A5100355375- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- interferon and immune responses
- Ubiquitin and proteasome pathways
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA Research and Splicing
- Peptidase Inhibition and Analysis
- Hedgehog Signaling Pathway Studies
- Epigenetics and DNA Methylation
- Mycobacterium research and diagnosis
- Pulmonary Hypertension Research and Treatments
- Cytokine Signaling Pathways and Interactions
- Cancer-related gene regulation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Inflammasome and immune disorders
- Autophagy in Disease and Therapy
- Protein Kinase Regulation and GTPase Signaling
- Endoplasmic Reticulum Stress and Disease
- Cancer Research and Treatments
- NF-κB Signaling Pathways
- Glycosylation and Glycoproteins Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer Mechanisms and Therapy
Nanchang University
2014-2025
Second Affiliated Hospital of Zhejiang University
2025
Hebei Medical University
2014-2025
Fourth Hospital of Hebei Medical University
2015-2025
Ganzhou People's Hospital
2025
First Affiliated Hospital of Jiangxi Medical College
2024-2025
Huazhong University of Science and Technology
2021-2024
First Affiliated Hospital of Nanchang University
2016-2024
Wayne State University
2024
University of South China
2023
Mitochondria are high dynamic organelles with frequent fission and fusion. Here, we found hypoxia stimulated Drp1 expression, mitochondrial migration in metastatic MDA-MB‑231 cells, but not non-metastatic MCF-7 cells. Inhibition of Drp1-dependent by Mdivi-1 or silencing attenuated hypoxia-induced On the other hand, cisplatin induced significant apoptosis also efficiently prevented cisplatin-induced MMP decrease, ROS production Our data suggest that only regulates breast cancer facilitates...
// Jianjun Yu 1, * , Yan Liu 2, Zhaojian Gong 3, 4 Shanshan Zhang 3 Can Guo 2 Xiayu Li 5 Yanyan Tang Liting Yang Yi He Fang Wei Yumin Wang Qianjin Liao Wenling Xiaoling Yong 6 Guiyuan Xiong Zhaoyang Zeng 1 Department of Head and Neck Surgery, Hunan Cancer Hospital The Affiliated Xiangya School Medicine, Central South University, Changsha, Hunan, China Key Laboratory Carcinogenesis the Chinese Ministry Health, Research Institute, Invasion Education, Hospital, Stomatolog, Second Nonresolving...
Neutrophil extracellular traps (NETs) that are produced in the tumour microenvironment (TME) have been suggested to play an essential role dissemination of metastatic cancer under multiple infectious and inflammatory conditions. However, functions NETs promoting non-small cell lung (NSCLC) metastasis underlying mechanisms remain incompletely understood. Here, we found promoted NSCLC invasion migration by inducing epithelial mesenchymal transition (EMT). To explore how contribute metastasis,...
Dental caries is the most common human disease caused by oral biofilms despite widespread use of fluoride as primary anticaries agent. Recently, an FDA-approved iron oxide nanoparticle (ferumoxytol, Fer) has shown to kill and degrade caries-causing through catalytic activation hydrogen peroxide. However, Fer cannot interfere with enamel acid demineralization. Here, we show notable synergy when combined stannous (SnF
As a typical E3 ligase, TRIM65 (tripartite motif containing 65) is involved in the regulation of antiviral innate immunity and pathogenesis certain tumors. However, role renal cell carcinoma (RCC) underlying mechanism has not been determined yet. In this study, we identified as novel oncogene RCC, which enhanced tumor proliferation anchorage-independent growth abilities both vitro vivo. Moreover, found that TRIM65-regulated RCC mainly via direct interaction with BTG3 (BTG anti-proliferation...
Abstract Intestinal ischemia-reperfusion (II/R) injury is an urgent clinical disease with high incidence and mortality, impaired intestinal barrier function caused by excessive apoptosis of cells important cause its serious consequences. Tripartite motif-containing protein 65 (TRIM65) E3 ubiquitin ligase that recently reported to suppress the inflammatory response apoptosis. However, biological regulation TRIM65 in II/R are totally unknown. We found was significantly decreased...
Utilizing the oxidation/elimination tandem reaction of α-phenylseleno carbonyl moiety, a two-photon fluorescent probe for ratiometric visualization hypochlorous acid was developed. Its superior sensing performance and practical applications were well demonstrated.
