A5100434182- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Circular RNAs in diseases
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- RNA Research and Splicing
- Bladder and Urothelial Cancer Treatments
- RNA Interference and Gene Delivery
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
- Epigenetics and DNA Methylation
- Renal cell carcinoma treatment
- Proteins in Food Systems
- Prostate Cancer Treatment and Research
- Spectroscopy and Chemometric Analyses
- Computational Drug Discovery Methods
- Spectroscopy Techniques in Biomedical and Chemical Research
- RNA and protein synthesis mechanisms
- Fibroblast Growth Factor Research
- Inflammatory Biomarkers in Disease Prognosis
- Autonomous Vehicle Technology and Safety
- Connective tissue disorders research
- Fault Detection and Control Systems
Kunming Medical University
2022-2025
First Affiliated Hospital of Kunming Medical University
2022-2025
State Key Laboratory of Food Science and Technology
2025
Nanchang University
2025
Shanghai Jiao Tong University
2024-2025
First Affiliated Hospital of Guangzhou Medical University
2025
Guangzhou Medical University
2025
Guangdong Provincial People's Hospital
2022-2024
Southern Medical University
2018-2024
Lakehead University
2024
Background Immune checkpoint blockade (ICB) has been approved for the treatment of triple-negative breast cancer (TNBC), since it significantly improved progression-free survival (PFS). However, only about 10% TNBC patients could achieve complete response (CR) to ICB because low rate and potential adverse reactions ICB. Methods Open datasets from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) were downloaded perform an unsupervised clustering analysis identify immune subtype...
Bladder cancer (BLCA) is one of the most common cancers and ranks ninth among all cancers. Extracellular matrix (ECM) genes activate a number pathways that facilitate tumor development. This study aimed at providing models to predict BLCA survival recurrence by ECM genes.Expression data from samples in GSE32894, GSE13507, GSE31684, GSE32548, TCGA-BLCA cohorts were downloaded analyzed. The ECM-related obtained differentially expressed gene analysis, stage-associated random forest variable...
Background: Bone metastasis is a leading cause of the high mortality rate prostate cancer (PCa), but curative strategies remain lacking. Recent studies suggest long non-coding RNAs (lncRNAs) may be potential targets to develop drugs. However, PCa bone metastasis-specifically-related lncRNAs were rarely reported. This study aimed identify crucial and reveal their function mechanisms. Methods: GSE32269 GSE26964 microarray datasets, downloaded from Gene Expression Omnibus database, used analyze...
Background: MicroRNAs (miRNAs) play key roles in a variety of pathological processes by interacting with their specific target mRNAs for translation repression and may function as oncogenes (oncomiRs) or tumor suppressors (TSmiRs). Therefore, web server that could predict the regulation relations between miRNAs small molecules is expected to achieve implications identifying potential therapeutic targets anti-tumor drug development. Methods: Upon obtaining positive/known molecule-miRNA pairs...
Gastric cancer (GC) is one of the major global health problems, especially in Asia. Nowadays, long non-coding RNA (lncRNA) has gained significant attention current research climate such as carcinogenesis. This desires to explore mechanism Prader–Willi region non-protein coding 1 (PWRN1) on regulating GC process. Differentially expressed lncRNAs tissues were screened out through microarray analysis. The and protein expression level detected by quantitative real-time PCR (qRT-PCR) Western...
Urothelial bladder cancer (BLCA) is one of the most common internal malignancies worldwide with poor prognosis. This study aims to explore effective prognostic biomarkers and construct a risk score model for patients BLCA.Weighted gene co-expression network analysis (WGCNA) was used identifying module related pathological stage BLCA based on RNA-Seq data retrieved from The Cancer Genome Atlas database. Prognostic screened by Cox proportional hazard regression random forest were that can...
