Lei Ren

ORCID: 0000-0002-5770-3271
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About
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Research Areas
  • Mental Health Research Topics
  • Functional Brain Connectivity Studies
  • Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Impact of Technology on Adolescents
  • Digital Mental Health Interventions
  • Tryptophan and brain disorders
  • Child and Adolescent Psychosocial and Emotional Development
  • Psychological Well-being and Life Satisfaction
  • Behavioral Health and Interventions
  • Resilience and Mental Health
  • Schizophrenia research and treatment
  • Health disparities and outcomes
  • Psychological and Temporal Perspectives Research
  • Radiomics and Machine Learning in Medical Imaging
  • Medical Imaging Techniques and Applications
  • Lung Cancer Diagnosis and Treatment
  • Cancer Research and Treatments
  • Health, psychology, and well-being
  • COVID-19 and Mental Health
  • Suicide and Self-Harm Studies
  • Complex Network Analysis Techniques
  • Diabetic Foot Ulcer Assessment and Management
  • Child Development and Digital Technology
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Single-cell and spatial transcriptomics

Academy of Military Transportation
2024-2025

Chinese People's Liberation Army
2022-2025

Logistics University of People's Armed Police Force
2024-2025

Air Force Medical University
2013-2024

Chinese People's Armed Police Force
2024

University of Maryland, Baltimore
2024

Guilin Medical University
2023

Xiamen University
2023

Chengde Medical University
2023

Affiliated Hospital of Jining Medical University
2023

Abstract Micro-nano biorobots based on bacteria have demonstrated great potential for tumor diagnosis and treatment. The bacterial gene expression drug release should be spatiotemporally controlled to avoid in healthy tissues undesired toxicity. Herein, we describe an alternating magnetic field-manipulated tumor-homing developed by genetically modifying engineered Escherichia coli with Fe 3 O 4 @lipid nanocomposites. After accumulating orthotopic colon tumors female mice, the paramagnetic...

10.1038/s41467-023-37225-1 article EN cc-by Nature Communications 2023-03-23

Abstract Background Comorbidity between depressive and anxiety disorders is common. From network perspective, mental arise from direct interactions symptoms comorbidity due to depression symptoms. The current study investigates the structure of in Chinese female nursing students identifies central bridge as well how other present are related symptom “thoughts death”. Methods To understand full spectrum anxiety, we recruited 776 with that span range normal abnormal. Depression were measured...

10.1186/s12888-021-03276-1 article EN cc-by BMC Psychiatry 2021-05-31

Existing research proposed that moving from a disorder-level analysis to symptom-level may provide more fine-grained understanding of psychopathology. This study aimed explore the relations between two dimensions (i.e., cognitive reappraisal, CR; expressive suppression, ES) emotion regulation and individual symptoms depression anxiety among medical staff during late stage COVID-19 pandemic. We examined symptoms, 420 pandemic via network analysis. Two networks (i.e. regulation-depression...

10.1016/j.psychres.2022.114863 article EN cc-by-nc Psychiatry Research 2022-09-25

Abstract Background There are 68.77 million left-behind children in China, who at a great risk of depression associated with negative life events. Our study aims to investigate the most central symptoms and relationship between depressive events using network analysis. Method A cross-sectional data set ( N = 7255) was used, which included adolescents aged 7 17. Network analysis used evaluate: 1) among items Child Depression Inventory (CDI) children; 2) bridge disorder Adolescent Self-Rating...

10.1186/s12888-021-03445-2 article EN cc-by BMC Psychiatry 2021-09-01

Prior studies have revealed the relationships between impulsivity and social media addiction (SMA) problematic smartphone use (PSU) based on total scores standardized self-report scales. However, there has been a lack of exploring how dimensions components SMA or PSU are interrelated. The present study aimed to investigate structural determine critical bridge node using network analysis.A 325 healthy adults aged 18-36 years participated in study. were assessed Bergen Social Media Addiction...

10.3389/fpsyt.2022.993328 article EN cc-by Frontiers in Psychiatry 2022-10-18

Existing research has demonstrated that problematic smartphone use (PSU) may reflect a composition of heterogeneous symptoms, with individual PSU symptoms uniquely related to predisposing variables. The Big Five personality traits represent one the most frequently examined variables in relation PSU. However, no studies date have trait-to-symptom association between and Using network analysis approach, we aimed understand: 1) specific pathways linking each 2) bridging effects trait on symptom...

10.1556/2006.2022.00093 article EN cc-by-nc Journal of Behavioral Addictions 2023-02-10

Objective: Sufferers of tinnitus, especially the prolonged type, frequently suffer from comorbid depression and anxiety. From perspective network model, this comorbidity is thought to be an interacting system these two symptoms. In our study, we conducted a analysis anxiety in tinnitus sufferers, aiming identify central bridge symptoms make informed suggestions for clinical interventions psychotherapy. Method: A total 566 sufferers were enrolled study. The Patient Health Questionnaire-9...

10.3390/brainsci13040583 article EN cc-by Brain Sciences 2023-03-30

Background Problematic smartphone use (PSU) has become an issue of great concern in the age smartphones. PSU is associated with emotional problems, one which depression, as shown by empirical studies. However, previous studies have been limited that they focused solely on total score for symptoms and depression while ignoring symptomatic heterogeneity these two concepts. Method This study filled this gap exploring links between among 1,849 university students (59.17% female participants,...

