ABSTRACT Objectives This study aimed to compare the clinical efficacy of dual‐time 68 Ga‐pentixafor PET/CT with adrenal vein sampling (AVS) in PA lateralization. Methods and We retrospectively analysed 161 patients PA. assessed diagnostic performance diagnosing unilateral primary aldosteronism (UPA) aldosterone‐producing adenoma (APA). also explored relationship between findings, postoperative outcomes, presence KCNJ5 gene mutation. Results The accuracy PET at 10 40 min for UPA (75.2% 76.4%,...

Prior studies have revealed the relationships between impulsivity and social media addiction (SMA) problematic smartphone use (PSU) based on total scores standardized self-report scales. However, there has been a lack of exploring how dimensions components SMA or PSU are interrelated. The present study aimed to investigate structural determine critical bridge node using network analysis.A 325 healthy adults aged 18-36 years participated in study. were assessed Bergen Social Media Addiction...

Abstract Transitioning from holistic analysis to a fine-grained level may provide further understanding of psychopathology. This study aimed explore dimension-level relationships between suicidal ideation, meaning in life, and affect joint framework using network identify potential prevention intervention targets address ideation. A total 852 healthy adults aged 18–35 years completed self-report scales assess affect. regularized partial correlation was then built examine the links these...

Coordination is crucial for individuals to achieve common goals; however, the causal relationship between coordination behavior and neural activity has not yet been explored. Interbrain synchronization (IBS) efficiency in cortical areas associated with mirror neuron system (MNS) are considered two potential brain mechanisms. In present study, we attempted clarify how mechanisms facilitate using hypertranscranial electrical stimulation (hyper-tES). A total of 124 healthy young adults were...

Chronic obstructive pulmonary disease (COPD) is a major public health problem and cause of mortality worldwide. However, COPD in the early stage usually not recognized diagnosed. It necessary to establish risk model predict development.A total 441 patients 192 control subjects were recruited, 101 single-nucleotide polymorphisms (SNPs) determined using MassArray assay. With 5 clinical features as well SNPs, 6 predictive models established evaluated training set test by confusion matrix...

Background Evidence from previous studies has confirmed that functionally impaired elderly individuals are susceptible to comorbid anxiety and depression. Network theory holds the comorbidity emerges interactions between depression symptoms. This study aimed investigate fine-grained relationships among symptoms in identify central bridge provide potential targets for intervention of these two disorders. Methods A total 325 five communities Xi'an, China, were recruited our investigation. The...

Anxiety and depression are among the greatest contributors to global burden of diseases. The close associations personality traits with anxiety have been widely described. However, common practice sum scores in previous studies limits understanding fine-grained connections between different symptoms cannot explore compare risk or protective effects on symptoms.We aimed determine identify detrimental symptoms.A total 536 college students from China were recruited online, average age was 19.98...

Abstract Background Previous studies have investigated the relationships between psychache or meaning in life and suicidal ideation based on sum score of corresponding scale. However, this practice has hampered fine-grained understanding their relationships. This network analysis study aimed to conduct a dimension-level these constructs among them joint framework, identify potential intervention targets address ideation. Methods Suicidal ideation, psychache, were measured using self-rating...

Maresin-1 is an antiphlogistic agonist synthesized by macrophages from docosahexaenoic acid (DHA). It has both anti-inflammatory and pro-inflammatory properties been found to enhance neuroprotection cognitive function. However, there limited knowledge of its effects on depression the potential mechanism remains unclear. In this study, lipopolysaccharide (LPS)-induced depressive symptoms neuroinflammation were investigated in mice possible cellular molecular mechanisms further clarified....

Major depression is a serious and chronic mental illness. However, its etiology poorly understood. Although glial cells have been increasingly implicated in the pathogenesis of depression, specific role microglia astrocytes stress-induced remains unclear. Translocator protein (TSPO) has long considered marker neuroinflammation microglial activation. this also present on astrocytes. Thus, it necessary to explore relationships between TSPO, microglia, context depression. In study, C57BL/6J...

Background Behavioral inhibition/activation systems (BIS/BAS) and impulsivity are associated with problematic smartphone use (PSU). However, no studies to date have explored how the subdomains of BIS/BAS dimensions relate components PSU in a joint framework. This study aimed examine relationships between three constructs at fine-grained level identify central nodes bridge their using network analysis. Methods A regularized partial correlation PSU, BIS/BAS, communities was estimated...

