A5003898324- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Nanoplatforms for cancer theranostics
- Adipose Tissue and Metabolism
- Circular RNAs in diseases
- Echinoderm biology and ecology
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- Animal Nutrition and Physiology
- Hedgehog Signaling Pathway Studies
- Molecular Biology Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Spinal Cord Injury Research
- Osteoarthritis Treatment and Mechanisms
- HIV Research and Treatment
- Extracellular vesicles in disease
- Cancer, Hypoxia, and Metabolism
- Drug Transport and Resistance Mechanisms
- Cancer therapeutics and mechanisms
- Stress and Burnout Research
- Workplace Health and Well-being
- Genomics and Chromatin Dynamics
- Cell death mechanisms and regulation
Sichuan University
2025
West China Second University Hospital of Sichuan University
2025
Binzhou University
2025
Binzhou Medical University
2025
Yancheng Third People's Hospital
2025
Harbin University
2025
Affiliated Hospital of Southwest Medical University
2017-2024
Xiangya Hospital Central South University
2023-2024
Central South University
2023-2024
Guangxi University
2023-2024
Intrahepatic cholangiocarcinoma (ICC) is the second most common liver malignancy. ICC typically features remarkable cellular heterogeneity and a dense stromal reaction. Therefore, comprehensive understanding of diversity interplay between malignant cells niche essential to elucidate mechanisms driving progression develop therapeutic approaches.Herein, we performed single-cell RNA sequencing (scRNA-seq) analysis on unselected viable from 8 human ICCs adjacent samples transcriptomic landscape...
Cervical squamous cell carcinoma (CESC) is a prototypical human cancer with well-characterized pathological stages of initiation and progression. However, high-resolution knowledge the transcriptional programs underlying each stage CESC lacking, important questions remain. We performed single-cell RNA sequencing 76,911 individual cells from 13 samples cervical tissues at various malignancy, illuminating tumorigenic trajectory epithelial revealing key factors involved in In addition, we found...
Abstract An organoiridium–albumin bioconjugate ( Ir1‐HSA ) was synthesized by reaction of a pendant maleimide ligand with human serum albumin. The phosphorescence enhanced significantly compared to parent complex Ir1 . long lifetime and high 1 O 2 quantum yield are highly favorable properties for photodynamic therapy. mainly accumulated in the nucleus living cancer cells showed remarkable photocytotoxicity against range cell lines tumor spheroids (light IC 50 ; 0.8–5 μ m , photo‐cytotoxicity...
Anatase TiO2 is considered as one of the promising anode materials for lithium ion batteries (LIBs) because its nontoxicity, safety, and excellent capacity retention. However, poor rate capability electrodes, caused by low electrical conductivity diffusion coefficient, strongly hinders practical application in high power LIBs. Herein, we report on fast storage performance hydrogenated anatase nanoparticles (H-TiO2) prepared a H2 plasma treatment. The scan-rate dependence cyclic voltammetry...
We present a second near-infrared (NIR-II) self-checking molecule, LET-1052, for acidic tumor microenvironment (TME) turn-on photothermal therapy (PTT), followed by viscosity based therapeutic efficacy evaluation itself in two independent channels, denoted as "self-checking" strategy. In TME, LET-1052 was protonated and turned on NIR-II absorption PTT under 1064 nm laser irradiation. Subsequently, PTT-induced cellular death increases intracellular viscosity, which inhibited the...
ABSTRACT Sepsis can cause myocardial injury, which is one of the leading causes death in critically ill patients. The underlying mechanisms associated with sepsis-induced injury (SIMI) include impaired cardiac contractility, excessive inflammation, oxidative stress, cardiomyocyte apoptosis, and so on. SIMI usually accompanied dynamic changes microRNAs (miRNAs) expression. And previous studies have shown that miR-214 plays a vital role protection subjected to stress. In this study, we aimed...
Competitive consumption of nutrients between rapidly proliferating cancer cells and T results in an immunosuppressive tumor microenvironment (TME) nutrient deprivation cells, which can cause low response rate resistance to immunotherapies. In this study, we proposed a dual-mechanism based partitioning nanoregulator (designated as DMNPN), simultaneously regulate the TME enhance cell availability. DMNPN consists charge-reversal biodegradable mesoporous silica, encapsulating glycolysis...
Abstract Human melanocytic nevi (moles) result from a brief period of clonal expansion melanocytes. As cellular defensive mechanism against oncogene-induced hyperplasia, nevus-resident melanocytes enter senescent state stable cell cycle arrest. Senescent can persist for months in mice and years humans with risk to escape the progress melanoma. The mechanisms providing prolonged survival remain poorly understood. Here, we show that culture express high level anti-apoptotic BCL-2 family member...
Abstract Osteoarthritis (OA) is a degenerative disease that significantly impairs quality of life. There pressing need for innovative OA therapies. While small extracellular vesicles (sEVs) show promising therapeutic effects against OA, their limited yield restricts clinical translation. Here, we devised novel production system sEVs enhances both and properties. By stimulating mesenchymal stem cells (MSCs) using electromagnetic field (EMF) combined with ultrasmall superparamagnetic iron...
Macropinocytosis is a transient endocytosis that internalizes extracellular fluid and particles into vacuoles. Recent studies suggest hyperstimulation of macropinocytosis can induce novel nonapoptotic cell death, methuosis. In this report, we describe the identification an ursolic acid derived small molecule (compound 17), which induces cancer death through macropinocytosis. 17 causes accumulation vacuoles from macropinosomes based on transmission electron microscopy, time-lapse labeling...
Abstract We present a second near‐infrared (NIR‐II) self‐checking molecule, LET‐1052, for acidic tumor microenvironment (TME) turn‐on photothermal therapy (PTT), followed by viscosity based therapeutic efficacy evaluation itself in two independent channels, denoted as “self‐checking” strategy. In TME, LET‐1052 was protonated and turned on NIR‐II absorption PTT under 1064 nm laser irradiation. Subsequently, PTT‐induced cellular death increases intracellular viscosity, which inhibited the...