The development of portable, cost-effective, and highly sensitive biosensors for real-time biomarker detection is crucial advancing point-of-care testing (POCT) wearable health monitoring. Here, we present an integrated portable electrochemical sensor (ip-ECS) that combines gold nanoparticles (AuNPs) MXene-modified screen-printed electrodes (SPEs) with a custom-designed, low-power electronic system monitoring serum biomarkers. AuNPs MXene nanocomposite significantly enhances the performance...
Previous studies have reported that long noncoding RNAs (lncRNAs) acted as new players during tumorigenesis. Metallothionein also plays an important role in tumor progression. It is mainly considered to be involved the process of cell proliferation, oxidative stress, and multidrug resistance. However, potential involvement metallothionein-related lncRNAs colon cancer remains poorly understood. In our study, we found MT1M affected expression lncRNA STEAP3-AS1. STEAP3-AS1 located physical...
Preclinical models of tumors have the potential to become valuable tools for commercial drug research and development, 3D culture systems are gaining traction in this area, particularly prostate cancer (PCa) research. However, nearly all design screening assessments based on 2D experiments, suggesting limitations testing. To simulate natural response human cells drug, we detected half-maximal inhibitory concentration (IC50) changes 2D/3D LNCaP docetaxel, as well sensitivity different...
Basal and luminal subtypes of muscle-invasive bladder cancer (MIBC) have distinct molecular profiles heterogeneous clinical behaviors. The interactions between mRNAs lncRNAs, which might be regulated by miRNAs, crucial roles in many cancers. However, the miRNA-dependent crosstalk lncRNA mRNA specific MIBC still remains unclear. In this study, we first classified into two conservative using miRNA, expression data derived from Cancer Genome Atlas. Then investigated subtype-related biological...
Introduction: Prostate cancer (PCa) is dependent on coupled androgen-androgen receptor (AR) signaling for growth and progression. Significant efforts have been made in this research field, as hormonal therapies greatly improved the survival of patients with metastatic PCa (mPCa). The drug treatment agent JQ1, which potently abrogates bromodomain 4 (BRD4) localization to AR target loci therefore significantly impairs AR-mediated gene transcription, a potent therapeutic option advanced PCa. In...
Gastric cancer (GC), as a common gastrointestinal tumor, is an important cause of death from all around the world. Long non-coding RNAs (lncRNAs), novel class transcripts, have attracted great attention researchers. However, mechanisms clinical significance most lncRNAs in human are mainly undocumented. This research desires to explore significance, biological function, and mechanism Lnc_ASNR (apoptosis suppressing-non-coding RNA) GC. Cell proliferation, cell cycle, migration, invasion...
According to clinical study results, immune checkpoint blockade (ICB) treatment enhances the survival outcome of patients with clear cell renal carcinoma (ccRCC). Previous research has divided ccRCC into subtypes distinct ICB response rates. However, on association between lncRNAs and is lacking.Differentially expressed lncRNAs/mRNAs two major subgroups were calculated. A weighted gene co-expression network analysis (WGCNA) was conducted establish lncRNA-mRNA select key lncRNAs. Then,...
Tongue squamous cell carcinoma (TSCC) patients with high-grade tumors usually suffer from high occurrence and poor prognosis. The current study aimed at finding the biomarkers related to tumor grades proposing potential therapies by these biomarkers.The mRNA expression matrix of TSCC samples Cancer Genome Atlas (TCGA) database was analyzed identify hub proteins grades. patterns between adjacent control were validated in three independent data sets (i.e., GSE9844, GSE30784, GSE13601)....
Introduction: Hub genes related to the development of gastric cancer (GC) were identified based on bioinformatics methods. This study aimed identify GC hub genes, explore expression in and their correlation with prognosis, so as provide strategies for diagnosis targeted therapy. Methods: Two messenger RNA (mRNA) microarray datasets downloaded from GEO database. These data combined TCGA database obtain common DEGs between tissues normal tissues. GO KEGG pathway enrichment analysis was...