A5020462375- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Epilepsy research and treatment
- Viral Infections and Immunology Research
- Polysaccharides and Plant Cell Walls
- Animal Disease Management and Epidemiology
- Immune cells in cancer
- Animal Virus Infections Studies
- Tendon Structure and Treatment
- Coastal and Marine Dynamics
- Fungal Biology and Applications
- Botanical Research and Applications
- Geological formations and processes
- Polysaccharides Composition and Applications
- Autoimmune Bullous Skin Diseases
- Burn Injury Management and Outcomes
- Viral Infectious Diseases and Gene Expression in Insects
- Multiple Myeloma Research and Treatments
- Gut microbiota and health
- Dermatology and Skin Diseases
- Reproductive Biology and Fertility
- Wound Healing and Treatments
- Microbial Metabolites in Food Biotechnology
- Cell Adhesion Molecules Research
- Pharmacological Effects of Natural Compounds
Second Affiliated Hospital of Zhejiang University
2022-2024
Key Laboratory of Guangdong Province
2022-2023
Zhejiang University
2020-2023
First Affiliated Hospital of Xi'an Jiaotong University
2023
Zhejiang Ocean University
2023
Sun Yat-sen University
2022
Nanjing Medical University
2022
Jiangsu Province Hospital
2022
Wan Fang Hospital
2022
Burn injury remains one of the most devastating burdens on global public health. The inflammation, caused by burn and transplantation dermal scaffolds, often leads to delayed wound healing. Esculentoside A (EsA), with a strong anti-inflammatory capacity, is an available agent that might contribute treatment wounds. However, poor stability toxicity EsA limit its clinical application. In present study, we constructed chitosan/alginate nanoparticles (EsA-CS/ALG-NPs) improve sustainability...
Abstract Objective Ketogenic diet therapy (KDT) is a safe and effective intervention for drug‐resistant epilepsy (DRE), yet its neural mechanisms remain unclear. This study aimed to explore how KDT‐induced changes in brain network dynamics relate therapeutic efficacy. Methods Resting‐state functional magnetic resonance imaging was performed on 38 DRE patients at both pre‐ post‐KDT stages, alongside 35 healthy controls. Using energy landscape analysis, we assessed individualized dynamics,...
Osteosarcoma (OS), a prevalent primary malignant bone tumor in children and adolescents, has maintained consistent treatment protocols since the 1970s combining surgery, chemotherapy, radiotherapy. While effective for localized tumors, these strategies show limited efficacy against metastatic or recurrent cases. Although emerging immunotherapies (PD-1 inhibitors, CAR-T-cell therapy) demonstrate therapeutic potential, their clinical impact remains constrained by tumor’s low immunogenicity...
Allergic asthma is a refractory disease that affects hundreds of millions people worldwide. Betanin natural plant-derived nutrient and possesses health-promoting properties. The effects betanin on allergic remain unknown. Herein, the mechanisms were explored in ovalbumin (OVA)-induced BALB/c mice. doses 0, 20, 60, 180 mg/kg was applied. Peripheral inflammatory cells, IgE, pulmonary pathology, T cell subsets, cytokine levels, protein expressions cAMP-PKA-CREB/CREM pathway, gut microbial...
Psoriasis, an immune-mediated inflammatory disease, is associated with poor pregnancy outcomes. Emerging evidence indicates that these defects are likely attributed to compromised oocyte competence. Nevertheless, little known about the underlying mechanisms between psoriasis and quality. In this study, we construct imiquimod-induced chronic psoriasis-like mouse model review effects of on We discover oocytes from mice display spindle/chromosome disorganization, kinetochore-microtubule...
Cardiovascular diseases are associated with platelet hyperactivity, and downregulating activation is one of the promising antithrombotic strategies. This study newly extracted two polysaccharides (purified exopolysaccharides, EPSp purified intercellular IPSp) from Cordyceps sinensis Cs-4 mycelial fermentation powder, investigated effects their gut bacterial metabolites on functions thrombus formation. IPSp majorly composed galactose, mannose, glucose, arabinose. Both mainly contain 4-Galp...
Abstract Aims This study aimed to evaluate the safety of reducing or withdrawing anti‐seizure medications (ASMs) in a cohort comprising both adults and children with drug‐resistant epilepsy (DRE) undergoing ketogenic diet therapy (KDT). Methods We conducted comprehensive analysis clinical profiles DRE who had adhered KDT for at least 6 months. Successful withdrawal reduction an ASM was defined as discontinuation dose without subsequent resumption increase initiation any new throughout entire...
In this study, a morphodynamic numerical model is established with the Regional Ocean Modeling System (ROMS) to investigate transient behavior of sand waves under realistic sea conditions. The simulation wave evolution comprises two steps: 1) regional-scale configured first simulate ocean hydrodynamics, i.e., tides and tidal currents, 2) simulated in small computational domain time-variant currents extracted from large model. on continental shelf Beibu Gulf specifically investigated. results...
Abstract Background: Outbreaks of Classical swine fever virus (CSFV) cause significant economic losses in the industry. Vaccination is major method to prevent and control disease. As live attenuated vaccines fail elicit differentiable immunity between infected vaccinated animals, subunit vaccine was considered as an alternative candidate eradicate CSFV. Subunit present advantages DIVA immunogenicity safety. The technology limited due low yield high cost with multiple large doses. native E2...
Abstract Background: Outbreaks of Classical swine fever virus (CSFV) cause significant economic losses in the industry. Vaccination is major method to prevent and control disease. As live attenuated vaccines fail elicit differentiable immunity between infected vaccinated animals, subunit vaccine was considered as an alternative candidate eradicate CSFV. Subunit present advantages DIVA immunogenicity safety. The technology limited due low yield high cost with multiple large doses. native E2...