Executive functions are of vital importance in the process active cognition, which is thought to be associated with dorsolateral prefrontal cortex (DLPFC). As a valid brain stimulation technology, high-definition transcranial direct current (HD-tDCS) has been used optimize cognitive function healthy adults. Substantial evidence indicates that short-term or single anodal tDCS sessions over left DLPFC will enhance performance executive functions. However, changes and cortical activation after...

Problematic smartphone use (PSU) is associated with both anxiety and depression. However, the relationships between components of PSU symptoms or depression have not been investigated. Hence, aim this study was to closely examine identify pathological mechanisms underpinning those relationships. A second important bridge nodes potential targets for intervention.Symptom-level network structures anxiety, were constructed investigate connections variables evaluate expected influence (BEI) each...

Patients with coronavirus disease 2019 (COVID-19) are predisposed to associated mental health problems, including intolerance of uncertainty (IUS), perceived stress (PSS), low sense control, dysfunctional beliefs and attitudes about sleep (DBAS), insomnia, impaired feeling security. However, these concerns have not been studied in a joint framework. This study aimed investigate the relationships putative causality among aforementioned six variables determine relatively important ones,...

Major depressive disorder (MDD) is a highly pervasive, severe psychological condition for which the precise underlying pathophysiology incompletely understood, although microglial activation known to play role in this context. In study we analyzed association between neuroinflammation and depressive-like behaviors lipopolysaccharide (LPS)-induced mouse model system using 10-12-week-old male C57BL/6 mice. Microglial associated neuroinflammatory activity were monitored via positron emission...

Abstract Background Executive function enhancement is considered necessary for improving the quality of life patients with neurological or psychiatric disorders, such as attention‐deficit/hyperactivity disorder, obsessive‐compulsive disorder and Alzheimer's disease. Transcranial electrical stimulation (tES) has been shown to have some beneficial effects on executive functioning, but quantification these improvements remains controversial. We aimed explore potential functioning induced by use...

Background Previous studies have confirmed that both affect and emotion regulation strategies are closely associated with psychological capital (PsyCap) resilience. These factors assumed to buffer the effect of COVID-19 pandemic on mental health, especially among males. However, these interactions not been examined date. To fill this gap, paper explores dimension-level relationships constructs Chinese males during late stage identified critical bridge dimensions using network analysis....

Prior studies have focused on single-target anodal transcranial direct current stimulation (tDCS) over the right inferior frontal gyrus (rIFG) or pre-supplementary motor area (pre-SMA) to improve response inhibition in healthy individuals. However, results are contradictory and effect of multitarget both brain regions has never been investigated. The present study aimed investigate behavioral neurophysiological effects different forms high-definition tDCS (HD-tDCS) improving inhibition,...

Few studies have investigated the effects of repeated sessions transcranial direct current stimulation (tDCS) combined with concurrent cognitive training on improving response inhibition, and findings been heterogeneous in limited research. This study long-lasting transfer 10 consecutive multitarget anodal HD-tDCS inhibition compared or alone.Ninety-four healthy university students aged 18-25 were randomly assigned to undergo different interventions, including real stop-signal task (SST)...

Background: The prevailing mobile phone use brought the problem of addiction, which might cause negative consequences. Effortful control and mind wandering were associated with addictive behavior. present study aimed to investigate dimension-level relationships between effortful control, wandering, addiction. Methods: A total 1684 participants participated this study. measured through self-report scales, respectively. Dimension-level network these psychological variables was estimated bridge...

High-definition transcranial direct current stimulation (HD-tDCS) is a valid brain technology to optimize cognitive function. Recent evidence indicates that single anodal tDCS session enhances attention; however, the variation in attention produced by repeated HD-tDCS over longer period of time has not been explored. We examined modulation function healthy young participants (39 adults) who received sustained for 4 weeks. The results showed robust benefit on executive control and psychomotor...

Background Acute stress reaction (ASR) following a stressful event is associated with stress-related mental disorders. However, no studies have investigated the relationships between ASR symptom clusters. The present study aimed to provide fine-grained understanding of complex among clusters and identify central using network analysis. Methods Stress Reaction Scale (ASRS) was used investigate structure in 1792 Chinese male military college students who were about participate an important...