Recent studies demonstrated that long non-coding RNAs (lncRNAs) deregulated in many cancer tissues including nasopharyngeal carcinoma (NPC) and had critical roles progression metastasis.In this study, we aimed to assess a lncRNA LINC01420 expression NPC explore its role pathogenesis.Our research revealed the level of were higher than epithelial (NPE) tissues.Moreover, patients with high showed poor overall survival.Knockdown inhibited cell migration invasion vitro.In summary, may play serve...
Apoptosis is a critical process in normal mammary gland development and the rapid clearance of apoptotic cells prevents tissue injury associated with release intracellular antigens from dying cells. Milk fat globule-EGF-factor 8 (Mfge8) milk glycoprotein that abundantly expressed epithelium has been shown to facilitate lymphocytes by splenic macrophages. We report mice disruption Mfge8 had until involution. However, abnormal remodeling was observed postlactation mutant mice. During early...
Abstract Objectives Micro RNA s (mi s) are endogenous small non‐coding that regulate proteins and mRNA for degradation or translational suppression. Up to now, the role of miR‐372 in renal cell carcinoma has remained unknown; this study, we have aimed reveal its functional importance tumour. Materials methods qRT ‐ PCR was performed measure expression levels lines tissues. CCK ‐8 an invasion assay were role. Luciferase assays, western blotting discover miR‐372′s target gene. Results We...
Esophageal carcinoma is characterized by a widely ranged incidence variation among the different geographic regions. Anyang county in Henan Province of North China with highest prevalence esophageal carcinoma. Human papillomavirus (HPV) infection has been linked to etiology cancer this area. In study, we investigated correlations polymorphisms at low molecular weight polypeptide ( LMP ) and transporters antigen processing TAP genes, risk DNA extracted from either tumor specimens or...
Minichromosome maintenance protein 2 (MCM2), which is a member of MCM family, has been found to be relevant marker for progression and prognosis in variety human cancers. Due lack effective therapeutic target lung squamous cell carcinoma (LUSC) patients, the aim our study was screen identify biomarkers are associated clinicopathological characteristics including LUSC patients.The expression status MCM2 cancer analyzed using publicly available Gene Expression Omnibus databases (GSE3268...
Abstract Endothelial activation by proinflammatory cytokines is closely associated to the pathogenesis of atherosclerosis and other vascular diseases; however, molecular mechanisms controlling endothelial are not fully understood. Here we identify TRIM14 as a new positive regulator via activating NF-κB signal pathway. highly expressed in human cells (ECs) markedly induced inflammatory stimuli such TNF-α, IL-1β, LPS. Overexpression significantly increased expression adhesion molecules VCAM-1,...
Abstract Although the adhesion molecules-mediated leukocyte adherence and infiltration into tissues is an important step of inflammation, post-translational regulation these proteins on endothelial cells poorly understood. Here, we report that TRIM65, ubiquitin E3 ligase tripartite protein family, selectively targets vascular cell molecule 1 (VCAM-1) promotes its ubiquitination degradation, by which it critically controls duration magnitude sepsis-induced pulmonary inflammation. TRIM65...
Long non-coding RNAs (lncRNAs) have been established as pivotal players in various cellular processes, encompassing the regulation of transcription, translation and post-translational modulation proteins, thereby influencing functions. Notably, lncRNAs exert a regulatory influence on diverse biological particularly context tumor development. Tumor-associated macrophages (TAMs) exhibit M2 phenotype, exerting significant impact crucial processes such initiation, angiogenesis, metastasis immune...
A lignan-rich diet is associated with a lower risk of human breast cancer. Enterolactone, an active polyphenol metabolites lignan, was reported to have antitumor effect. We investigated the mechanism for effect enterolactone against Cellular changes, and genes induced by enterolactone, were in MDA-MB-231 cells. Enterolactone showed antiproliferative effect, its IC50 261.9 ± 10.5 μM treatment period 48 hr. The mRNA levels related cell proliferation, Ki67, PCNA, FoxM1, reduced. accumulation...
Approximately 10% of all bone fractures do not heal, resulting in patient morbidity and healthcare costs. However, no pharmacological treatments are currently available to promote efficient healing. Inhibition Ca
This study aimed to explore the effect of long non-coding RNA (LncRNA) H19 on proliferation and invasion lung carcinoma cells A549, determine its molecular targets.A549 were with either LncRNA or shRNA, expression levels evaluated by quantitative real-time PCR (RT-PCR). We measured cell using CCK-8 assay, counting assays, colony formation assay in response shLncRNA H19-2. Cell migration assessed wound healing Transwell respectively. The mRNA protein E-cadherin, N-cadherin, vimentin...