A5043479363- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Alzheimer's disease research and treatments
- Reproductive Biology and Fertility
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Ubiquitin and proteasome pathways
- Cell Adhesion Molecules Research
- Dementia and Cognitive Impairment Research
- Renal cell carcinoma treatment
- Cancer Cells and Metastasis
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Immune cells in cancer
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Inflammatory Biomarkers in Disease Prognosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Drug Transport and Resistance Mechanisms
- Genetic Associations and Epidemiology
- Animal Nutrition and Physiology
Zhejiang University
2017-2025
First People's Hospital of Yunnan Province
2022-2025
Kunming University of Science and Technology
2022-2025
Tongji University
2025
National Center for Nanoscience and Technology
2014-2024
Lishui University
2024
University of Chinese Academy of Sciences
2017-2024
Yangzhou University
2022-2024
Wuxi People's Hospital
2024
Goethe University Frankfurt
2024
CD44/CD24 and ALDH1 are widely used cancer stem cell (CSC) markers in breast cancer. However, their expression is not always consistent even the same subtype of Systematic comparison functions still lacking. We investigated CD44, CD24 different subtypes cells, explored relationship with progression. defined a parameter ratio to present level CD44 found that high ALDH1+ both indicators for malignancy, but play during tumor High more related proliferation tumorigenesis, which confirmed by...
Exosomes are endosome-derived membrane vesicles carrying proteins and nucleic acids that involved in cellular functions such as intercellular communication, protein RNA secretion, antigen presentation. Therefore, exosomes serve potential biomarkers for many diseases including cancer. Because difficult to enrich or purify from biofluids, quantification of is tedious inaccurate. Here, we present a real-time, label-free, quantitative method detect characterize tumor-derived without enrichment...
Due to its amazing ability manipulate light at the nanoscale, plasmonics has become one of most interesting topics in field light–matter interaction. As a promising application plasmonics, surface-enhanced Raman scattering (SERS) been widely used scientific investigations and material analysis. The large enhanced signals are mainly caused by extremely electromagnetic that results from localized surface plasmon polaritons. Recently, novel SERS technology called remote reported, combining both...
Multifunctional nanoplatforms for imaging-guided synergistic antitumor treatment are highly desirable in biomedical applications. However, anticancer is largely affected by the pre-existing hypoxic tumor microenvironment (TME), which not only causes resistance of tumors to photodynamic therapy (PDT), but also promotes tumorigenesis and progression. Here, a continuous O
N6 -methyladenosine (m6 A) modulators decide the fate of m6 A-modified transcripts and drive cancer development. RNA interference targeting A promise to be an emerging therapy but is challenging due its poor tumor high systematic toxicity. Here engineered small extracellular vesicles (sEVs) with CD47 expression cyclic arginine-glycine-aspartic (c(RGDyC)) modification are developed for effective delivery short interfering against reader YTH N6-methyladenosine binding protein 1 (YTHDF1) treat...
Lactate is present at a high level in the microenvironment of mammalian preimplantation embryos vivo and vitro. However, its role development unclear. Here, we report that lactate highly enriched nuclei early when major zygotic genome activation (ZGA) occurs humans mice. The inhibition production uptake results developmental arrest 2-cell stage, ZGA failure, loss lactate-derived H3K18lac, which could be rescued by addition Lac-CoA recapitulated overexpression H3K18R mutation. By profiling...
BackgroundUncoordinated 51-like kinase 1 (ULK1) plays a vital role in autophagy. ULK1 dysregulation has recently been found several human cancers.MethodsmRNA expression levels of and clinical information were analysed from The Cancer Genome Atlas data. verified 36 paired fresh ccRCC tissue specimens by western blot analysis. Expression was knockdown shRNA lentivirus. activity inhibited SBI-0206965. effect inhibition measured detecting the apoptotic rate, autophagy, ratio ROS NADPH. efficacy...
Rationale: Glioma is the most common malignant primary brain tumor in central nervous system (CNS).The lack of reliable noninvasive diagnostic and prognostic methods one main reasons for high mortality glioma.Serum has become a useful biomarker diagnosis prognosis prediction glioma because extracellular vesicles (EVs) carry molecular components from their parental cells.Methods: To detect EVs perform analysis serum EVs, we established optimized microbead-assisted method based on flow...
Abnormal activation of neddylation modification and dysregulated energy metabolism are frequently seen in many types cancer cells. Whether how affects cellular remains largely unknown. Here, we showed that MLN4924, a small-molecule inhibitor modification, induces mitochondrial fission-to-fusion conversion breast cells via inhibiting ubiquitylation degradation fusion-promoting protein mitofusin 1 (MFN1) by SCFβ-TrCP E3 ligase blocking the translocation fusion-inhibiting DRP1. Importantly,...
