identified were reviewed during period 1998 2008. A case-control analysis compare demographic data, details presentation, biochemical...