10.3389/fpubh.2022.981136 article EN cc-by Frontiers in Public Health 2023-01-17

Abstract Background A temporal network of generalized anxiety disorder (GAD) symptoms could provide valuable understanding the occurrence and maintenance GAD. We aim to obtain an exploratory conceptualization GAD identify central symptom. Methods sample participants ( n = 115) with elevated GAD-7 scores (Generalized Anxiety Disorder 7-Item Questionnaire [GAD-7] ≥ 10) participated in online daily diary study which they reported their based on DSM-5 diagnostic criteria (eight total) for 50...

10.1186/s12888-024-05698-z article EN cc-by BMC Psychiatry 2024-03-29

The mental health burden among adolescents has been increasing, impacting individuals even before formal diagnosis of common disorders. Although personality traits, as key indicators conditions, play a crucial role in the development disorders, there is gap regarding trait-to-symptom pathways and similarities differences between young adults. A total 860 1751 adults participated this study. Chinese Big Five Personality Inventory assessed while depression anxiety symptoms were measured using...

10.1186/s12888-025-06675-w article EN cc-by-nc-nd BMC Psychiatry 2025-03-14

Abstract Purpose Epilepsy is one of the most disabling neurological disorders, which affects all age groups and often results in severe consequences. Since misdiagnoses are common, many pediatric patients fail to receive correct treatment. Recently, 18 F-fluorodeoxyglucose positron emission tomography ( F-FDG PET) imaging has been used for evaluation epilepsy. However, epileptic focus very difficult be identified by visual assessment since it may present either hypo- or hyper-metabolic...

10.1007/s00259-020-05108-y article EN cc-by European Journal of Nuclear Medicine and Molecular Imaging 2021-01-09

Abstract Background As a common social phenomenon, nurses’ occupational burnout has high incidence rate, which seriously affects their mental health and nursing level. The current assessment mostly uses the total score model explores influence of external factors on burnout, while correlation between items or dimensions is less explored. Ignoring may result in limited understanding nurse burnout. This paper item dimension network structure Maslach Burnout Inventory-General Survey (MBI-GS)...

10.1186/s12912-021-00670-8 article EN cc-by BMC Nursing 2021-08-17

Abstract Background Intolerance of uncertainty (IU) is considered as a specific risk factor in the development and maintenance generalized anxiety disorder (GAD). Yet, researches have investigated relations between IU GAD (or worry) using total scores on self-report measures. This ignores that there are different components exist heterogeneity symptoms. In present study, we explored among symptoms GAD. Methods A dimensional approach which take individual differences into consideration along...

10.1186/s12888-021-03455-0 article EN cc-by BMC Psychiatry 2021-09-10

The network perspective of mental disorder offers a novel way understanding the psychopathology post-traumatic stress (PTSD). In this framework, PTSD may arise from direct interactions between its symptoms. present study, we used Post-Traumatic Stress Disorder Checklist-civilian Version (PCL-C) to investigate structure symptoms in 994 Chinese male firefighters. We also calculated micro (i.e., edges weight and node expected influence) middle community) indicators final network. Nine strongest...

10.1016/j.ajp.2022.103062 article EN cc-by-nc-nd Asian Journal of Psychiatry 2022-03-11

Background Existing research has demonstrated that intolerance of uncertainty (IU) is associated with problematic smartphone use (PSU). However, little known about how different IU components such as uncertainty-related beliefs, emotions, and behaviors may impact on PSU symptoms. Methods Extending previous research, the current study examined specific associations between symptoms via a symptom-level network approach. A regularized partial correlation consisting was estimated among 1,849...

10.3389/fpsyt.2022.917833 article EN cc-by Frontiers in Psychiatry 2022-07-11

Returning to social life after the lifting of COVID-19 lockdown may increase risk anxiety, which is highly co-morbid with depression. However, few studies have reported association between them.To explore complex relationship anxiety and depression symptoms in left-behind children lockdown.A cross-sectional survey was conducted 6 months removal. A total 3,107 completed a mean age 13.33 response rate 87.77%. Depression severity were assessed by DSM-5 Patient Health Questionnaire for...

10.1177/00207640221141784 article EN International Journal of Social Psychiatry 2022-12-13

Background Abuse experiences in adolescents are associated with the risk of depression and suicide. Thus, there is an urgent need to develop prevention intervention measures for clinicians, policymakers, researchers. Methods Network analysis method was used analyze cross-sectional data Chinese this study. The Patient Health Questionnaire Adolescents (PHQ-A) assessing depression, which item 9 PHQ-A assess suicide ideation, International Society Prevention Child Neglect (ISPCAN) Screening...

10.3389/fpsyt.2022.853951 article EN cc-by Frontiers in Psychiatry 2022-03-28

Abstract Background There is conclusive evidence of a multifaceted and bidirectional relationship between loneliness depression anxiety. Nonetheless, more extensive research needed to examine their relationships at granular level. This study employed network analysis approach identify the pathological mechanisms underpinning those important bridge nodes as potential targets for intervention. Methods 941 University students were included in this study. The ULS-6 (the short-form UCLA...

10.1186/s12889-023-17435-4 article EN cc-by BMC Public Health 2023-12-13
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