Alzheimer's disease (AD) is the most common form of dementia characterized by progressive cognitive decline. Current diagnosis AD based on symptoms, neuropsychological tests, and neuroimaging, usually evident years after pathological process. Early assessment at preclinical or prodromal stage in a great demand since treatment onset can hardly stop reverse progress. However, early challenging due to lack reliable noninvasive approaches. Here, an antibody‐mimetic self‐assembling peptoid...
Abstract Background Clear cell renal carcinoma (ccRCC) is a malignancy characterized by metabolic reprogramming. ABAT and ALDH6A1 are enzymes. In this study, we aim to investigate the associations of with ccRCC cells. Methods The gene expression levels in were analyzed from microarray datasets RNA sequencing data. Clinical information was Cancer Genome Atlas (TCGA) distributions clinical tissues screened reverse transcription-quantitative polymerase chain reaction (RT-QPCR)...
Our previous study demonstrated that the zinc (Zn) proteinate with moderate chelation strength (Zn-Prot M) enhanced Zn absorption in small intestine partially via increasing expression of some and amino acid transporters duodenum broilers. However, it remains unknown whether Zn-Prot M could also regulate related jejunum ileum broilers above enhancement absorption. The present was conducted to investigate effect on compared sulfate (ZnS). Zinc-deficient (13-d-old) were fed Zn-unsupplemented...
Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due the difficulty delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, enhanced bioavailability over conventional drugs, are garnering attention for spinal treatment. This review explores current...
A flexible microneedle array electrode chip for low-voltage electroporation with good tissue adaptation, efficient nucleic acid delivery, and minimum damage.
Glioblastoma is one of the most common primary tumor types central nervous system (CNS) with high malignance and lethality.Although many treatment options are currently available, therapy brain cancers remains challenging because blood-brain-barrier (BBB) which prevents chemotherapeutics into CNS.In this work, a poly(amidoamine) dendrimer-based carrier was fabricated modified angiopep-2 (Ang2) peptide that has been demonstrated to bind low density lipoprotein receptor-relative protein-1...
The nanomechanical properties of tumor-derived small extracellular vesicles (sEVs) are essential to cancer progression. Here, nanoindentation is utilized on atomic force microscopy (AFM) quantitatively investigate the human breast cell-derived sEVs at single vesicle level and explore their relationship with tumor malignancy size. It demonstrated that stiffness results from combined contribution bending modulus osmotic pressure sEVs. increase increasing decrease size decreases lower in...
8500 Background: Neoadjuvant immune checkpoint inhibitors (ICIs) plus chemotherapy have a promising efficacy in resectable non-small-cell lung cancer (NSCLC), yet the period of neoadjuvant immunochemotherapy is undetermined. This phase II study compared and safety two cycles with three sintilimab stage IB-IIIA NSCLC. Methods: randomized, open-label trial recruited patients aged 18 or older histologically confirmed, treatment-naïve, American Joint Committee on Cancer-defined IB-IIIA, Eligible...
Background The prevalence of metabolic associated fatty liver disease (MAFLD) presented a booming growth over recent years in the whole world. MAFLD was with higher risk end-stage disease, hepatocellular carcinoma and transplantation. Accumulating evidence indicated that gut microbiota were interrelated interacted each other. However, to knowledge authors, no bibliometric quantitative analysis has been carried out evaluate links between MAFLD. This study aimed use current publication trends...
Abstract Extracellular vesicles (EVs) are natural vehicles carrying and transferring bioactive molecules for intercellular communication play key roles in physiological pathological processes. EVs promising biomarkers disease diagnosis due to their rich biological information minimally invasive sampling. In this review, we summarize the current methods isolating from body fluids techniques analyzing EVs’ biomolecules including proteins, nucleic acids, lipids. The advantages, feasibility,...
Transforming growth factor-beta (TGF-beta) stimulates myofibroblast transdifferentiation, leading to type I collagen accumulation and fibrosis. We investigated the function of Src in TGF-beta-induced accumulation. In human mesangial cells, PTyr416 (activated Src) was 3.3-fold higher TGF-beta-treated cells than controls. activation by TGF-beta blocked rottlerin a dominant negative mutant protein kinase Cdelta (PKCdelta), showing that activates PKCdelta-based mechanism. Pharmacological...
A dual-functional drug delivery system based on the conjugation of PAMAM dendrimer with EBP-1 and TAT peptide was established for therapy triple-negative breast cancer.
Lung cancer continues to be one of the most dangerous tumors around world. It is an urgency explore molecular mechanism non-small cell lung (NSCLC) progression for developing novel therapeutic approaches. Circular RNA (circRNA) a type non-coding with stable closed loop structure. Abnormally expressed circRNAs have been found in many kinds including NSCLC.The expression circGFRA1 and miR-188-3p was detected NSCLC tissues by RT-qPCR it that highly miR-183-3p lowly tissues. In lines, we...